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Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma.

Abstract：

:Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-beta in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Ye F,Yu Y,Hu Y,Lu W,Xie X

doi

10.1186/1756-9966-29-78

subject

Has Abstract

pub_date

2010-06-18 00:00:00

pages

78

eissn

0392-9078

issn

1756-9966

pii

1756-9966-29-78

journal_volume

29

pub_type

杂志文章,随机对照试验

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