当前位置： SCI文献检索 > JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH期刊下所有文献 > Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma.

Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma.

Abstract：

:Accumulating evidence suggests that radiation treatment causes an adaptive response of lung adenocarcinoma (LUAD), which in turn attenuates the lethal effect of the irradiation. Previous microarray assays manifested the change of gene expression profile after irradiation. Bioinformatics analysis of the significantly changed genes revealed that VANGL1 may notably influence the effect of radiation on LUAD. To determine the role of VANGL1, this study knocked down or overexpressed VANGL1 in LUAD. M6A level of VANGL1 mRNA was determined by M6A-IP-qPCR assay. Irradiation caused the up-regulation of VANGL1 with the increase of VANGL1 m6A level. Depletion of m6A readers, IGF2BP2/3, undermined VANGL1 mRNA stability and expression upon irradiation. miR-29b-3p expression was decreased by irradiation, however VANGL1 is a target of miR-29b-3p which was identified by Luciferase report assay. The reduction of miR-29b-3p inhibited the degradation of VANGL1 mRNA. Knockdown of VANGL1 enhanced the detrimental effect of irradiation on LUAD, as indicated by more severe DNA damage and increased percentage of apoptotic cells. Immunocoprecipitation revealed the interaction between VANGL1 with BRAF. VANGL1 increased BRAF probably through suppressing the protein degradation, which led to the increase of BRAF downstream effectors, TP53BP1 and RAD51. These effectors are involved in DNA repair after the damage. In summary, irradiation caused the up-regulation of VANGL1, which, in turn, mitigated the detrimental effect of irradiation on LUAD by protecting DNA from damage probably through activating BRAF/TP53BP1/RAD51 cascades. Increased m6A level of VANGL1 and reduced miR-29b-3p took the responsibility of VANGL1 overexpression upon irradiation.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Hao CC,Xu CY,Zhao XY,Luo JN,Wang G,Zhao LH,Ge X,Ge XF

doi

10.1186/s13046-020-01772-y

subject

Has Abstract

pub_date

2020-11-23 00:00:00

pages

256

issue

1

eissn

0392-9078

issn

1756-9966

pii

10.1186/s13046-020-01772-y

journal_volume

39

pub_type

杂志文章

相关文献

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH文献大全
  • ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis.

    abstract：BACKGROUND:The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents against this disease is urgent. Salinomycin induces broad anti-cancer effects; however, its role in GBM and the...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-015-0174-1

    authors： Qin LS,Jia PF,Zhang ZQ,Zhang SM

    更新日期：2015-05-30 00:00:00

  • Turcot syndrome: case report and nosological aspects.

    abstract：:The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submit...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Fracasso P,Caviglia R,Grassi A,Lapenta R,Stigliano V,Franco D,Casale V

    更新日期：1997-12-01 00:00:00

  • Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.

    abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) remain mostly unknown. METHODS:In this study, quantitative real-time PCR (qPCR) and western blotting ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01633-8

    authors： Yang T,Chen WC,Shi PC,Liu MR,Jiang T,Song H,Wang JQ,Fan RZ,Pei DS,Song J

    更新日期：2020-07-20 00:00:00

  • Correction to: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer.

    abstract：:In the original publication of this manuscript [1], Fig. 5E lower panel was incorrect due to an error in the preparation of these figures for publication. It was noticed that in the lower panel of Fig. 5E, one mouse image of ApoE-/- + PBS group (upper) was a photograph coming from ApoE-/- + BAPN pre-treatment group (l...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 已发布勘误

    doi：10.1186/s13046-019-1422-6

    authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

    更新日期：2019-10-15 00:00:00

  • circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.

    abstract：BACKGROUD:Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is largely unknown. METHODS:We performed circRNA microarrays to identify circRNAs that are aberrantly exp...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-017-0614-1

    authors： He R,Liu P,Xie X,Zhou Y,Liao Q,Xiong W,Li X,Li G,Zeng Z,Tang H

    更新日期：2017-10-16 00:00:00

  • The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer.

    abstract：:Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical tri...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/s13046-019-1172-5

    authors： Yan Y,Chen X,Wang X,Zhao Z,Hu W,Zeng S,Wei J,Yang X,Qian L,Zhou S,Sun L,Gong Z,Xu Z

    更新日期：2019-04-23 00:00:00

  • Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.

    abstract：BACKGROUND:Microtubule Targeting Agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are widely used in the treatment of various cancers. As with most chemotherapeutic agents, adverse effects and drug resistance are commonly associated with the clinical use of these agents. Methyl 2-(5-fluoro-2-hydroxyph...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-016-0332-0

    authors： Hasanpourghadi M,Karthikeyan C,Pandurangan AK,Looi CY,Trivedi P,Kobayashi K,Tanaka K,Wong WF,Mustafa MR

    更新日期：2016-03-31 00:00:00

  • Sequential deletions in both arms of chromosome 9 are associated with the development of head and neck squamous cell carcinoma in Indian patients.

    abstract：:In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient population by microsatellite markers, we have identified four discrete areas (D1-D4) with high loss of heterozygosities (LOHs) viz. 9p24-p23 (D1), 9p22-p21 (D2), 9q11-q13 (D3) and 9q22.3 (D4) regions. The deletions in D2 and D...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 历史文章,杂志文章

    doi：

    authors： Tripathi A,Dasgupta S,Roy A,Sengupta A,Roy B,Roychowdhury S,Panda CK

    更新日期：2003-06-01 00:00:00

  • p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.

    abstract：BACKGROUND:Berberine (BBR), a component from traditional Chinese medicine, has been shown to possess anti-tumor activity against a wide spectrum of cancer cells including human lung cancer, but the detailed mechanism underlining this has not been well elucidated. METHODS:In this study, the effect of berberine on cell ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-33-36

    authors： Zheng F,Tang Q,Wu J,Zhao S,Liang Z,Li L,Wu W,Hann S

    更新日期：2014-04-26 00:00:00

  • Pleomorphic adenoma of cervical heterotopic salivary glands.

    abstract：:Neoplastic transformation of heterotopic cervical salivary gland tissue is extremely rare. The Authors describe a case of pleomorphic adenoma arising in this tissue, on the right side of the neck in a 40-year old man. The characteristics of salivary heterotipias of the neck, and their diagnostic difficulties and histo...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Baldi A,Persichetti P,Di Marino MP,Nicoletti G,Baldi F

    更新日期：2003-12-01 00:00:00

  • Oncogene addiction in gliomas: implications for molecular targeted therapy.

    abstract：:Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated sys...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/1756-9966-30-58

    authors： Yan W,Zhang W,Jiang T

    更新日期：2011-05-17 00:00:00

  • Human plasma antioxidant capacity during radiotherapy for lung cancer: a clinical study.

    abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 临床试验,杂志文章

    doi：

    authors： Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

    更新日期：1998-09-01 00:00:00

  • Combined effect of arsenic trioxide and sulindac sulfide in A549 human lung cancer cells in vitro.

    abstract：:Arsenic trioxide has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukemia (APL) as well as solid tumors. Arsenic can act through a considerable number of different pathways including mitochondrial respiration and tubulin formation, affecting growth, blood flow, diffe...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Jiang TT,Brown SL,Kim JH

    更新日期：2004-06-01 00:00:00

  • Down-regulated miR-9 and miR-433 in human gastric carcinoma.

    abstract：BACKGROUND:MircoRNAs(miRNAs) are short, endogenously non-coding RNAs. The abnormal expression of miRNAs may be valuable for the diagnosis and treatment of tumors. METHODS:To screening the special miRNAs in gastric carcinoma, expression level of miRNAs in gastric carcinoma and normal gaster samples were detected by miR...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-28-82

    authors： Luo H,Zhang H,Zhang Z,Zhang X,Ning B,Guo J,Nie N,Liu B,Wu X

    更新日期：2009-06-16 00:00:00

  • Stimulation of megakaryocytopoiesis and platelet production during growth of an experimental lymphoma.

    abstract：:The effect of malignant tumor growth on host's megakaryocytopoiesis and platelet production was studied in mice bearing transplantable Dalton's lymphoma. Tumor growth was paralleled by thrombocytosis, neutrophilia, and anemia. Platelet 51Cr half-life was normal but incorporation of 75Selenomethionine into circulating ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Ray MR

    更新日期：2000-12-01 00:00:00

  • Incomplete operative removal of colorectal liver metastases followed by chemotherapy decreases survival in comparison to chemotherapy alone.

    abstract：:Metastatic colorectal carcinoma (CRC) has an inevitable fatal outcome except in a small percentage of selected patients, approximately 10-20%, with good prognosis after successful complete operative removal of the liver metastases. In patients not eligible for surgical resection of the liver metastases, chemotherapy i...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Popov IP,Milicevic M,Kecmanovic D,Tomasevic Z,Radosevic-Jelic Lj,Borojevic N,Micev MT,Kezic I

    更新日期：2006-09-01 00:00:00

  • Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer.

    abstract：BACKGROUND:The human epidermal growth factor receptor 2 (HER2) and p53 pathways may be involved in chemotherapy sensitivity and/or resistance. We explore the value of HER2 and p53 status to foretell docetaxel sensitivity in advanced breast cancer. METHODS:HER2 and p53 expression was analysed in 36 (median age 55 yrs; ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-30-38

    authors： Camerini A,Donati S,Viacava P,Siclari O,Puccetti C,Tartarelli G,Valsuani C,De Luca F,Martini L,Cavazzana A,Amoroso D

    更新日期：2011-04-11 00:00:00

  • Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma.

    abstract：BACKGROUND:Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hy...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-017-0634-x

    authors： Huebner H,Strick R,Wachter DL,Kehl S,Strissel PL,Schneider-Stock R,Hartner A,Rascher W,Horn LC,Beckmann MW,Ruebner M,Fahlbusch FB

    更新日期：2017-11-23 00:00:00

  • Detection of CD44 variants in fine needle aspiration biopsies of thyroid tumor by RT-PCR.

    abstract：:Increased expression of CD44 variants is often observed in differentiated thyroid carcinomas. To establish a method for gene diagnosis of thyroid without any additional invasions to the patients, RNA in leftover cells inside the needle used for fine needle aspiration biopsies (FNABs) was extracted to detect the expres...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Takano T,Sumizaki H,Amino N

    更新日期：1997-09-01 00:00:00

  • Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression.

    abstract：BACKGROUND:Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. MATERIALS AND METHODS:qRT-PCR and western blot were conducted to measure relev...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01551-9

    authors： Rong Z,Wang Z,Wang X,Qin C,Geng W

    更新日期：2020-04-09 00:00:00

  • Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification.

    abstract：BACKGROUND:This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast cancer with equivocal HER2 expression by immunohistochemistry and HER2 gene signals/nucleus (s/n) rangi...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-017-0613-2

    authors： Ercolani C,Marchiò C,Di Benedetto A,Fabi A,Perracchio L,Vici P,Sperati F,Buglioni S,Arena V,Pescarmona E,Sapino A,Terrenato I,Mottolese M

    更新日期：2017-10-13 00:00:00

  • Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.

    abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1044-z

    authors： Fan P,Zhao J,Meng Z,Wu H,Wang B,Wu H,Jin X

    更新日期：2019-02-01 00:00:00

  • Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma.

    abstract：:Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1756-9966-29-78

    authors： Ye F,Yu Y,Hu Y,Lu W,Xie X

    更新日期：2010-06-18 00:00:00

  • Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.

    abstract：BACKGROUND:Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also e...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-018-0837-9

    authors： Chen HY,Islam A,Yuan TM,Chen SW,Liu PF,Chueh PJ

    更新日期：2018-07-20 00:00:00

  • Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA.

    abstract：:RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two catalytic subunits which were encoded by MAT2A and MAT2beta respectively. During tumorigeness of hepatocelluar car...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-27-72

    authors： Wang Q,Liu QY,Liu ZS,Qian Q,Sun Q,Pan DY

    更新日期：2008-11-21 00:00:00

  • Activity and toxicity of oxaliplatin and bolus fluorouracil plus leucovorin in pretreated colorectal cancer patients: a phase II study.

    abstract：:The aim of the current study was to evaluate the activity and toxicity of a combination of oxaliplatin with bolus fluorouracil and leucovorin in colorectal cancer (CRC) patients pretreated for advanced disease with various schedules including continuous fluorouracil infusion. Thirty consecutive patients with pretreate...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 临床试验,杂志文章

    doi：

    authors： Ferraresi V,Giampaolo MA,Gabriele A,Mansueto G,Buccilli A,Giannarelli D,Ciccarese M,Gamucci T

    更新日期：2005-06-01 00:00:00

  • Low dose-intensity docetaxel in the treatment of pre-treated elderly patients with metastatic breast cancer.

    abstract：:We evaluated the efficacy and toxicity profile of single-agent docetaxel administered in daily clinical practice at low-dose regimen in 37 pre-treated elderly patients with metastatic breast cancer previously exposed to chemotherapy. Docetaxel was employed by physician's preference according to a weekly (8 patients, 2...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 临床试验,杂志文章

    doi：

    authors： Massacesi C,Marcucci F,Boccetti T,Battelli N,Pilone A,Rocchi MB,Bonsignori M

    更新日期：2005-03-01 00:00:00

  • Whole brain radiotherapy with radiosensitizer for brain metastases.

    abstract：PURPOSE:To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of treatment. METHODS:A meta-analysis of randomized controlled trials (RCT)...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,meta分析

    doi：10.1186/1756-9966-28-1

    authors： Viani GA,Manta GB,Fonseca EC,De Fendi LI,Afonso SL,Stefano EJ

    更新日期：2009-01-06 00:00:00

  • Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation.

    abstract：BACKGROUND:Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available ACh...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01796-4

    authors： Pfitzinger PL,Fangmann L,Wang K,Demir E,Gürlevik E,Fleischmann-Mundt B,Brooks J,D'Haese JG,Teller S,Hecker A,Jesinghaus M,Jäger C,Ren L,Istvanffy R,Kühnel F,Friess H,Ceyhan GO,Demir IE

    更新日期：2020-12-24 00:00:00

  • CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study.

    abstract：BACKGROUND:Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at iden...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-28-42

    authors： Meenakshisundaram R,Gragnoli C

    更新日期：2009-03-28 00:00:00