Serum concentrations of proinflammatory cytokines in advanced non small cell lung cancer patients.

Abstract:

:To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean cytokines concentrations in patients were significantly higher than in the control population. Patients with metastatic disease had higher levels than those with undisseminated disease. Finally, in patients with tumor progression we observed an increase of cytokines serum levels. These results suggest that in NSCLC elevated serum levels of proinflammatory cytokines may have prognostic value being associated with a worse prognosis.

journal_name

J Exp Clin Cancer Res

authors

De Vita F,Orditura M,Auriemma A,Infusino S,Catalano G

keywords:

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

413-7

issue

4

eissn

0392-9078

issn

1756-9966

journal_volume

17

pub_type

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