Enhancement of cisplatin sensitivity in Lewis Lung carcinoma by liposome-mediated delivery of a survivin mutant.

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) accompanied by the downregulation of E-cadherin has been thought to promote metastasis. Cyclooxygenase-2 (Cox-2) is presumed to contribute to cancer progression through its multifaceted function, and recently its inverse relationship with E-cadherin was suggeste...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fujii R,Imanishi Y,Shibata K,Sakai N,Sakamoto K,Shigetomi S,Habu N,Otsuka K,Sato Y,Watanabe Y,Ozawa H,Tomita T,Kameyama K,Fujii M,Ogawa K

更新日期：2014-05-10 00:00:00

abstract：:After aggressive surgery and chemotherapy, patients (PTS) with advanced solid tumors have often an impaired immune function that may facilitate tumor relapse. We have demonstrated, in a phase IB study, that administering low-dose interleukin-2 (IL-2) and 13-cis retinoic acid (RA), there was a significant improvement o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Recchia F,Cesta A,Rea S

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Yu X,Zhang Z,Pang L,Xu J,Jiang J,Liang W,Chai Y,Hou J,Li F

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of various human tumors. With this work we intended to investigate the expression and promoter methylation...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Z,Wang Y,Fang J,Chen F,Liu J,Wu J,Wang Y

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Z,Zhou C,Cheng L,Yan B,Chen K,Chen X,Zong L,Lei J,Duan W,Xu Q,Li X,Wang Z,Ma Q,Ma J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA). METHODS:mRNAs extracted from 35 pancreatic tubular adenocarcinoma tissues obtained by E...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ashida R,Nakata B,Shigekawa M,Mizuno N,Sawaki A,Hirakawa K,Arakawa T,Yamao K

更新日期：2009-06-16 00:00:00

abstract：:Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ye F,Yu Y,Hu Y,Lu W,Xie X

更新日期：2010-06-18 00:00:00

abstract：BACKGROUND:Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofib...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Umezu H,Endo N

更新日期：2009-03-31 00:00:00

abstract：:p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the hum...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Egilmez R,Elagöz S,Kanik EA

更新日期：2001-12-01 00:00:00

abstract：:The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequenci...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Grillone K,Riillo C,Scionti F,Rocca R,Tradigo G,Guzzi PH,Alcaro S,Di Martino MT,Tagliaferri P,Tassone P

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known as a hallmark of canc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huang Q,Wang Q,Li D,Wei X,Jia Y,Zhang Z,Ai B,Cao X,Guo T,Liao Y

更新日期：2019-03-15 00:00:00

abstract：:Radionuclide therapy with bone seeking radiopharmaceuticals is one of the oldest interventions in nuclear medicine and has been now in use for many years as an effective method of palliating painful bone metastases. Clinical indications have slowly but progressively increased starting from end-stage prostate cancer wi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maini CL,Sciuto R,Romano L,Bergomi S

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numerous cancers. However, the underlying mechanisms by which CAF-derived exosomes promote tumor progress...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang X,Qin X,Yan M,Shi J,Xu Q,Li Z,Yang W,Zhang J,Chen W

更新日期：2019-04-08 00:00:00

abstract：:The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results were inconclusive and controversial. Our aim of this study was to evaluate this association by literature base...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Xie Y,Xian L

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin J,Lin W,Ye Y,Wang L,Chen X,Zang S,Huang A

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:alpha-Methylacyl-CoA racemase (AMACR), an immunomarker for prostatic adenocarcinoma, has been shown to be expressed in a variety of other neoplasms. This study aims to evaluate immunohistochemical expression of the AMACR in neoplastic and nonneoplastic liver lesions, and assess its value in the diagnosis of ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li W,Cagle PT,Botero RC,Liang JJ,Zhang Z,Tan D

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused with HBx and upstream 56 amino acid, in HCC. In current study, the molecular functions of HBwx in H...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Liu H,Yi R,Yan T,He Y,Zhao Y,Liu J

更新日期：2016-06-03 00:00:00

abstract：:The authors report one case of cauda equina paraganglioma and review the neurosurgical, radiological and pathological literatureon this rare tumour. Although it is difficult to distinguish preoperatively the paraganglioma from other tumours of the cauda equina, like neurinoma or ependymoma, this neuroendocrine tumour ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Caruso R,Wierzbicki V,Marrocco L,Salvati M

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood. METHODS:Quantitative real-time PCR (RT-qPCR) and western blot were performed to detect the expression of MeCP2 in glio...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bian E,Chen X,Xu Y,Ji X,Cheng M,Wang H,Fang Z,Zhao B

更新日期：2019-08-20 00:00:00

abstract：:Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guidelines, many questions are still open. Among them, it should be acknowledged that the treatment for stage IB d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bonomi M,Pilotto S,Milella M,Massari F,Cingarlini S,Brunelli M,Chilosi M,Tortora G,Bria E

更新日期：2011-12-29 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：INTRODUCTION:Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of several molecular markers in breast cancer has been of considerable interest during recent years suc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Mao XY,Fan CF,Zheng HC,Wei J,Yao F,Jin F

更新日期：2010-08-16 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast ca...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tao S,Chen Q,Lin C,Dong H

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Englinger B,Kallus S,Senkiv J,Heilos D,Gabler L,van Schoonhoven S,Terenzi A,Moser P,Pirker C,Timelthaler G,Jäger W,Kowol CR,Heffeter P,Grusch M,Berger W

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10-15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development. METHODS:We examined...

journal_title：Journal of experimental & clinical cancer research : CR

authors： D'Angelo V,Iannotta A,Ramaglia M,Lombardi A,Zarone MR,Desiderio V,Affinita MC,Pecoraro G,Di Martino M,Indolfi P,Casale F,Caraglia M

更新日期：2015-08-14 00:00:00

abstract：:In the original publication of this manuscript [1], Fig. 1 contained a typographical error ('Metabolic' incorrectly written as 'Metabolig'). ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bosco MC,Orazi G,Del Bufalo D

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to assess whether isovitexin inhibits hepatic carcinoma stem-like cells (HCSLCs) features via regulating Mn...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao X,Liu L,Yuan Q,Li X,Cui Y,Ren K,Zou C,Chen A,Xu C,Qiu Y,Quan M,Zhang J,Cao J,Chen X

更新日期：2019-06-17 00:00:00

abstract：:This case report describes a rare presentation of penile melanoma in which 3 successive primaries arose and were operated from an area of melanosis on the glans penis and prepuce. One of the major factors accounting for the poor prognosis of this patient was the long delay in presentation. This was largely due to the ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Testori A,Mazzarol G,Viale G,De Cobelli O,Lotti M,Rocco F,Andreoni B

更新日期：1999-06-01 00:00:00

abstract：UNLABELLED:In order to evaluate the influence of time intervals between tumor cell injection and radiotherapy on tumor control and regrowth after surgery, we performed two kinds of experiments on C3D2F1 mice bearing a mammary carcinoma inoculated in the foot or leg. 1st experiment: tumor in foot. END POINT:Tumor Contr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cividalli A,Creton G,Ceciarelli F,Strigari L,Tirindelli Danesi D,Benassi M

更新日期：2005-03-01 00:00:00