当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.

Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.

Abstract：

UNLABELLED:ABSTRACT. Several data show that meal intake and nutritional status regulate circulating ghrelin concentrations in humans. Ghrelin mainly circulates in two different forms: octanoyl and des-octanoyl ghrelin. Most circulating ghrelin is des-octanoyl ghrelin which is considered inactive because it lacks endocrine activity. However, recent evidence suggests that des-octanoyl ghrelin exerts biological activity such as stimulation of adipogenesis, cardiovascular effects and control of cell growth. In healthy humans, although the total ghrelin concentration is known to peak before meals and to be reduced by food intake, no data are available about the octanoyl ghrelin response in the absorptive state. Therefore, after an overnight fast, we compared the effects of a mixed meal ingestion (meal study) or of additional 240 min fasting (control study) on plasma concentrations of octanoyl and total ghrelin in 6 healthy subjects (body mass index: 23 +/- 0.7). At baseline, octanoyl-ghrelin accounted for 3.15 +/- 0.2% of total circulating ghrelin without differences between the two sessions. A similar ratio was maintained in the absorptive state with no differences between the studies and basal values. Compared with control, meal intake significantly suppressed (nadir at 90 min) octanoyl and total ghrelin by 38 +/- 3 and 40 +/- 3% of basal values, respectively. In the meal study, multivariate analysis of variance showed that serum insulin best predicted plasma octanoyl-ghrelin concentrations accounting for 97% of its variation (r2 = -0.97,p = 0.0016). IN CONCLUSION:in healthy humans, octanoyl-ghrelin represents about 3-4% of total circula-ting ghrelin and this ratio is closely maintained in post-absorptive and absorptive states.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Lucidi P,Murdolo G,Di Loreto C,Parlanti N,De Cicco A,Ranchelli A,Fatone C,Taglioni C,Fanelli C,Santeusanio F,De Feo P

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

RC12-5

issue

5

eissn

0391-4097

issn

1720-8386

pii

5336

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Mutations of LH and FSH receptors.

    abstract：:Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/BF03343777

    authors： Beck-Peccoz P,Romoli R,Persani L

    更新日期：2000-10-01 00:00:00

  • Association between bone mineral density and nonalcoholic fatty liver disease in Korean adults.

    abstract：PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is associated with various metabolic abnormalities that can increase the risk of an osteoporotic fracture. Across the few previous studies of the association between NAFLD and bone mineral density (BMD), the association was not consistent. We examined the association bet...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-016-0528-3

    authors： Lee SH,Yun JM,Kim SH,Seo YG,Min H,Chung E,Bae YS,Ryou IS,Cho B

    更新日期：2016-11-01 00:00:00

  • Partial recovery of adrenal function in a patient with autoimmune Addison's disease.

    abstract：OBJECTIVE:To our knowledge, no case of remission in autoimmune Addison's disease has previously been reported. We describe a patient with primary adrenal insufficiency caused by autoimmune adrenalitis in whom partial remission was observed after 7 yr. CASE:A 39-yr-old male was referred because of extreme fatigue, weig...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345623

    authors： Smans LC,Zelissen PM

    更新日期：2008-07-01 00:00:00

  • Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma.

    abstract：:Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic reso...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343674

    authors： Syro LV,Horvath E,Kovacs K

    更新日期：2000-01-01 00:00:00

  • Transoral thyroidectomy: a viable surgical option with unprecedented complications-a case series.

    abstract：PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-017-0808-6

    authors： Bakkar S,Al Hyari M,Naghawi M,Corsini C,Miccoli P

    更新日期：2018-07-01 00:00:00

  • Thyroid nodule recurrence following lobo-isthmectomy: incidence, patient's characteristics, and risk factors.

    abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0946-5

    authors： Zatelli MC,Lamartina L,Meringolo D,Arvat E,Damiani L,Grani G,Nervo A,Durante C,Giacomelli L

    更新日期：2018-12-01 00:00:00

  • Glucose-stimulated insulin secretion: Effects of high-fat diet and acute stress.

    abstract：BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8959

    authors： Ghalami J,Zardooz H,Rostamkhani F,Farrokhi B,Hedayati M

    更新日期：2013-11-01 00:00:00

  • There are no acute cardiac effects of a single iv dose of human ghrelin in severe growth hormone deficient patients.

    abstract：:It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocar...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03347499

    authors： Janssen JA,Poldermans D,Hofland LJ,Vourvouri EC,Muller AF,Bax JJ,Deghenghi R,Broglio F,Ghigo E,van der Lely AJ

    更新日期：2004-07-01 00:00:00

  • Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis.

    abstract：:Eighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03348925

    authors： Magini A,Pellegrini S,Tavella K,Forti G,Massi GB,Serio M

    更新日期：1993-11-01 00:00:00

  • Intracranial volume receptors: possible role on ADH homeostatic control.

    abstract：:Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349891

    authors： Satta A,Palomba D,Demontis MP,Varoni MV,Faedda R,Ginanni A,Anania V

    更新日期：1996-07-01 00:00:00

  • Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotypes.

    abstract：BACKGROUND:Serum DHEAS has been found to be elevated in some women with polycystic ovary syndrome (PCOS). We wished to determine whether this prevalence is different in women with androgen excess who have different phenotypes and to correlate these findings with various cardiovascular and metabolic parameters. METHODS...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347408

    authors： Carmina E,Lobo RA

    更新日期：2007-02-01 00:00:00

  • Incidence of congenital hypothyroidism in the Autonomous Province of Bolzano: benefit of increased iodine intake.

    abstract：PURPOSE:Although a nation-wide salt iodization program on voluntary basis was implemented in 2005, many areas in our country are still characterized by mild iodine deficiency. Differently from the rest of Italy, an efficient program of iodine prophylaxis was implemented in 1981 in the Autonomous Province of Bolzano. Th...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0206-2

    authors： Olivieri A,Radetti G,Medda E,Italian Study Group for Congenital Hypothyroidism.

    更新日期：2015-02-01 00:00:00

  • Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines.

    abstract：BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346542

    authors： Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

    更新日期：2010-01-01 00:00:00

  • GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution.

    abstract：PURPOSE:Growth hormone deficiency (GHD) is the most common endocrine late effect observed in childhood cancer survivors (CCS) previously submitted to cranial irradiation. Radiation therapy can also increase the risk of second neoplasms (SNs). Since in previous studies GH replacement therapy was associated with increase...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-014-0179-1

    authors： Brignardello E,Felicetti F,Castiglione A,Fortunati N,Matarazzo P,Biasin E,Sacerdote C,Ricardi U,Fagioli F,Corrias A,Arvat E

    更新日期：2015-02-01 00:00:00

  • Somatotropin adenoma and resistance to thyroid hormone.

    abstract：:Resistance to thyroid hormone (RTH) is a rare disease characterized by non-suppressed TSH in spite of high free thyroid hormone levels. Up to date, in the literature, there are more than 600 RTH cases, but co-incidental hypophyseal adenoma was reported in only 1 case. In the literature, despite reported cases with thy...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346468

    authors： Berker D,Aydin Y,Tutuncu YA,Isik S,Delibasi T,Berker M,Guler S,Kamel N

    更新日期：2009-03-01 00:00:00

  • Role of vitamin K on biochemical markers, bone mineral density, and fracture risk.

    abstract：:Osteoporosis is a multifactorial chronic disease that may become even more prevalent and more of a public health problem in the decades to come. Recent research has indicated that a number of macro- and micronutrients are involved in the development of bone health. In the past decade it became evident that vitamin K p...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Francucci CM,Rilli S,Fiscaletti P,Boscaro M

    更新日期：2007-01-01 00:00:00

  • Does a male polycystic ovarian syndrome equivalent exist?

    abstract：:The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of ea...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-017-0728-5

    authors： Cannarella R,Condorelli RA,Mongioì LM,La Vignera S,Calogero AE

    更新日期：2018-01-01 00:00:00

  • Sex-dependency of hepatic alcohol metabolizing enzymes.

    abstract：:In mature female rats the administration of testosterone led to a striking reduction of hepatic alcohol dehydrogenase activity, whereas the hepatic microsomal ethanol oxidizing system as well as catalase were both increased in activity under these experimental conditions. Conversely, estradiol left the activities of a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348330

    authors： Teschke R,Wiese B

    更新日期：1982-07-01 00:00:00

  • Mineralocorticoid receptor p.I180V polymorphism: association with body mass index and LDL-cholesterol levels.

    abstract：BACKGROUND/AIMS:Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular ris...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346627

    authors： Fernandes-Rosa FL,Bueno AC,de Souza RM,de Castro M,dos Santos JE,Foss MC,Zennaro MC,Bettiol H,Barbieri MA,Antonini SR

    更新日期：2010-07-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract：BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0875-3

    authors： Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期：2019-01-01 00:00:00

  • 5-HT2 receptors are partially involved in the relationship between renin release and delta relative power.

    abstract：:A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03349016

    authors： Brandenberger G,Luthringer R,Muller G,Gronfier C,Schaltenbrand N,Macher JP,Muzet A,Follenius M

    更新日期：1996-09-01 00:00:00

  • Association between emotional and behavioral problems and metabolic control in children and adolescents with Type 1 diabetes.

    abstract：OBJECTIVE:We aimed to investigate the differences in emotional and behavioral problems and to explore the association between the level of psychiatric problems and the metabolic control in Type 1 diabetes. METHODS:The children with Type 1 diabetes (no.=42) and the "healthy" control group (no.=42), their parents and en...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345721

    authors： Akbaş S,Karabekiroğlu K,Ozgen T,Tasdemir G,Karakurt M,Senses A,Böke O,Aydin M

    更新日期：2009-04-01 00:00:00

  • Prolactin response to growth hormone-releasing hormone during chronic thyrotropin-releasing hormone infusion in the treatment of amyotrophic lateral sclerosis.

    abstract：:In six patients suffering from amyotrophic lateral sclerosis we evaluated changes of T4, T3, TSH, PRL, and GH during treatment by continuous iv infusion of TRH for at least 15 days. No clinical improvement was detected. A significant rise of thyroid hormone levels was observed, as well as an upward trend of basal TSH ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349584

    authors： Chiodini PG,Attanasio R,Liuzzi A,Cozzi R,Orlandi P,De Palo C,Dallabonzana D,Girotti F,Testa D

    更新日期：1990-09-01 00:00:00

  • Effect of propranolol on aldosterone response to heat exposure in sodium-restricted men.

    abstract：:To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03349377

    authors： Brandenberger G,Follenius M,Oyono S

    更新日期：1980-10-01 00:00:00

  • Management of peritoneal hemorrhage due to follicle rupture under anticoagulation therapy.

    abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348998

    authors： Ulrich U,Rossmanith WG

    更新日期：1994-05-01 00:00:00

  • Resveratrol and its impact on aging and thyroid function.

    abstract：:Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and agi...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.3275/7926

    authors： Duntas LH

    更新日期：2011-11-01 00:00:00

  • The effect of splanchnic nerve stimulation on the uptake of atrial natriuretic peptide by the adrenal gland in conscious calves.

    abstract：:A technique has been developed with which it has been possible to quantify the output of a wide variety of agonists including catecholamines, glucocorticoids, mineralocorticoids, enkephalins and various peptides, from the adrenal gland in the conscious unrestrained calf; also to investigate responses to electrical sti...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349647

    authors： Edwards AV,Ghatei MA,Bloom SR

    更新日期：1990-12-01 00:00:00

  • Thyroid ultrasonography related to clinical and laboratory findings in patients with silent thyroiditis.

    abstract：:We summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from Graves' disease. Serum T3 and T4 were increased in all cases, and the ratio of T3/T4 (ng/micrograms) was ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348732

    authors： Miyakawa M,Tsushima T,Onoda N,Etoh M,Isozaki O,Arai M,Shizume K,Demura H

    更新日期：1992-04-01 00:00:00

  • A reappraisal of the role of methimazole and other factors on the efficacy and outcome of radioiodine therapy of Graves' hyperthyroidism.

    abstract：:The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348615

    authors： Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

    更新日期：1990-06-01 00:00:00

  • Monitoring testosterone replacement therapy with transdermal gel: when and how?

    abstract：PURPOSE:Testosterone replacement therapy (TRT) is recommended for the treatment of most cases of male hypogonadism. Transdermal testosterone (T) gels are commonly used in clinical practice; however, there is little evidence concerning how to monitor dosage to bring and maintain serum T levels in the normal physiologic ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01082-x

    authors： Sansone A,Sansone M,Selleri R,Schiavo A,Gianfrilli D,Pozza C,Zitzmann M,Lenzi A,Romanelli F

    更新日期：2019-12-01 00:00:00