当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity.

UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity.

Abstract：

BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A>G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated severely obese adults [61 females and 41 males, median body mass index (BMI) = 47.8 kg/m2] with NAFLD, with (MS+) or without MS (MS-) from Southern Italy. SUBJECT AND METHODS:The UCP1 polymorphism was tested by the TaqMan method, main biochemical parameters by routinary methods, adiponectin, and leptin serum levels by enzyme-linked immunosorbent assay. MS was diagnosed according to the American Heart Association criteria, liver steatosis was detected by ultrasound. RESULTS:MS was present in 53% male and 66% female obese patients. Only total cholesterol (p=0.04 males and p=0.002 females) and L/A ratio (p=0.03 males) differed between MS+ and MS- obese patients. At multivariate analysis, severe liver steatosis was significantly associated with: UCP1 (AG+GG) genotypes [odds ratio-confidence interval (OR-CI): 4.25; 1.12-16.13], MS (OR-CI: 8.47; 1.78-40.25), low adiponectin levels (OR-CI: 0.92; 0.87-0.98), high alanine aminotransferase levels (OR-CI: 1.03; 1.00-1.06), age (ORCI: 1.08; 1.00-1.15), and male gender (OR-CI: 10.78; 1.61- 71.96). CONCLUSION:In addition to traditional factors, total cholesterol and L/A ratio appear to contribute to MS characterization in severe obesity. Furthermore, the UCP1 (AG+GG) genotypes and low adiponectin levels could predispose to a more severe liver steatosis independently of MS presence. Based on our data, polymorphic UCP1 (AG+GG) obese patients with low adiponectin levels appear to be high-risk subjects for worsening of liver steatosis, a NAFLD, possibly requiring a second-step evaluation by liver biopsy.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Labruna G,Pasanisi F,Nardelli C,Tarantino G,Vitale DF,Bracale R,Finelli C,Genua MP,Contaldo F,Sacchetti L

doi

10.1007/BF03346500

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

525-9

issue

6

eissn

0391-4097

issn

1720-8386

pii

6108

journal_volume

32

pub_type

杂志文章

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Basal insulin supplementation in Type 1 diabetic children: a long-term comparative observational study between continuous subcutaneous insulin infusion and glargine insulin.

    abstract：:No long-term data are available on the efficacy of glargine insulin in comparison with continuous sc insulin infusion (CSII) in children and adolescents affected by Type 1 diabetes (T1D). Our aim was to compare the 2-yr efficacy of the 2 insulin approaches, in order to know how to best supply basal insulin in these pa...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346351

    authors： Schiaffini R,Patera PI,Bizzarri C,Ciampalini P,Cappa M

    更新日期：2007-07-01 00:00:00

  • 17beta-Hydroxysteroid dehydrogenase-3 deficiency: from pregnancy to adolescence.

    abstract：OBJECTIVE:Aim of this study is to report on basal clinical phenotype and follow up after diagnosis, of patients with 17beta-hydroxysteroid-dehydrogenase type 3 (17beta-HSD3) deficiency in Italy. SETTING:Pediatric Endocrine Departments, University Hospitals. PATIENTS:The cases of 5 Italian subjects affected by 17beta-...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345738

    authors： Bertelloni S,Balsamo A,Giordani L,Fischetto R,Russo G,Delvecchio M,Gennari M,Nicoletti A,Maggio MC,Concolino D,Cavallo L,Cicognani A,Chiumello G,Hiort O,Baroncelli GI,Faienza MF

    更新日期：2009-09-01 00:00:00

  • Occurrence of lymphocyte proliferative response to thyroglobulin and antithyroglobulin antibodies in normal individuals: lack of correlation with HLA.

    abstract：:Peripheral mononuclear cells (MNC) of patients with autoimmune thyroid disease have been shown to proliferate when cultured with human thyroglobulin (hTg). In addition, such a phenomenon is apparent in a certain number of healthy individuals. In this study we have attempted to correlate hTg-induced MNC proliferation, ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347192

    authors： Bagnasco M,Orlandini A,Melioli G,Venuti D,Canonica GW,Ferrara GB

    更新日期：1987-04-01 00:00:00

  • GH-IGF-I axis in non-obese women with functional hyperandrogenism.

    abstract：:The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding prote...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345102

    authors： Legan M,Kocijancic A,Prezelj J,Osredkar J,Fisker S

    更新日期：2002-09-01 00:00:00

  • Cardiovascular outcome trials and major cardiovascular events: does glucose matter? A systematic review with meta-analysis.

    abstract：PURPOSE:We did a meta-analysis with meta-regression to evaluate the relationship between hemoglobin A1c (A1C) reduction and the primary CV outcome of cardiovascular outcome trials (CVOTs). METHODS:We used a random effects meta-analysis of the 12 CVOTs to quantify the effect of A1C reduction on major cardiovascular eve...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,meta分析

    doi：10.1007/s40618-019-01047-0

    authors： Giugliano D,Chiodini P,Maiorino MI,Bellastella G,Esposito K

    更新日期：2019-10-01 00:00:00

  • Acromegaly: effects on bone metabolism and mass.

    abstract：:GH has a pivotal role in maintaining bone mass and metabolism both during childhood and in adult life. This effect depends on a complex interaction between circulating and peripherically produced GH and IGF-I. In vitro data and the use of genetically modified animals have greatly expanded the understanding of regulato...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Bogazzi F,Cosci C,Sardella C,Martino E,Gasperi M

    更新日期：2005-01-01 00:00:00

  • The effects of calcitonin on idiopathic nephrolithiasis. Evidence of bone involvement in fasting hypercalciuria.

    abstract：:This study was performed to evaluate the antihypercalciuric effect of calcitonin (CT), a potent inhibitor of bone osteoclastic activity, on idiopathic hypercalciuria (IH). Forty-two stone formers were studied: 18 suffered from fasting hypercalciuria (FH), 12 from nonfasting hypercalciuria (NFH) and 12 were normocalciu...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350171

    authors： Filipponi P,Mannarelli C,Gubbiotti G,Blass A,Moretti I,Tini S,Giuseppetti N,Ballanti S,Morucci P

    更新日期：1988-07-01 00:00:00

  • Slow growth of benign thyroid nodules after menopause: no need for long-term thyroxine suppressive therapy in post-menopausal women.

    abstract：:Benign thyroid nodules represent a very common disorder, the management of which is still controversial. The aim of the present work was to evaluate by ultrasound examination the volume changes of thyroid nodules in post-menopausal women presenting single palpable nodular goiter of recent onset (less than 6 months fro...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03350907

    authors： Costante G,Crocetti U,Schifino E,Ludovico O,Capula C,Nicotera M,Arturi F,Filetti S

    更新日期：2004-01-01 00:00:00

  • Growth hormone therapy in a poorly growing child with hypophosphatemic rickets.

    abstract：:We treated a 10 6/12 year old prepubertal male with hypophosphatemic rickets, who was growing poorly despite appropriate treatment with calcitriol and phosphate, with exogenous growth hormone (for an initial trial period of 4 months, followed by 14 months of continuous treatment at a dose of 4 IU three times weekly) e...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349633

    authors： Lanes R,Harrison HE

    更新日期：1990-11-01 00:00:00

  • A preliminary study: proteomic analysis of exosomes derived from thyroid-stimulating hormone-stimulated HepG2 cells.

    abstract：BACKGROUND:Thyroid-stimulating hormone (TSH) plays an important role in the regulation of lipid metabolism. However, little is known about the role that exosomes play in the process of TSH-induced lipotoxicity in non-alcoholic fatty liver disease (NAFLD). As a preliminary step, the present study set out to investigate ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-020-01210-y

    authors： Ma S,Shao S,Yang C,Yao Z,Gao L,Chen W

    更新日期：2020-09-01 00:00:00

  • Arterial erectile dysfunction: reliability of new markers of endothelial dysfunction.

    abstract：OBJECTIVE:Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. Aim of this study was to evaluate a new immunophenotype of EPC and EMP in patients with arterial erectile dysfunction (AED) compared to psychogenic erectile dysfunction (PED). MATERIALS...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346728

    authors： La Vignera S,Condorelli R,Vicari E,D'Agata R,Calogero AE

    更新日期：2011-11-01 00:00:00

  • Characterization of novel genes in AZF regions.

    abstract：:The long arm of the Y chromosome contains genes mapped in loci involved in male infertility, short stature and gonadoblastoma. However, many of these genes have not been fully characterized, and are not currently investigated in patients affected by such diseases. We report a study aimed to the genomic characterizatio...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343790

    authors： Stuppia L,Gatta V,Fogh I,Gaspari AR,Grande R,Morizio E,Fantasia D,Pizzuti A,Calabrese G,Palka G

    更新日期：2000-11-01 00:00:00

  • Effect of chronic endogenous hypercalcemia on prolactin and thyrotropin responsiveness in man.

    abstract：:To investigate whether chronic endogenous hypercalcemia influences TSH and/or PRL release from pituitary thyrotrophs and lactotrophs in man, 10 patients with endogenous hypercalcemia, due either to cancer or to primary hyperparathyroidism, were injected with 25 micrograms TRH iv. The TSH and PRL responses were compare...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349498

    authors： Röjdmark S,Edström E,Nordlund M

    更新日期：1984-12-01 00:00:00

  • Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.

    abstract：:The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF03348396

    authors： Loli P,Berselli ME,Frascatani F,Muratori F,Tagliaferri M

    更新日期：1984-04-01 00:00:00

  • The combined effect of adiposity, fat distribution and age on cardiovascular risk factors and motor disability in a cohort of obese women (aged 18-83).

    abstract：:Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349195

    authors： Lafortuna CL,Agosti F,Proietti M,Adorni F,Sartorio A

    更新日期：2006-11-01 00:00:00

  • CDY1 analysis in infertile patients with DAZ deletions.

    abstract：:The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility. However, other genes have been recently mapped to this region and they could contribute to the AZFc phenotype. In particular, the testis-specific CDY1 (chromadomain protein 1) ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343814

    authors： Ferlin A,Moro E,Rossi A,Foresta C

    更新日期：2001-02-01 00:00:00

  • Decrease of thyroid antibodies during pregnancy.

    abstract：:The behavior of serum anti-thyroglobulin (Abs-Tg) and antimicrosomal antibodies (Abs-Mc) was examined during and after normal pregnancies. The antibodies titer decreases as pregnancy progresses; they cross the placenta and are present in the fetal serum. Infants' thyroid function is not affected by this transplacentar...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349385

    authors： D'Armiento M,Salabé H,Vetrano G,Scucchia M,Pachi A

    更新日期：1980-10-01 00:00:00

  • Endocannabinoids and energy metabolism.

    abstract：:Although adjustments to nutritional lifestyle and increased physical activity remain the milestones of weight loss therapy, it is evident from the exponential increase of the number of obese subjects in Western countries that these two approaches alone are no longer able to limit this progression. This alarming phenom...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Pagotto U,Pasquali R

    更新日期：2006-01-01 00:00:00

  • A mathematical model in the analysis of the response to growth hormone treatment in pediatric patients with diagnosis of growth hormone deficiency.

    abstract：:In the literature, few studies analyze the effect of GH therapy on height, preferring a more indirect approach, where factors influencing the total pubertal and pre-pubertal growth in GH-deficient patients are evaluated and subsequently used to estimate the overall effect at the end of the therapy; unfortunately, this...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345420

    authors： Migliaretti G,Berchialla P,Borraccino A,Gregori D,Cavallo F,Commissione GH Piemonte.

    更新日期：2012-02-01 00:00:00

  • Plasma levels of luteinizing hormone, estradiol and androstenedione in sows with inadequate plasma progesterone.

    abstract：:The authors report the profiles of luteinizing hormone (LH), estradiol (E2), progesterone (P) and androstenedione (A) in some female pigs with altered plasma hormonal levels. Twenty cycles are described and 19 out of them are characterized by low plasma P in luteal phase of different etiology, at least as measured by ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350557

    authors： Pierantoni R,Genazzani AR,Perotti L,Enne G,Inaudi P,d'Istria M,Musarò MA,Citarella F,Fasano S,Delrio G

    更新日期：1983-02-01 00:00:00

  • Bone turnover is reduced in children with juvenile rheumatoid arthritis.

    abstract：:Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyv...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347283

    authors： Falcini F,Ermini M,Bagnoli F

    更新日期：1998-01-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract：BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-018-0875-3

    authors： Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期：2019-01-01 00:00:00

  • Copeptin in the differential diagnosis of hypotonic polyuria.

    abstract：COPEPTIN:Copeptin is secreted in equimolar amount to Arginine Vasopressin (AVP) but can easily be measured with a sandwich immunoassay. Both peptides, copeptin and AVP, show a high correlation. Accordingly, copeptin mirrors the amount of AVP in the circulation and its measurement provides an attractive marker in the di...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：10.1007/s40618-019-01087-6

    authors： Christ-Crain M,Fenske WK

    更新日期：2020-01-01 00:00:00

  • The role of growth hormone in glucocorticoid-induced osteoporosis.

    abstract：:Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. GC influence bone metabolism via a modulation of different components of the GH/IGF-I system. GH has multiple anabolic effects on bone, either direct or mediated by IGF-I. GH-deficient subjects have significant reduction in bo...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Lombardi G,Colarusso S,Di Somma C,Guerra E,Tauchmanova L,Colao A

    更新日期：2008-07-01 00:00:00

  • Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.

    abstract：:Thyrotropin binding characteristics and adenylate cyclase (AC) activity of thyroid plasma membranes were studied in 52 tissues from normal and diseased human thyroids. Data from normal glands, Graves' goiters, non toxic multinodular goiters and nodular and perinodular tissue of toxic nodular goiters show the same basa...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350977

    authors： Carayon P,Guibout M,Lissitzky S

    更新日期：1978-10-01 00:00:00

  • Diabetes insipidus with spontaneous remission.

    abstract：:Pathogenesis of idiopathic diabetes insipidus is unknown and the clinical course of the disease is permanent. However, we observed one patient who was diagnosed of idiopathic diabetes insipidus spontaneously reverted after approximately 13 months. The cause and pathogenesis of the disease were not evident. However, so...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350038

    authors： Ohshima K,Okada S,Onai T,Umahara M,Mori M,Kobayashi I,Kobayashi S,Katakai S

    更新日期：1989-11-01 00:00:00

  • Effects of starvation on pituitary and plasma growth hormone in rats.

    abstract：:The present experiments were undertaken to study the effect of complete food removal on body weight, pituitary growth hormone (GH), plasma GH and glucose concentration in male and female Wistar rats. Plasma and pituitary GH levels were measured by means of a specific radioimmunoassay. Plasma glucose concentration decr...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349417

    authors： Gonzalez C,Jolin T

    更新日期：1981-01-01 00:00:00

  • Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients.

    abstract：BACKGROUND:Increasing evidence showed that telomere length was shorter in age-related diseases, but the mechanism of this phenomenon is still unclear. AIM:To determine whether telomere shortening occurs in Type 1 diabetes (T1D) and Type 2 diabetes (T2D), and explore the effect of antioxidant status on the telomere len...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/9036

    authors： Ma D,Zhu W,Hu S,Yu X,Yang Y

    更新日期：2013-12-01 00:00:00

  • Four year treatment with a long acting somatostatin analogue in a patient with Verner-Morrison syndrome.

    abstract：:The case is described of a woman with a Verner-Morrison syndrome of extreme severity, caused by an occult VIPoma. Administration of SMS 201-995 (Sandoz) (SMS) at the dose of 150 and subsequently of 250 micrograms daily, decreased plasma levels of vasoactive intestinal polypeptide (VIP) from about 500 to 100 pg/ml (hig...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347894

    authors： Brunani A,Crespi C,De Martin M,Dubini A,Piolini M,Cavagnini F

    更新日期：1991-09-01 00:00:00

  • Follow-up evaluation of patients with Graves' disease treated by subtotal thyroidectomy and risk factor analysis for post-operative thyroid dysfunction.

    abstract：:Eight-year follow-up evaluation and analysis of factors related to postoperative thyroid dysfunction were made in 216 patients with Graves' disease treated by subtotal thyroidectomy. The postoperative status of thyroid function were as follows according to hypersensitive TSH level: 65 patients (30.1%) were euthyroid, ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344945

    authors： Sugino K,Mimura T,Toshima K,Iwabuchi H,Kitamura Y,Kawano M,Ozaki O,Ito K

    更新日期：1993-03-01 00:00:00