当前位置： SCI文献检索 > JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH期刊下所有文献 > A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma.

A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma.

Abstract：

BACKGROUND:The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood. METHODS:Quantitative real-time PCR (RT-qPCR) and western blot were performed to detect the expression of MeCP2 in glioma tissues and cell lines. MeCP2 functions were tested with cell immunofluorescence staining and western blot. For in vivo experiments, mouse xenograft model was used to investigate the effects of MeCP2 on glioma. ChIP and Co-IP were used to detect the relationships among MeCP2, miR-200c and Suv39H1. RESULTS:In this study, we found that MeCP2 was frequently up-regulated in human glioma tissues and cell lines. MeCP2 knockdown remarkably induced cell epithelial phenotype and inhibited mesenchymal marker ZEB1 and ZEB2 in vitro and in vivo. In addition, MeCP2 in glioma tissues was negatively correlated with miR-200c expression, and miR-200c overexpression partially abrogated mesenchymal phenotype induced by MeCP2. More importantly, we showed that MeCP2 recruited H3K9 to the promoter of miR-200c by interacting with SUV39H1, resulting in EMT of glioma cells. CONCLUSIONS:This study for the first time reveals MeCP2 as a novel regulator of EMT in glioma and suggest that MeCP2 inhibition may represent a promising therapeutic option for suppressing EMT in glioma.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Bian E,Chen X,Xu Y,Ji X,Cheng M,Wang H,Fang Z,Zhao B

doi

10.1186/s13046-019-1341-6

subject

Has Abstract

pub_date

2019-08-20 00:00:00

pages

366

issue

1

eissn

0392-9078

issn

1756-9966

pii

10.1186/s13046-019-1341-6

journal_volume

38

pub_type

杂志文章

相关文献

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH文献大全
  • Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis.

    abstract：BACKGROUND:The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these biomarkers in breast cancer metastasis and prognosis. METHODS:The CXCR4, CCR7, CXCL12, CCL21, and EG...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-29-16

    authors： Liu Y,Ji R,Li J,Gu Q,Zhao X,Sun T,Wang J,Li J,Du Q,Sun B

    更新日期：2010-02-24 00:00:00

  • Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation.

    abstract：BACKGROUND:Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available ACh...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01796-4

    authors： Pfitzinger PL,Fangmann L,Wang K,Demir E,Gürlevik E,Fleischmann-Mundt B,Brooks J,D'Haese JG,Teller S,Hecker A,Jesinghaus M,Jäger C,Ren L,Istvanffy R,Kühnel F,Friess H,Ceyhan GO,Demir IE

    更新日期：2020-12-24 00:00:00

  • Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway.

    abstract：BACKGROUND:Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast ca...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01676-x

    authors： Tao S,Chen Q,Lin C,Dong H

    更新日期：2020-09-17 00:00:00

  • Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.

    abstract：:We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

    更新日期：2000-09-01 00:00:00

  • Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients.

    abstract：BACKGROUND:To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian cancer patients. METHODS:Semi-quantitative RT-PCR and western blot were applied to detect the express...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-29-85

    authors： Ma Y,Ma L,Guo Q,Zhang S

    更新日期：2010-06-30 00:00:00

  • Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.

    abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,撤回出版物

    doi：10.1186/s13046-020-01668-x

    authors： Li Z,Zhang L,Gao M,Han M,Liu K,Zhang Z,Gong Z,Xing L,Shi X,Lu K,Gao H

    更新日期：2020-08-19 00:00:00

  • Amelioration of cisplatin induced nephrotoxicity in mice by ethyl acetate extract of a polypore fungus, Phellinus rimosus.

    abstract：:Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Ajith TA,Jose N,Janardhanan KK

    更新日期：2002-06-01 00:00:00

  • Physical interaction of STAT1 isoforms with TGF-β receptors leads to functional crosstalk between two signaling pathways in epithelial ovarian cancer.

    abstract：BACKGROUND:The signal transducer and activator of transcription (STAT) and transforming growth factor-β (TGF-β) signaling pathways play important roles in epithelial ovarian cancer (EOC). However, the mechanism of crosstalk between two pathways is not completely understood. METHODS:The expression of STAT1 protein was ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-018-0773-8

    authors： Tian X,Guan W,Zhang L,Sun W,Zhou D,Lin Q,Ren W,Nadeem L,Xu G

    更新日期：2018-05-11 00:00:00

  • NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues.

    abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-kappaB) is a family of the genes that includes five members acting in events such as inflammat...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-27-53

    authors： Meteoglu I,Erdogdu IH,Meydan N,Erkus M,Barutca S

    更新日期：2008-10-19 00:00:00

  • Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis.

    abstract：BACKGROUND:Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a major component of TJs. However, the clinical significance and its regulation of kidney tumorigenesis...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-018-0924-y

    authors： Li Y,Gong Y,Ning X,Peng D,Liu L,He S,Gong K,Zhang C,Li X,Zhou L

    更新日期：2018-11-14 00:00:00

  • Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.

    abstract：:Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor progression, metastatization and resistance to therapy. New immunotherapeutic approaches aim at restorin...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/s13046-020-01586-y

    authors： Galli F,Aguilera JV,Palermo B,Markovic SN,Nisticò P,Signore A

    更新日期：2020-05-18 00:00:00

  • AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?

    abstract：BACKGROUND:Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have bee...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-30-40

    authors： Solivetti FM,Elia F,Latini A,Cota C,Cordiali-Fei P,Di Carlo A

    更新日期：2011-04-13 00:00:00

  • sE-cadherin serves as a diagnostic and predictive parameter in prostate cancer patients.

    abstract：BACKGROUND:Measurement of prostate-specific antigen (PSA) advanced the diagnostic and prognostic potential for prostate cancer (PCa). However, due to PSA's lack of specificity, novel biomarkers are needed to improve risk assessment and ensure optimal personalized therapy. A set of protein molecules as potential biomark...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-015-0161-6

    authors： Tsaur I,Thurn K,Juengel E,Gust KM,Borgmann H,Mager R,Bartsch G,Oppermann E,Ackermann H,Nelson K,Haferkamp A,Blaheta RA

    更新日期：2015-05-14 00:00:00

  • Restoration of LRIG1 suppresses bladder cancer cell growth by directly targeting EGFR activity.

    abstract：BACKGROUND:Recently, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, was discovered is a novel agent for suppressing bladder cancer. The aim of this study was to investigate the impact of LRIG1 on the biological features of aggressive bladder cancer cells and the possible m...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-32-101

    authors： Chang L,Shi R,Yang T,Li F,Li G,Guo Y,Lang B,Yang W,Zhuang Q,Xu H

    更新日期：2013-12-08 00:00:00

  • Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.

    abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) remain mostly unknown. METHODS:In this study, quantitative real-time PCR (qPCR) and western blotting ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01633-8

    authors： Yang T,Chen WC,Shi PC,Liu MR,Jiang T,Song H,Wang JQ,Fan RZ,Pei DS,Song J

    更新日期：2020-07-20 00:00:00

  • UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.

    abstract：BACKGROUND:Ubiquitin-like protein 4A (UBL4A) plays a significant role in protein metabolism and the maintenance of cellular homeostasis. In cancer, UBL4A represses tumorigenesis and is involved in various signaling pathways. Pancreatic ductal adenocarcinoma (PDAC) is still a major cause of cancer-related death and the ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1278-9

    authors： Chen H,Li L,Hu J,Zhao Z,Ji L,Cheng C,Zhang G,Zhang T,Li Y,Chen H,Pan S,Sun B

    更新日期：2019-07-09 00:00:00

  • Efficient inhibition of murine breast cancer growth and metastasis by gene transferred mouse survivin Thr34-->Ala mutant.

    abstract：BACKGROUND:Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (IAP) family, survivin has been proposed as an attractive target for new anticancer interventions. In...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-27-46

    authors： Peng XC,Yang L,Yang LP,Mao YQ,Yang HS,Liu JY,Zhang DM,Chen LJ,Wei YQ

    更新日期：2008-09-25 00:00:00

  • Influencing factors and clinical significance of the metastatic lymph nodes ratio in gastric adenocarcinoma.

    abstract：BACKGROUND:To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. METHODS:We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. T...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-28-55

    authors： Yu JW,Wu JG,Zheng LH,Zhang B,Ni XC,Li XQ,Jiang BJ

    更新日期：2009-04-26 00:00:00

  • Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are primary resistant to EGFR-TKIs such as gefitinib. Curcumin has been known as a potential t...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1234-8

    authors： Chen P,Huang HP,Wang Y,Jin J,Long WG,Chen K,Zhao XH,Chen CG,Li J

    更新日期：2019-06-13 00:00:00

  • The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells.

    abstract：BACKGROUND:Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prosta...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-28-100

    authors： Li H,Ruan G,Li Z,Liu Z,Zheng X,Zheng H,Cheng G,Li B,Zhan M

    更新日期：2009-07-14 00:00:00

  • Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer.

    abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to treatment inevitably occurs. Given lipid metabolic reprogramming is widely known as a hallmark of canc...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1120-4

    authors： Huang Q,Wang Q,Li D,Wei X,Jia Y,Zhang Z,Ai B,Cao X,Guo T,Liao Y

    更新日期：2019-03-15 00:00:00

  • Endoscopic palliative therapy in neoplastic diseases of the esophagus.

    abstract：:Over the past 20 years, fiberoptic endoscopy, followed by video-endoscopy, has taken on an increasingly important role in the diagnostics and therapy for digestive tract diseases. Especially in the field of oncology, endoscopy is fundamental not only for the diagnosis and staging of diseases of the gastroenteric tract...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：

    authors： Casale V,Lapenta R,Gigliozzi A,Villotti G

    更新日期：1999-03-01 00:00:00

  • Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway.

    abstract：BACKGROUND:m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including CRC. Here, we investigate m6A modification and the underlying mechanism of METTL3 in the developmen...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1408-4

    authors： Peng W,Li J,Chen R,Gu Q,Yang P,Qian W,Ji D,Wang Q,Zhang Z,Tang J,Sun Y

    更新日期：2019-09-06 00:00:00

  • NR1B2 suppress kidney renal clear cell carcinoma (KIRC) progression by regulation of LATS 1/2-YAP signaling.

    abstract：BACKGROUND:Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role of NR1B2 in KIRC. METHODS:NR1B2 expression in TCGA dat...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1344-3

    authors： Yin L,Li W,Wang G,Shi H,Wang K,Yang H,Peng B

    更新日期：2019-08-07 00:00:00

  • Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation.

    abstract：BACKGROUND:Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The latter can be induce...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1164-5

    authors： Mele L,la Noce M,Paino F,Regad T,Wagner S,Liccardo D,Papaccio G,Lombardi A,Caraglia M,Tirino V,Desiderio V,Papaccio F

    更新日期：2019-04-12 00:00:00

  • Inhibition of hepatocelluar carcinoma MAT2A and MAT2beta gene expressions by single and dual small interfering RNA.

    abstract：:RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two catalytic subunits which were encoded by MAT2A and MAT2beta respectively. During tumorigeness of hepatocelluar car...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-27-72

    authors： Wang Q,Liu QY,Liu ZS,Qian Q,Sun Q,Pan DY

    更新日期：2008-11-21 00:00:00

  • Molecular mechanism involved in increased expression of sialyl Lewis antigens in ductal carcinoma of the pancreas.

    abstract：:Increased expression of sialyl Lewis antigens, sLe(a) and sLe(x), is frequent during malignant transformation and tumor progression of gastrointestinal cancers and it is assumed to be correlated with the increased metastatic potential of tumor cells and, consequently, with poor patient survival. To determine the influ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Nakamori S,Nishihara S,Ikehara Y,Nagano H,Dono K,Sakon M,Narimatsu H,Monden M

    更新日期：1999-09-01 00:00:00

  • Activity and toxicity of oxaliplatin and bolus fluorouracil plus leucovorin in pretreated colorectal cancer patients: a phase II study.

    abstract：:The aim of the current study was to evaluate the activity and toxicity of a combination of oxaliplatin with bolus fluorouracil and leucovorin in colorectal cancer (CRC) patients pretreated for advanced disease with various schedules including continuous fluorouracil infusion. Thirty consecutive patients with pretreate...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 临床试验,杂志文章

    doi：

    authors： Ferraresi V,Giampaolo MA,Gabriele A,Mansueto G,Buccilli A,Giannarelli D,Ciccarese M,Gamucci T

    更新日期：2005-06-01 00:00:00

  • Detection of t(14;18), P53 and RAS gene mutations and quantification of residual disease in patients with B-cell non-Hodgkin's lymphoma.

    abstract：UNLABELLED:PCR analysis has been demonstrated as a valuable tool for detection of minimal residual disease (MRD) in lymphoid malignancies. However, the finding that patients with evidence of MRD sometimes remain in long-lasting remission directs further investigations toward biology of residual disease and/or quantific...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Cikota BM,Tukić LJ,Tarabar OT,Magić ZM

    更新日期：2007-12-01 00:00:00

  • Whole brain radiotherapy with radiosensitizer for brain metastases.

    abstract：PURPOSE:To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of treatment. METHODS:A meta-analysis of randomized controlled trials (RCT)...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,meta分析

    doi：10.1186/1756-9966-28-1

    authors： Viani GA,Manta GB,Fonseca EC,De Fendi LI,Afonso SL,Stefano EJ

    更新日期：2009-01-06 00:00:00