Interferon-alpha 2b modulation of doxorubicin sensitivity in a multidrug resistant cell line.

abstract：BACKGROUND:Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Englinger B,Kallus S,Senkiv J,Heilos D,Gabler L,van Schoonhoven S,Terenzi A,Moser P,Pirker C,Timelthaler G,Jäger W,Kowol CR,Heffeter P,Grusch M,Berger W

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim to demonstrate the biological function of ANGPT...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen H,Xiao Q,Hu Y,Chen L,Jiang K,Tang Y,Tan Y,Hu W,Wang Z,He J,Liu Y,Cai Y,Yang Q,Ding K

更新日期：2017-06-12 00:00:00

abstract：:Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine therapy. Mutations in fibroblast growth factor receptor (FGFR) genes have been associated with a higher incidence...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Piasecka D,Braun M,Kitowska K,Mieczkowski K,Kordek R,Sadej R,Romanska H

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin J,Lin W,Ye Y,Wang L,Chen X,Zang S,Huang A

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism of An...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Feng X,Liu H,Zhang Z,Gu Y,Qiu H,He Z

更新日期：2017-09-08 00:00:00

abstract：:A study of laryngeal carcinomas was performed in order to analyze (a) the expression of p53/p21, cyclin D1/cyclin E, p21/p27 (b) the relation of normal and abnormal protein expression, with the proliferation status, as determined by the expression of Ki67 and PCNA and (c) the correlation of our findings with prognosis...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Peschos D,Stefanou D,Vougiouklakis T,Assimakopoulos DA,Agnantis NJ

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The evasion of cell death is one of the hallmarks of cancer, contributing to both tumor progression and resistance to therapy. Dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to conventional anticancer treatments and patients with these tumors are difficult to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Broecker-Preuss M,Viehof J,Jastrow H,Becher-Boveleth N,Fuhrer D,Mann K

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. AIM OF THE STUDY:Present study was designed to study the circular RNA (circRNA) STAT3 in HB. METHODS:Gel electrophoresis revea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu Y,Song J,Liu Y,Zhou Z,Wang X

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available ACh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pfitzinger PL,Fangmann L,Wang K,Demir E,Gürlevik E,Fleischmann-Mundt B,Brooks J,D'Haese JG,Teller S,Hecker A,Jesinghaus M,Jäger C,Ren L,Istvanffy R,Kühnel F,Friess H,Ceyhan GO,Demir IE

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND:Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numerous cancers. However, the underlying mechanisms by which CAF-derived exosomes promote tumor progress...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang X,Qin X,Yan M,Shi J,Xu Q,Li Z,Yang W,Zhang J,Chen W

更新日期：2019-04-08 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. METHODS:Apolipoprotein (ApoE) knock-out mice was used to analyze the intraperitoneal EC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2018-02-20 00:00:00

abstract：:p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the hum...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Egilmez R,Elagöz S,Kanik EA

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:There is no consensus regarding the secondary cytoreduction surgery (CRS) in recurrent ovarian cancer patients. The present study aims to determine the value of secondary CRS and the eligible subgroup for this procedure. METHODS:96 platinum-sensitive recurrent ovarian cancer patients were recruited from Jia...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Xu X,Chen X,Dai Z,Deng F,Qu J,Ni J

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins and cell fusion. In this study,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu K,Zheng M,Zhao Q,Zhang K,Li Z,Fu F,Zhang H,Du J,Li Y,Zhang S

更新日期：2020-05-11 00:00:00

abstract：:To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Vita F,Orditura M,Auriemma A,Infusino S,Catalano G

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosstalk between two pathways is not completely understood. METHODS:The expression of STAT1 protein was ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tian X,Guan W,Zhang L,Sun W,Zhou D,Lin Q,Ren W,Nadeem L,Xu G

更新日期：2018-05-11 00:00:00

abstract：BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Criscuolo D,Morra F,Giannella R,Visconti R,Cerrato A,Celetti A

更新日期：2019-02-22 00:00:00

abstract：:We measured the serum level of soluble Fas (sFas) antigen in gastric MALT (mucosa-associated lymphoid tissue) lymphoma patients to investigate immune response of B lymphoma cells in gastric MALT lymphoma. The serum sFas antigen levels in 21 patients with Helicobacter pylori (HP)-positive MALT lymphoma were 4.51+/-0.25...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Doi T,Nishikawa Y,Endo H,Hosokawa Y,Tanimizu M,Hyodo I

更新日期：1999-09-01 00:00:00

abstract：BACKGROUD:Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS:We performed circRNA microarrays to identify circRNAs that are aberrantly exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He R,Liu P,Xie X,Zhou Y,Liao Q,Xiong W,Li X,Li G,Zeng Z,Tang H

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Anti-angiogenesis remains an attractive strategy for cancer therapy. Some anti-angiogenic reagents have bell-shape dose-response curves with higher than the effective doses yielding lower anti-angiogenic effects. In this study, two different types of anti-angiogenic reagents, a receptor tyrosine kinase inhib...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hu J,Wang W,Liu C,Li M,Nice E,Xu H

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer types, while its regulation in HCC is largely unknown. METHODS:To figure out the specific role of lncRN...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang YG,Wang T,Shi M,Zhai B

更新日期：2019-04-10 00:00:00

abstract：BACKGROUND:Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are overexpressed in many types o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi Y,Sun L,Zhang R,Hu Y,Wu Y,Dong X,Dong D,Chen C,Geng Z,Li E,Fan Y

更新日期：2021-01-06 00:00:00

abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Infante M,Fabi A,Cognetti F,Gorini S,Caprio M,Fabbri A

更新日期：2019-01-08 00:00:00

abstract：:Accumulating evidence suggests that radiation treatment causes an adaptive response of lung adenocarcinoma (LUAD), which in turn attenuates the lethal effect of the irradiation. Previous microarray assays manifested the change of gene expression profile after irradiation. Bioinformatics analysis of the significantly c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hao CC,Xu CY,Zhao XY,Luo JN,Wang G,Zhao LH,Ge X,Ge XF

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit anti-cancer effects....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zong L,Chen K,Jiang Z,Chen X,Sun L,Ma J,Zhou C,Xu Q,Duan W,Han L,Lei J,Li X,Ma Q,Wang Z

更新日期：2017-12-11 00:00:00

abstract：:Our previous studies have demonstrated the significant enzymatic activity of glycogen phosphorylase (GP) in the gastric carcinoma and proliferating cells of particular intestinal metaplasia (IM). This paper reviewed the identification of the GP isoform in the gastrointestinal carcinoma, and the investigation on the ro...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shimada S,Tashima S,Yamaguchi K,Matsuzaki H,Ogawa M

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Agonistic CD40 antibodies have been demonstrated to activate antigen-presenting cells (APCs) and enhance antitumour T cell responses, thereby providing a new therapeutic option in cancer immunotherapy. In agonistic CD40 antibody-mediated inflammatory responses, a novel subset of E-cadherin + dendritic cells ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Hu X,Hu Y,Teng K,Zhang K,Zheng Y,Hong X,Yu K,Wang Y,Liu L

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hyakusoku H,Sano D,Takahashi H,Hatano T,Isono Y,Shimada S,Ito Y,Myers JN,Oridate N

更新日期：2016-01-12 00:00:00

abstract：:Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the specific complex named shelterin and a tight nucleosomal organizati...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cacchione S,Biroccio A,Rizzo A

更新日期：2019-01-17 00:00:00