Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.

abstract：BACKGROUND:Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofib...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Umezu H,Endo N

更新日期：2009-03-31 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has been identified to promote the growth of primary breast cancer, however, it can also antagonize sign...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu BW,Yu ZH,Chen AX,Chi JR,Ge J,Yu Y,Cao XC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Ewing's sarcoma is an aggressive bone and soft tissue tumor with a high incidence in children and adolescents. Due to its high malignancy and poor prognosis, identification of novel biomarkers for intervention therapies is necessary to improve outcome. The EWS/FLI1 fusion gene is a characteristic of Ewing's ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ren C,Ren T,Yang K,Wang S,Bao X,Zhang F,Guo W

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused with HBx and upstream 56 amino acid, in HCC. In current study, the molecular functions of HBwx in H...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Liu H,Yi R,Yan T,He Y,Zhao Y,Liu J

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. METHODS:Use public database to screen the potential lncRNA crucial for metastasi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Huang W,Yuan Y,Li J,Wu J,Yu J,He Y,Wei Z,Zhang C

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cancer and ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang H,Li S,Yang X,Qiao B,Zhang Z,Xu Y

更新日期：2016-04-01 00:00:00

abstract：:Primary lymphoma of the breast is a rare disease that has been estimated to represent from 0.05% to 0.53% of all malignant breast tumors and approximately 2.2% of all extranodal lymphomas. The aim of this study is to review all cases of primary lymphoma of the breast at the Institute of Oncology and Radiology of Serbi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babovic N,Jelic S,Jovanovic V

更新日期：2000-06-01 00:00:00

abstract：:p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the hum...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Egilmez R,Elagöz S,Kanik EA

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer types, while its regulation in HCC is largely unknown. METHODS:To figure out the specific role of lncRN...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang YG,Wang T,Shi M,Zhai B

更新日期：2019-04-10 00:00:00

abstract：BACKGROUND:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is located at chromosome 16q22.1, a locus that harbours a number of tumour suppressor genes. It has been defined as a regulator of ce...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li T,Cheng Y,Wang P,Wang W,Hu F,Mo X,Lv H,Xu T,Han W

更新日期：2015-10-16 00:00:00

abstract：BACKGROUND:Parallel to complex alteration in molecular and cellular events, enrichment of cancer stem cells (CSC) contributes significantly in deliberation and maintenance of cisplatin resistance. Cisplatin mediated CSC enrichment is well established in various cancers, yet the underlying mechanism is largely unknown. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Thakur B,Ray P

更新日期：2017-11-23 00:00:00

abstract：:Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao KM,Chen XC,Zhang JX,Wang Y,Yan W,You YP

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kidera Y,Tsubaki M,Yamazoe Y,Shoji K,Nakamura H,Ogaki M,Satou T,Itoh T,Isozaki M,Kaneko J,Tanimori Y,Yanae M,Nishida S

更新日期：2010-09-16 00:00:00

abstract：:The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results were inconclusive and controversial. Our aim of this study was to evaluate this association by literature base...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Xie Y,Xian L

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

更新日期：2017-01-05 00:00:00

abstract：:Here we report the case of a patient with a soft tissue mass of the neck. For more than 10 years it was thought to be a branchial cyst and was later diagnosed to be a cystic lymph node metastasis from an occult thyroid carcinoma. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Appetecchia M,Meçule A,Sciarretta F

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Infection with the hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) has been shown to play an important role in the development of many types of human cancers. The role o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qin X,Li C,Guo T,Chen J,Wang HT,Wang YT,Xiao YS,Li J,Liu P,Liu ZS,Liu QY

更新日期：2017-10-19 00:00:00

abstract：:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kruger S,Ilmer M,Kobold S,Cadilha BL,Endres S,Ormanns S,Schuebbe G,Renz BW,D'Haese JG,Schloesser H,Heinemann V,Subklewe M,Boeck S,Werner J,von Bergwelt-Baildon M

更新日期：2019-06-19 00:00:00

abstract：:The Editor-in-Chief has retracted this article [1] due to concerns about the figures. In Figure 3C, the images from the colony formation assays of all cell lines, excluding the control for the HCCLM9 cell line, contain identical patterns of colonies; this suggests that despite the fact they are supposed to be observat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang Y,Qin X,Guo T,Liu P,Wu P,Liu Z

更新日期：2019-05-23 00:00:00

abstract：:Escherichia coli cytosine deaminase (CD), which is a prokaryotic enzyme, converts nontoxic prodrug 5-fluorocytosine (5-FC) into the toxic chemotherapeutic agent 5-fluorouracil (5-FU). To investigate an enzyme/prodrug gene therapy for colorectal cancer, using adenoviral gene transfer of the E. coli CD gene associated w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Koyama F,Sawada H,Fujii H,Hirao T,Ueno M,Hamada H,Nakano H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huebner H,Strick R,Wachter DL,Kehl S,Strissel PL,Schneider-Stock R,Hartner A,Rascher W,Horn LC,Beckmann MW,Ruebner M,Fahlbusch FB

更新日期：2017-11-23 00:00:00

abstract：BACKGROUND:Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS:We performed a transcriptome-wide screen to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi H,Li H,Yuan R,Guan W,Zhang X,Zhang S,Zhang W,Tong F,Li L,Song Z,Wang C,Yang S,Wang H

更新日期：2018-08-07 00:00:00

abstract：:Tumor ablation by radiofrequency (RFA) is an appealing therapeutical strategy for the treatment of liver tumors (hepatocarcinoma and metastatic lesions) to be used as valid alternative to the surgical resection that often is appropriate and feasible in only a minority of patients. RFA induces the localised and control...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rughetti A,Rahimi H,Rossi P,Frati L,Nuti M,Gaspari A,Danza FM,Ercoli L

更新日期：2003-12-01 00:00:00

abstract：:In the original publication of this article [1], the authors reported the order of the authors was incorrect and needs to be revised. The original article has been updated to rectify this error. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Xie B,Tang H,Meng W,Jia C,Zhang X,Zhang Y,Zhang J,Li H,Fu B

更新日期：2019-08-02 00:00:00

abstract：BACKGROUD:Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS:We performed circRNA microarrays to identify circRNAs that are aberrantly exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He R,Liu P,Xie X,Zhou Y,Liao Q,Xiong W,Li X,Li G,Zeng Z,Tang H

更新日期：2017-10-16 00:00:00

abstract：:Our previous studies have demonstrated the significant enzymatic activity of glycogen phosphorylase (GP) in the gastric carcinoma and proliferating cells of particular intestinal metaplasia (IM). This paper reviewed the identification of the GP isoform in the gastrointestinal carcinoma, and the investigation on the ro...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shimada S,Tashima S,Yamaguchi K,Matsuzaki H,Ogawa M

更新日期：1999-03-01 00:00:00

abstract：:The effect of malignant tumor growth on host's megakaryocytopoiesis and platelet production was studied in mice bearing transplantable Dalton's lymphoma. Tumor growth was paralleled by thrombocytosis, neutrophilia, and anemia. Platelet 51Cr half-life was normal but incorporation of 75Selenomethionine into circulating ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ray MR

更新日期：2000-12-01 00:00:00

abstract：:The aim of this work is the in vitro study of the late effects of single proton irradiation on HTB63 human melanoma cell growth, cell cycle and cell death. The experimental conditions were focused on analyzing the effects of irradiation on the periphery of tumour that can be, in clinical practice, close to critical or...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ristic-Fira A,Nikolic D,Petrovic I,Ruzdijic S,Raffaele L,Sabini MG,Cirrone GA,Cuttone G,Farruggia G,Masotti L,Kanazir DT

更新日期：2001-03-01 00:00:00

abstract：:In papillary thyroid carcinoma lymphnode metastases at presentation do not seem to adversely affect survival, but do increase the risk of loco-regional tumor recurrence. The value of systematic versus selective lymphadenectomy is far less standardized, whereas the role of postoperative radioiodine in preventing either...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ducci M,Appetecchia M,Marzetti M

更新日期：1997-09-01 00:00:00