ACLY facilitates colon cancer cell metastasis by CTNNB1.

abstract：:This study was undertaken in order to verify if peri-operative serum lactate level changes, resulting from manipulation of the splanchnic circulation during pancreatectomy, reflected clinical outcome in twenty patients (9 males-11 females age 33 to 76) operated for pancreatic cancer. Lactate levels were evaluated at t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gruttadauria S,Marino IR,Vitale CH,Mandala L,Scott VL,Doria C

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in diagnosis and treatment, the p...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhao Y,Zhu J,Shi B,Wang X,Lu Q,Li C,Chen H

更新日期：2019-07-11 00:00:00

abstract：:Renal cell carcinoma, in a high percentage of patients, metastasizes early, sometimes mimicking other lesions. We present a case of an asymptomatic papillary renal cell carcinoma that presented neck metastases as the initial manifestation. The laterocervical and supraclavicular masses were considered consistent with n...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Giuliani A,Caporale A,Borghese M,Galati G,Di Bari M,Demoro M

更新日期：1999-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan H,Li H,Li P,Li X,Lin J,Zhu L,Silva MA,Wang X,Wang P,Zhang Z

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously reported that cells expressing the K1 protein of human herpesvirus 8 (HHV-8) resist death through th...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Daniluk U,Kerros C,Tao RH,Wise JF,Ao X,Berkova Z,Samaniego F

更新日期：2012-08-28 00:00:00

abstract：:This retrospective study analyzed specifically the predicting factors for radioresponse and survival in 74 supratentorial astrocytoma patients. As a result of this study, cytoreduction in terms of ODs to T1 or T0 stage level or pre-RT T1 tumor stage along with radioresponse has a positive impact on long-term survival....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erkurt E,Tunali C,Erkişi M,Boyer B,Burgurt R

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma. PATIENTS AND METHODS:60 HILPs (G-A) were performed with mild HT plus L-PAM (10 mg/lt) +/- D-actimomycin; 74 HILP...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pace M,Gattai R,Matteini M,Mascitelli EM,Bechi P

更新日期：2008-11-12 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit anti-cancer effects....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zong L,Chen K,Jiang Z,Chen X,Sun L,Ma J,Zhou C,Xu Q,Duan W,Han L,Lei J,Li X,Ma Q,Wang Z

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Yu X,Zhang Z,Pang L,Xu J,Jiang J,Liang W,Chai Y,Hou J,Li F

更新日期：2017-12-13 00:00:00

abstract：:Tumor cells exhibit phenotypic and genotypic differences in comparison to normal cells. These differences can be used to identify proteins important for tumor growth and, therefore, potentially used in the diagnosis and follow-up of patients. The objective of this work was to investigate the electrophoretic pattern of...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Trejo-Becerril C,Pérez-Cárdenas E,Taja-Chayeb L,Zeichner-Gancz I,Delgado-Chávez R,Solorza-Luna G,Dueñas-González A

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:The sustained growth of tumors necessitates neovascularization. As one of the potent endogenous vascular inhibitors, endostatin has been widely used in antiangiogenesis therapy for tumor. Cisplatin is normally administered in chemotherapy for lung cancer but accompanied with serious side effects. In the curr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bai RZ,Wu Y,Liu Q,Xie K,Wei YQ,Wang YS,Liu K,Luo Y,Su JM,Hu B,Liu JY,Li Q,Niu T,Zhao ZW,Yang L

更新日期：2009-03-05 00:00:00

abstract：BACKGROUND:The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosstalk between two pathways is not completely understood. METHODS:The expression of STAT1 protein was ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tian X,Guan W,Zhang L,Sun W,Zhou D,Lin Q,Ren W,Nadeem L,Xu G

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

更新日期：2020-12-07 00:00:00

abstract：:Neoplastic transformation of heterotopic cervical salivary gland tissue is extremely rare. The Authors describe a case of pleomorphic adenoma arising in this tissue, on the right side of the neck in a 40-year old man. The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histo...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Baldi A,Persichetti P,Di Marino MP,Nicoletti G,Baldi F

更新日期：2003-12-01 00:00:00

abstract：:We measured the serum level of soluble Fas (sFas) antigen in gastric MALT (mucosa-associated lymphoid tissue) lymphoma patients to investigate immune response of B lymphoma cells in gastric MALT lymphoma. The serum sFas antigen levels in 21 patients with Helicobacter pylori (HP)-positive MALT lymphoma were 4.51+/-0.25...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Doi T,Nishikawa Y,Endo H,Hosokawa Y,Tanimizu M,Hyodo I

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10-15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development. METHODS:We examined...

journal_title：Journal of experimental & clinical cancer research : CR

authors： D'Angelo V,Iannotta A,Ramaglia M,Lombardi A,Zarone MR,Desiderio V,Affinita MC,Pecoraro G,Di Martino M,Indolfi P,Casale F,Caraglia M

更新日期：2015-08-14 00:00:00

abstract：BACKGROUND:Peroxiredoxins (Prxs) are a novel group of peroxidases containing high antioxidant efficiency. The mammalian Prx family has six distinct members (Prx I-VI) in various subcellular locations, including peroxisomes and mitochondria, places where oxidative stress is most evident. The function of Prx I in particu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cha MK,Suh KH,Kim IH

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk and disease outcome. We used a population-based series of esophageal squamous cell carcinoma (ESCC) ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang R,Wang R,Zhang F,Wu C,Fan H,Li Y,Wang C,Guo Z

更新日期：2010-11-26 00:00:00

abstract：PURPOSE:The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. METHODS:Systematic c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin Y,Wang C,Zhong Y,Huang X,Peng L,Shan G,Wang K,Sun Q

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Lang C,Wu Z,Dai Y,He S,Guo W,Huang S,Du H,Ren D,Peng X

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine 3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly or moderately emetogenic chemotherapy (HEC or MEC). The second goal wa...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tan L,Liu J,Liu X,Chen J,Yan Z,Yang H,Zhang D

更新日期：2009-09-23 00:00:00

abstract：BACKGROUND:Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin (CLU), an antiapoptotic molecule, could be a potential predictor molecule for ovarian cancer and wh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hassan MK,Watari H,Han Y,Mitamura T,Hosaka M,Wang L,Tanaka S,Sakuragi N

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8 in acute myeloid leukemia (AML) and consider the potential of EPS8 as an anti-AML target. Nuclear l...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen Y,Xie X,Wu A,Wang L,Hu Y,Zhang H,Li Y

更新日期：2018-01-22 00:00:00

abstract：:Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pain A,Samanta S,Dutta S,Saxena AK,Shanmugavel M,Kampasi H,Qazi GN,Sanyal U

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Multi-drug resistance and predisposition to metastasize are major clinical problems in cancer treatment. Malignant primary brain tumor and pancreatic cancer are two well-known examples of malignant tumors resistant to conventional therapies where aberrant EGFR-mediated and NF-κB signal transduction pathways ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Guerra B,Fischer M,Schaefer S,Issinger OG

更新日期：2015-10-20 00:00:00

abstract：:Horseshoe kidney is a congenital anomaly of the upper urinary system frequently associated with atypical vascularization, mostly asymptomatic, usually undetected until the onset of infectious, obstructive or neoplastic complications. Although intravenous pyelography and US are useful tools, the role of CT is of vital ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maccioni F,Stasolla A,D'Aprile MR,Binda B,Izzo L,Marini M

更新日期：2002-12-01 00:00:00

abstract：:The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fracasso P,Caviglia R,Grassi A,Lapenta R,Stigliano V,Franco D,Casale V

更新日期：1997-12-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical tri...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan Y,Chen X,Wang X,Zhao Z,Hu W,Zeng S,Wei J,Yang X,Qian L,Zhou S,Sun L,Gong Z,Xu Z

更新日期：2019-04-23 00:00:00