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Molecular genetics of prostate cancer: clinical translational opportunities.

Abstract：

:Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and treatment. To date, however, no molecular studies have yet yielded consistent information that is ready to be incorporated into clinical practice. We reviewed the current literature on the molecular biology of prostate cancer and analyzed different potential tumor markers according to the classical concepts of oncogenes, suppressor genes, and the more modern concepts of genes involved in detoxification or inflammatory pathways of cancer progression. This review aims to identify trends in PC research and suggests potential clinical applications for diagnosis, prognosis, prevention and treatment.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Vecchione A,Gottardo F,Gomella LG,Wildemore B,Fassan Ms,Bragantini E,Pagano F,Baffa R

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

25-37

issue

1

eissn

0392-9078

issn

1756-9966

journal_volume

26

pub_type

杂志文章,评审

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