Correlations between nuclear/cytoplasmic area ratio and classification of cervical smears.

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast ca...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tao S,Chen Q,Lin C,Dong H

更新日期：2020-09-17 00:00:00

abstract：:Occult carcinoma cells in peripheral blood of breast cancer (BC) patients is generally associated with poor disease prognosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive method for revealing rare circulating cancer cells. The target mRNA must be carefully chosen, as it must be expressed on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Pronzato P,Tognoni A,Falco E,Gianquinto D,Ansaldo V,Dessanti P,Fais F,Rosai J,Fedeli F

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid transporter 2 (LAT2), e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Feng M,Xiong G,Cao Z,Yang G,Zheng S,Qiu J,You L,Zheng L,Zhang T,Zhao Y

更新日期：2018-11-12 00:00:00

abstract：:Increased expression of sialyl Lewis antigens, sLe(a) and sLe(x), is frequent during malignant transformation and tumor progression of gastrointestinal cancers and it is assumed to be correlated with the increased metastatic potential of tumor cells and, consequently, with poor patient survival. To determine the influ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Nakamori S,Nishihara S,Ikehara Y,Nagano H,Dono K,Sakon M,Narimatsu H,Monden M

更新日期：1999-09-01 00:00:00

abstract：:The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA recepto...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tocci P,Blandino G,Bagnato A

更新日期：2021-01-09 00:00:00

abstract：:The aim of this study was to assess the efficiency of the radioguided localization and excision technique using radiopharmaceuticals injected directly or close to occult breast lesions. We studied thirty-two consecutive patients with thirty-six occult breast lesions detected mammographically or ultrasonically categori...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Machado RH,Oliveira AC,Rocha AC,Landesmann MC,Martins FP,Lopes SA,Gutfilen B,da Fonseca LM

更新日期：2007-09-01 00:00:00

abstract：:Few cases of malignant glucagonomas have been described in the literature. In this paper we present a case of a 77-year-old woman with necrolytic migratory erythema and high plasma glucagon and chromogranin A levels caused by a neuroendocrine tumour. An abdominal CT scan suggested a pancreatic lesion and two liver met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Appetecchia M,Ferretti E,Carducci M,Izzo F,Carpanese L,Marandino F,Terzoli E

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect to the International Commission on Radiation Units and Measurements (ICRU) Report 50. METHODS:Forty-fiv...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Andic F,Baz Cifci S,Ors Y,Niang U,Dirier A,Adli M

更新日期：2009-01-07 00:00:00

abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Infante M,Fabi A,Cognetti F,Gorini S,Caprio M,Fabbri A

更新日期：2019-01-08 00:00:00

abstract：:A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Przybylowska K,Zielinska J,Zadrozny M,Krawczyk T,Kulig A,Wozniak P,Rykala J,Kolacinska A,Morawiec Z,Drzewoski J,Blasiak J

更新日期：2004-03-01 00:00:00

abstract：:Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and trea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Vecchione A,Gottardo F,Gomella LG,Wildemore B,Fassan Ms,Bragantini E,Pagano F,Baffa R

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theorie...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Signorile PG,Baldi F,Bussani R,D'Armiento M,De Falco M,Baldi A

更新日期：2009-04-09 00:00:00

abstract：:We evaluated the effect of interferon-alpha2b as a chemosensitiser on HCT-15 cell line in treatment with doxorubicin. Chemosensitivity was determined by [3H]-thymidine incorporation and tetrazolium assays. The levels of expression of P-glycoprotein, Bcl-2 oncoprotein and HLA-ABC complex, and cell cycle/apoptosis analy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lucero Gritti MF,Beviacqua M,Bordenave RH,Rumi LS

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

更新日期：2017-01-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan H,Li H,Li P,Li X,Lin J,Zhu L,Silva MA,Wang X,Wang P,Zhang Z

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have bee...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Solivetti FM,Elia F,Latini A,Cota C,Cordiali-Fei P,Di Carlo A

更新日期：2011-04-13 00:00:00

abstract：BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HCC. In this study, we investigated the functional significance of SNHG12 and explored whether SNHG12 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lan T,Ma W,Hong Z,Wu L,Chen X,Yuan Y

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. MATERIALS AND METHODS:qRT-PCR and western blot were conducted to measure relev...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rong Z,Wang Z,Wang X,Qin C,Geng W

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of various human tumors. With this work we intended to investigate the expression and promoter methylation...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Z,Wang Y,Fang J,Chen F,Liu J,Wu J,Wang Y

更新日期：2010-03-24 00:00:00

abstract：:Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao KM,Chen XC,Zhang JX,Wang Y,Yan W,You YP

更新日期：2015-03-04 00:00:00

abstract：:Escherichia coli cytosine deaminase (CD), which is a prokaryotic enzyme, converts nontoxic prodrug 5-fluorocytosine (5-FC) into the toxic chemotherapeutic agent 5-fluorouracil (5-FU). To investigate an enzyme/prodrug gene therapy for colorectal cancer, using adenoviral gene transfer of the E. coli CD gene associated w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Koyama F,Sawada H,Fujii H,Hirao T,Ueno M,Hamada H,Nakano H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huebner H,Strick R,Wachter DL,Kehl S,Strissel PL,Schneider-Stock R,Hartner A,Rascher W,Horn LC,Beckmann MW,Ruebner M,Fahlbusch FB

更新日期：2017-11-23 00:00:00

abstract：BACKGROUND:A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead to tumor sensitization to chemical and physical agents. The aim of this...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yu DD,Wang CT,Shi HS,Li ZY,Pan L,Yuan QZ,Leng F,Wen Y,Chen X,Wei YQ

更新日期：2010-05-12 00:00:00

abstract：:RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two catalytic subunits which were encoded by MAT2A and MAT2beta respectively. During tumorigeness of hepatocelluar car...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang Q,Liu QY,Liu ZS,Qian Q,Sun Q,Pan DY

更新日期：2008-11-21 00:00:00

abstract：:Tumor ablation by radiofrequency (RFA) is an appealing therapeutical strategy for the treatment of liver tumors (hepatocarcinoma and metastatic lesions) to be used as valid alternative to the surgical resection that often is appropriate and feasible in only a minority of patients. RFA induces the localised and control...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rughetti A,Rahimi H,Rossi P,Frati L,Nuti M,Gaspari A,Danza FM,Ercoli L

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cancer and ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang H,Li S,Yang X,Qiao B,Zhang Z,Xu Y

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review. METHODS:Updated cohort studies on transdermal fentanyl and oral morphi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Xie DR,Jiang ZM,Ma W,Zhang YD,Bi ZF,Chen DL

更新日期：2010-06-09 00:00:00

abstract：:CML is characterized by a reciprocal translocation between the abl and bcr genes on chromosomes 9 and 22 and is usually diagnosed by the presence of the Philadelphia (Ph1) chromosome.However, the translocation may also occur without the appearance of the Ph1 chromosome. In this study the diagnostic efficiency of the m...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yazici H,Sengün Z,Aktan M,Aktuglu G,Uskent N,Dalay N

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at iden...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Meenakshisundaram R,Gragnoli C

更新日期：2009-03-28 00:00:00