Turcot syndrome: case report and nosological aspects.

abstract：:PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with positive PD-L1 expression. However, PD-1/PD-L1 checkpoint blockades have not achie...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang X,Guo G,Guan H,Yu Y,Lu J,Yu J

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin J,Lin W,Ye Y,Wang L,Chen X,Zang S,Huang A

更新日期：2017-09-29 00:00:00

abstract：:We report a case of a 72-year-old male, with a known history of non-Hodgkin lymphoma of the left tonsil for two years, histologically proved and successfully treated by radical surgical excision in combination with external radiotherapy. He presented with diffuse bone pain the last month, especially at the lower left ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pistevou-Gombaki K,Eleftheriadis N,Sofroniadis I,Makris P,Kouloulias V

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins and cell fusion. In this study,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu K,Zheng M,Zhao Q,Zhang K,Li Z,Fu F,Zhang H,Du J,Li Y,Zhang S

更新日期：2020-05-11 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogenous group of hematological clonal malignancies. Patients belonging to the refractory anemia (RA) subtype are usually treated with recombinant human erythropoietin (EPO). Not all patients respond to EPO administration and they are strictly dependent on supportive therapy w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tsiara SN,Chaidos A,Gouva M,Christou L,Panteli K,Kapsali E,Bourantas KL

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Lang C,Wu Z,Dai Y,He S,Guo W,Huang S,Du H,Ren D,Peng X

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theorie...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Signorile PG,Baldi F,Bussani R,D'Armiento M,De Falco M,Baldi A

更新日期：2009-04-09 00:00:00

abstract：:For a long time now we have been putting forwards the hypothesis that, when two cells belonging to different tissues of the same organism fuse, the nucleous/nuclei of the resulting "fused" cell could lay into a cytoplasm possibly containing factors influencing the activation or deactivation of genes able to interfere ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Sebastiani M,Soldati V

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The sustained growth of tumors necessitates neovascularization. As one of the potent endogenous vascular inhibitors, endostatin has been widely used in antiangiogenesis therapy for tumor. Cisplatin is normally administered in chemotherapy for lung cancer but accompanied with serious side effects. In the curr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bai RZ,Wu Y,Liu Q,Xie K,Wei YQ,Wang YS,Liu K,Luo Y,Su JM,Hu B,Liu JY,Li Q,Niu T,Zhao ZW,Yang L

更新日期：2009-03-05 00:00:00

abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Parallel to complex alteration in molecular and cellular events, enrichment of cancer stem cells (CSC) contributes significantly in deliberation and maintenance of cisplatin resistance. Cisplatin mediated CSC enrichment is well established in various cancers, yet the underlying mechanism is largely unknown. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Thakur B,Ray P

更新日期：2017-11-23 00:00:00

abstract：INTRODUCTION:Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of several molecular markers in breast cancer has been of considerable interest during recent years suc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Mao XY,Fan CF,Zheng HC,Wei J,Yao F,Jin F

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:Emerging evidence has shown long noncoding RNAs (lncRNAs) exert important roles in colorectal cancer (CRC) tumorigenesis. However, most lncRNAs involved in this process remain undefined and the underlying molecular mechanisms mediated by lncRNAs are largely unknown. METHODS:An unbiased screening was used to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yu J,Han Z,Sun Z,Wang Y,Zheng M,Song C

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Colon cancer is the second leading cancer worldwide. Recurrent disease and chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. ATP-citrate lyase (ACLY), the first-step rate-controlling enzyme in lipid synthesis, is elevated in colon cancer. However, it remains unclear abou...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wen J,Min X,Shen M,Hua Q,Han Y,Zhao L,Liu L,Huang G,Liu J,Zhao X

更新日期：2019-09-12 00:00:00

abstract：BACKGROUND:Immunocytochemistry and RT-PCR have been widely used for the detection of circulating tumor cells in patients with breast cancer but their specificity is limited. Our purpose is to utilize a convenient and specific technology to detect circulating tumor cells in breast cancer patients. METHODS:To determine ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Wang Y,Liu Y,Cheng M,Wu X,Wei H

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a major component of TJs. However, the clinical significance and its regulation of kidney tumorigenesis...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Y,Gong Y,Ning X,Peng D,Liu L,He S,Gong K,Zhang C,Li X,Zhou L

更新日期：2018-11-14 00:00:00

abstract：:RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two catalytic subunits which were encoded by MAT2A and MAT2beta respectively. During tumorigeness of hepatocelluar car...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang Q,Liu QY,Liu ZS,Qian Q,Sun Q,Pan DY

更新日期：2008-11-21 00:00:00

abstract：:Tumours involving the scrotum are rare and primary malignant melanoma is among the rarest of these lesions. Between 1949 and 1996 only 7 cases have been reported. We present two cases of scrotal melanoma. The current recommendations and management strategies are discussed on the basis of a review of the literature. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Tandoğdu R,Ardjçoğlu A

更新日期：1998-03-01 00:00:00

abstract：:A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Przybylowska K,Zielinska J,Zadrozny M,Krawczyk T,Kulig A,Wozniak P,Rykala J,Kolacinska A,Morawiec Z,Drzewoski J,Blasiak J

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components. The specific degradation of nuclear components by the autophagy pathway is called nucleophagy. Most studies have focused on autophagic turnover ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Y,Jiang X,Zhang Y,Gao Z,Liu Y,Hu J,Hu X,Li L,Shi J,Gao N

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS:The changes of macrophage phenotypes after P...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fan P,Zhao J,Meng Z,Wu H,Wang B,Wu H,Jin X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing endogenous RNA (ceRNA) mechanisms. In this study, we exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qiao K,Ning S,Wan L,Wu H,Wang Q,Zhang X,Xu S,Pang D

更新日期：2019-10-17 00:00:00

abstract：:Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pain A,Samanta S,Dutta S,Saxena AK,Shanmugavel M,Kampasi H,Qazi GN,Sanyal U

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. METHODS:Apolipoprotein (ApoE) knock-out mice was used to analyze the intraperitoneal EC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) remains to be elucidated. METHODS:In vitro functional role of HOXD9 and RURY3 in GC cells was determin...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Dai W,Li J,Xiang L,Wu X,Tang W,Chen Y,Yang Q,Liu M,Xiao Y,Zhang W,Lin J,Wang J,Liu G,Sun Y,Jiang P,Li G,Li A,Liu S,Chen Y,Wang J

更新日期：2019-09-23 00:00:00

abstract：:This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2002-03-01 00:00:00

abstract：:Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this disease, adjuvant chemotherapy and radiotherapy are also very important in clinical practice. However, the notorious refractory lack of responses to radiochemotherapy greatly limits the applica...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu X,Liu W,Cao Q,Chen C,Chen Z,Xu Z,Li W,Liu F,Yao X

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Several targeted immunotherapies have recently showed significant advances in treatment of non-small cell lung cancer (NSCLC), including antibodies and inhibitors targeting programmed death-1 (PD-1) and its ligand (PD-L1). METHODS:Tumor tissue samples were prospectively collected from 183 patients with NSCL...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen Y,Liu Q,Chen Z,Wang Y,Yang W,Hu Y,Han W,Zeng H,Ma H,Dai J,Zhang H

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS:We performed a transcriptome-wide screen to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi H,Li H,Yuan R,Guan W,Zhang X,Zhang S,Zhang W,Tong F,Li L,Song Z,Wang C,Yang S,Wang H

更新日期：2018-08-07 00:00:00