Abstract:
:Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hCT) for 3-6 months. Nine of our patients showed biochemical improvement during the first 2 months of treatment, with reduction in ALP and uHOP . In one patient with slightly increased ALP and uHOP , and in another one during the second treatment course, hCT treatment did not modify the biochemical indices of bone disease. However all patients, including those with biochemical resistance, experienced a remarkable diminution of bone pain, which had not been observed during previous pCT treatment courses. Therefore, hCT appears to be indicated for therapeutic use in patients who are resistant to foreign calcitonins.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LAdoi
10.1007/BF03348394subject
Has Abstractpub_date
1984-04-01 00:00:00pages
85-8issue
2eissn
0391-4097issn
1720-8386journal_volume
7pub_type
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journal_title:Journal of endocrinological investigation
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pub_type: 杂志文章,meta分析,评审
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更新日期:1990-09-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Journal of endocrinological investigation
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journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
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更新日期:1983-06-01 00:00:00
abstract::A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the ...
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