Correction to: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer.

abstract：BACKGROUND:Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely u...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He A,Liu Y,Chen Z,Li J,Chen M,Liu L,Liao X,Lv Z,Zhan Y,Zhuang C,Lin J,Huang W,Mei H

更新日期：2016-08-11 00:00:00

abstract：:Doxorubicin (DOX) has a wide spectrum of antitumor activity with dose-related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result from the generation of oxygen-free radicals. The objective of the present study was to investigate the influence of the antioxidant, thymoquinone (TQ) on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： al-Shabanah OA,Badary OA,Nagi MN,al-Gharably NM,al-Rikabi AC,al-Bekairi AM

更新日期：1998-06-01 00:00:00

abstract：:The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequenci...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Grillone K,Riillo C,Scionti F,Rocca R,Tradigo G,Guzzi PH,Alcaro S,Di Martino MT,Tagliaferri P,Tassone P

更新日期：2020-06-20 00:00:00

abstract：:The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA seq...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Geng X,Li Q,Xu J,Tan Y,Xiao M,Song J,Liu F,Fang C,Wang H

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechanisms underlying the action of ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu L,Wu N,Wang Y,Zhang X,Xia B,Tang J,Cai J,Zhao Z,Liao Q,Wang J

更新日期：2019-02-28 00:00:00

abstract：BACKGROUND:Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating Mn...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao X,Liu L,Yuan Q,Li X,Cui Y,Ren K,Zou C,Chen A,Xu C,Qiu Y,Quan M,Zhang J,Cao J,Chen X

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at iden...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Meenakshisundaram R,Gragnoli C

更新日期：2009-03-28 00:00:00

abstract：BACKGROUND:Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kidera Y,Tsubaki M,Yamazoe Y,Shoji K,Nakamura H,Ogaki M,Satou T,Itoh T,Isozaki M,Kaneko J,Tanimori Y,Yanae M,Nishida S

更新日期：2010-09-16 00:00:00

abstract：BACKGROUND:Celastrol, a triterpene compound derived from the traditional Chinese medicine Tripterygium wilfordii, has been reported to possess potential antitumor activity towards various malignancies. However, the effect of celastrol on glioma cells and the underlying molecular mechanisms remain elusive. METHODS:Glio...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu X,Zhao P,Wang X,Wang L,Zhu Y,Song Y,Gao W

更新日期：2019-05-03 00:00:00

abstract：:Since the social and financial impact of AML therapy is becoming more and more relevant we analyzed the cost of induction therapy of two different regimens. The first one is part of the widely employed EORTC-GIMEMA AML-10 and consists often days of therapy. The second (FLANG) is a short (three day), Fludarabine, Ara-C...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Clavio M,Quintino S,Masoudi B,Carrara S,Cerri R,Pierri I,Canepa L,Miglino M,Muner P,Damasio E,Gobbi M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents against this disease is urgent. Salinomycin induces broad anti-cancer effects; however, its role in GBM and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qin LS,Jia PF,Zhang ZQ,Zhang SM

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu B,Wang Y,Yang XM,Xu BQ,Feng F,Wang B,Liang Q,Li Y,Zhou Y,Jiang JL,Chen ZN

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins and cell fusion. In this study,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu K,Zheng M,Zhao Q,Zhang K,Li Z,Fu F,Zhang H,Du J,Li Y,Zhang S

更新日期：2020-05-11 00:00:00

abstract：:Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Watanabe H,Ando Y,Uesaka T,Ishimura Y,Shiraki K,Lu H,Ohara M,Shoji S,Katoh O

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Immunocytochemistry and RT-PCR have been widely used for the detection of circulating tumor cells in patients with breast cancer but their specificity is limited. Our purpose is to utilize a convenient and specific technology to detect circulating tumor cells in breast cancer patients. METHODS:To determine ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Wang Y,Liu Y,Cheng M,Wu X,Wei H

更新日期：2009-04-28 00:00:00

abstract：PURPOSE:There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (131I-5-IPN) and evaluate its therapeutic...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Xu X,Yuan L,Gai Y,Liu Q,Yin L,Jiang Y,Wang Y,Zhang Y,Lan X

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Classical Kaposi's Sarcoma (cKS) is a rare vascular tumor, which develops in subjects infected with Human Herpesvirus-8 (HHV-8). Beside the host predisposing factors, viral genetic variants might possibly be related to disease development. The aim of this study was to identify HHV-8 variants in patients with...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cordiali-Fei P,Trento E,Giovanetti M,Lo Presti A,Latini A,Giuliani M,D'Agosto G,Bordignon V,Cella E,Farchi F,Ferraro C,Lesnoni La Parola I,Cota C,Sperduti I,Vento A,Cristaudo A,Ciccozzi M,Ensoli F

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction of apoptosis. However, the molecular mechanism of apoptosis induct...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yanae M,Tsubaki M,Satou T,Itoh T,Imano M,Yamazoe Y,Nishida S

更新日期：2011-08-10 00:00:00

abstract：BACKGROUND:Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Englinger B,Kallus S,Senkiv J,Heilos D,Gabler L,van Schoonhoven S,Terenzi A,Moser P,Pirker C,Timelthaler G,Jäger W,Kowol CR,Heffeter P,Grusch M,Berger W

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prosta...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li H,Ruan G,Li Z,Liu Z,Zheng X,Zheng H,Cheng G,Li B,Zhan M

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent. The IL6/STAT3 signaling pathway has been suggested as an attractive target for the discovery of novel cancer t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang L,Lin S,Kang Y,Xiang Y,Xu L,Li J,Dai X,Liang G,Huang X,Zhao C

更新日期：2019-01-23 00:00:00

abstract：BACKGROUND AND AIM:in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is still unclear. The purpose of this article is to investigate Antisense Oligonucleotide (ASO...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu C,Wu X,Luo C,Hu Z,Yin Z,He Y,Du H,Zhang W,Jiang Q,Lin Y

更新日期：2010-06-03 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has been identified to promote the growth of primary breast cancer, however, it can also antagonize sign...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu BW,Yu ZH,Chen AX,Chi JR,Ge J,Yu Y,Cao XC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:As the expression of human sperm protein 17 (Sp17) in normal tissue is limited and the function is obscure, its aberrant expression in malignant tumors makes it to be a candidated molecular marker for tumor imaging diagnosis and targeting therapy of the diseases.The aim of this research is to evaluate the ta...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li FQ,Zhang SX,An LX,Gu YQ

更新日期：2011-03-03 00:00:00

abstract：:Imatinib mesylate (IM), is a selective and competitive inhibitor of tyrosine kinases, including BCR-ABL, ABL, KIT, and the platelet-derived growth factor receptors (PDGF-R). It binds to the ATP-binding site of the target kinase and prevents the transfer of phosphate from ATP to the tyrosine residues of various substra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fiorentini G,Rossi S,Lanzanova G,Biancalani M,Palomba A,Bernardeschi P,Dentico P,De Giorgi U

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huebner H,Strick R,Wachter DL,Kehl S,Strissel PL,Schneider-Stock R,Hartner A,Rascher W,Horn LC,Beckmann MW,Ruebner M,Fahlbusch FB

更新日期：2017-11-23 00:00:00

abstract：:Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than tha...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Di X,Nishizaki T,Harada K,Kajiwara K,Nakayama H,Ito H

更新日期：1997-06-01 00:00:00

abstract：:Two-year protocols are commonly used for long-term assay of chemicals for carcinogenicity. However, in some cases, if animals have been exposed to tested agent from the young age and sacrificed at the age of 2, an underestimation of the carcinogenic potential of non-genotoxic agents and tumor promoters is possible. Da...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Anisimov VN

更新日期：1998-09-01 00:00:00