Abstract：
:Radionuclide therapy with bone seeking radiopharmaceuticals is one of the oldest interventions in nuclear medicine and has been now in use for many years as an effective method of palliating painful bone metastases. Clinical indications have slowly but progressively increased starting from end-stage prostate cancer with diffuse painful bone metastases to earlier stages of several cancers with only microinvolvement of the skeleton. Several newer bone seeking agents for therapeutic applications have been developed during the last 10 years. A large body of specific literature is now available, but only a few well designed clinical trials can be selected to obtain evidence-based guidelines. This study summarizes the therapeutic effects of the three commercially available radiopharmaceuticals, the current indication for their use as supported by the most rigorous literature studies and the original contributions of the "Regina Elena" ten-year experience. Innovative strategies and future research questions are also breafly addressed.
journal_name
J Exp Clin Cancer Resjournal_title
Journal of experimental & clinical cancer research : CRauthors
Maini CL,Sciuto R,Romano L,Bergomi Ssubject
Has Abstractpub_date
2003-12-01 00:00:00pages
71-4issue
4 Suppleissn
0392-9078issn
1756-9966journal_volume
22pub_type
杂志文章,评审abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:We measured the serum level of soluble Fas (sFas) antigen in gastric MALT (mucosa-associated lymphoid tissue) lymphoma patients to investigate immune response of B lymphoma cells in gastric MALT lymphoma. The serum sFas antigen levels in 21 patients with Helicobacter pylori (HP)-positive MALT lymphoma were 4.51+/-0.25...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead to tumor sensitization to chemical and physical agents. The aim of this...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-29-46
更新日期：2010-05-12 00:00:00
abstract：:Human mammaglobin (hMAM) has recently been recognized as a breast associated glycoprotein. Although the biological role of hMAM is unknown, it has been previously reported that hMAM gene expression is a marker of low biological and clinical aggressiveness of breast cancer (BC). In this study, 148 cases of BC tissues w...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Accumulating evidence suggests that radiation treatment causes an adaptive response of lung adenocarcinoma (LUAD), which in turn attenuates the lethal effect of the irradiation. Previous microarray assays manifested the change of gene expression profile after irradiation. Bioinformatics analysis of the significantly c...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01772-y
更新日期：2020-11-23 00:00:00
abstract：BACKGROUND:In response to diverse genotoxic stimuli p53 is activated as transcription factor to exert its tumor-suppressor function. P53 activation requires protein stabilization, nuclear localization and posttranslational modifications in key residues that may influence p53 selection of target genes. Among them, serin...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-014-0079-4
更新日期：2014-09-27 00:00:00
abstract：:Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor progression, metastatization and resistance to therapy. New immunotherapeutic approaches aim at restorin...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-020-01586-y
更新日期：2020-05-18 00:00:00
abstract：BACKGROUND:In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in promoting development of HCC. Evidence is accumulating that members of the chemokine receptor family a...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-29-31
更新日期：2010-04-11 00:00:00
abstract：BACKGROUND:Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously reported that cells expressing the K1 protein of human herpesvirus 8 (HHV-8) resist death through th...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-31-69
更新日期：2012-08-28 00:00:00
abstract：BACKGROUND:Aberrant expression of Wiskott-Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. METHODS:Human pancreatic cancer sampl...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0848-6
更新日期：2018-07-24 00:00:00
abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-017-0658-2
更新日期：2017-12-13 00:00:00
abstract：:A 41-year-old white homosexual man presented with epigastric pain and jaundice. Physical examination showed enlargement of bilateral axillar and left inguinal lymph node, while ERCP and a CT scan suggested interruption of bile flow in the intrapancreatic tract of the common bile duct. An endoprosthesis was positioned ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theorie...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/1756-9966-28-49
更新日期：2009-04-09 00:00:00
abstract：:Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:This study was conducted to establish a feasible intraperitoneal xenograft model in nude mice which mimicked the dynamic progression of human ovarian cancer and to explore its potential for preclinical trials. A human ovarian tumor line SKOV3 was originally injected s.c. to develop tumors; then the tumors were harvest...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) is one of the frequently occurred malignancies in the world. To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. In the present study, we aimed to corroborate the oncogenic effect of miR-96 on CRC and to identify the spe...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01731-7
更新日期：2020-11-12 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the molecular mechanisms. METHODS:The cytotoxicity of a Gli1/2 inhibitor, GANT61 was examined both alone an...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0463-3
更新日期：2016-11-28 00:00:00
abstract：BACKGROUND:Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biological function in gallbladder cancer (GBC) remain largely unknown. METHODS:PHB and p-ERK protein ex...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-016-0346-7
更新日期：2016-04-16 00:00:00
abstract：:The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submit...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and progression of tumors. However, the exact role and underlying mechanism of ETV6 in HCC remain uncle...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-020-01559-1
更新日期：2020-04-23 00:00:00
abstract：BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：10.1186/s13046-019-1089-z
更新日期：2019-02-22 00:00:00
abstract：BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-1017-7
更新日期：2019-01-08 00:00:00
abstract：:Naphthalmustine, 2-[2-[bis-(2-chloroethyl)amino]ethyl]-1H-benz[de]isoquinoline-1,3-dione (Compound 1) has been synthesized as a rationally designed new anticancer agent from N-(2-bromoethyl)naphthalimide. Its chemical alkylating activity exceeded that of nor-HN2 used as standard compound for comparison. Its antitumour...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：UNLABELLED:In order to evaluate the influence of time intervals between tumor cell injection and radiotherapy on tumor control and regrowth after surgery, we performed two kinds of experiments on C3D2F1 mice bearing a mammary carcinoma inoculated in the foot or leg. 1st experiment: tumor in foot. END POINT:Tumor Contr...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extra...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-015-0226-6
更新日期：2015-10-06 00:00:00
abstract：:This retrospective study analyzed specifically the predicting factors for radioresponse and survival in 74 supratentorial astrocytoma patients. As a result of this study, cytoreduction in terms of ODs to T1 or T0 stage level or pre-RT T1 tumor stage along with radioresponse has a positive impact on long-term survival....
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Seventeen adult urologic sarcomas treated at the Oncology Hospital of Ankara in the last ten-year period are described. There were six cases of paratesticular rhabdomyosarcoma (RMS), four cases of liposarcoma (LS), three cases of leiomyosarcoma (LMS); two cases of Kaposi sarcoma limited to glans penis, and only one pr...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章,评审
doi：
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0701-y
更新日期：2018-02-26 00:00:00
abstract：:Preclinical research and ongoing clinical trials are validating epidermal growth factor receptor (EGFR) as a suitable molecular target in cancer therapy. Here we report the case of a 39-year-old non-smoking man with heavily pretreated stage IV bronchioloalveolar NSCLC who was treated with gefitinib ('Iressa', ZD1839) ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Dysregulation of transforming growth factor β (TGF-β) signaling and hypoxic microenvironment have respectively been reported to be involved in disease progression in malignancies of prostate. Emerging evidence indicates that downregulation of TGFBR2, a pivotal regulator of TGF-β signaling, may contribute to ...
journal_title：Journal of experimental & clinical cancer research : CR
pub_type： 杂志文章
doi：10.1186/s13046-018-0764-9
更新日期：2018-04-27 00:00:00
