UCP1 -3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity.

Abstract:

BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A>G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated severely obese adults [61 females and 41 males, median body mass index (BMI) = 47.8 kg/m2] with NAFLD, with (MS+) or without MS (MS-) from Southern Italy. SUBJECT AND METHODS:The UCP1 polymorphism was tested by the TaqMan method, main biochemical parameters by routinary methods, adiponectin, and leptin serum levels by enzyme-linked immunosorbent assay. MS was diagnosed according to the American Heart Association criteria, liver steatosis was detected by ultrasound. RESULTS:MS was present in 53% male and 66% female obese patients. Only total cholesterol (p=0.04 males and p=0.002 females) and L/A ratio (p=0.03 males) differed between MS+ and MS- obese patients. At multivariate analysis, severe liver steatosis was significantly associated with: UCP1 (AG+GG) genotypes [odds ratio-confidence interval (OR-CI): 4.25; 1.12-16.13], MS (OR-CI: 8.47; 1.78-40.25), low adiponectin levels (OR-CI: 0.92; 0.87-0.98), high alanine aminotransferase levels (OR-CI: 1.03; 1.00-1.06), age (ORCI: 1.08; 1.00-1.15), and male gender (OR-CI: 10.78; 1.61- 71.96). CONCLUSION:In addition to traditional factors, total cholesterol and L/A ratio appear to contribute to MS characterization in severe obesity. Furthermore, the UCP1 (AG+GG) genotypes and low adiponectin levels could predispose to a more severe liver steatosis independently of MS presence. Based on our data, polymorphic UCP1 (AG+GG) obese patients with low adiponectin levels appear to be high-risk subjects for worsening of liver steatosis, a NAFLD, possibly requiring a second-step evaluation by liver biopsy.

journal_name

J Endocrinol Invest

authors

Labruna G,Pasanisi F,Nardelli C,Tarantino G,Vitale DF,Bracale R,Finelli C,Genua MP,Contaldo F,Sacchetti L

doi

10.1007/BF03346500

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

525-9

issue

6

eissn

0391-4097

issn

1720-8386

pii

6108

journal_volume

32

pub_type

杂志文章
  • Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein.

    abstract:BACKGROUND:Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to "endocrine disruptor" action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a cr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347061

    authors: Agretti P,Dimida A,De Marco G,Ferrarini E,Rodrìguez Gonzàlez JC,Santini F,Vitti P,Pinchera A,Tonacchera M

    更新日期:2011-03-01 00:00:00

  • Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways.

    abstract:BACKGROUND:While it is now accepted that genes and their products affect food intake, the concept that locomotor behavior or the propensity for physical activity is controlled by neuro hum oral regulators is frequently underappreciated. In mammals, complex interactions have developed to allow the cross-talk between fue...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0225-z

    authors: Ceccarini G,Maffei M,Vitti P,Santini F

    更新日期:2015-02-01 00:00:00

  • Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.

    abstract::We studied the effects of high doses of methimazole (MMI) or propylthiouracil (PTU) on thyroid-stimulating antibody (TSAb), antithyroid microsomal (MCHA) and antithyroglobulin (TGHA) levels in Graves' disease and Hashimoto's thyroiditis. Thirty Graves' hyperthyroid patients were treated for 14 +/- 8 months (mean +/- S...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348107

    authors: Romaldini JH,Werner MC,Rodrigues HF,Teixeira VL,Werner RS,Farah CS,Bromberg N

    更新日期:1986-06-01 00:00:00

  • Impact of overweight and obesity on obstetric outcomes.

    abstract::Abnormal nutritional status is an increasingly common complication in developed countries and, as reproductive age women are a part of this trend, the effect of maternal obesity on the pregnancy and neonate must be investigated. Pregestational obesity or overweight condition or an excessive gestational weight gain can...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0058-9

    authors: Triunfo S,Lanzone A

    更新日期:2014-04-01 00:00:00

  • Diet influences the content of bioactive peptides in goat milk.

    abstract::Leptin, insulin, ghrelin, and IGF-I are circulating peptide hormones concerned with energy homeostasis and the regulation of GH axis. They are present in human milk, and are thought to promote neonatal development. The aim of the present study was to detect these substances in goat milk and determine whether their lev...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346493

    authors: Rosi F,Aufy AA,Magistrelli D

    更新日期:2009-06-01 00:00:00

  • The vitamin D receptor fokI start codon polymorphism and bone mineral density in male hypogonadotrophic hypogonadism.

    abstract::The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347571

    authors: Bolu SE,Orkunoglu Suer FE,Deniz F,Uckaya G,Imirzalioglu N,Kutlu M

    更新日期:2005-10-01 00:00:00

  • Study of the family of a patient with male-limited precocious puberty (MPP) due to T1193C transition in exon 11 of LH receptor gene.

    abstract::Molecular diagnostics of the LHR gene was conducted in a 5-year-old boy with clinical symptoms and hormonal profile typical of precocious puberty. His parents and 4 sisters were also diagnosed. Single-strand conformation polymorphism analysis under temperature gradient conditions (Multitemperature SSCP) of 3 overlappi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344001

    authors: Ignacak M,Starzyk J,Dziatkowiak H,Trzeciak WH

    更新日期:2002-03-01 00:00:00

  • The modulation of glucocorticoid receptor content by 3-O-methyl-D-glucose transport in human mononuclear leukocyte in obesity.

    abstract::Glucocorticoid receptors (GR) and 3-O-methyl-D glucose (3-O-MG) transport were determined in mononuclear leukocytes (MNL) from 11 abdominal obese subjects, 10 pituitary-dependent Cushing's syndrome (Cushing's disease) and 10 healthy controls. Using a whole-cell competitive binding assay and 3H-dexamethasone as tracer,...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350794

    authors: Güven M,Hatemi H,Taşan E,Altuntaş Y,Ulutin T,Tezcan V,Kanigür-Sultuybek G

    更新日期:1998-11-01 00:00:00

  • Vitamin D levels in a paediatric population of normal weight and obese subjects.

    abstract:BACKGROUND:Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. AIM:Aim of our study was to evaluate vitamin D status in children living in Northern Italy. METHODS:We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal an...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0108-3

    authors: Bellone S,Esposito S,Giglione E,Genoni G,Fiorito C,Petri A,Bona G,Prodam F

    更新日期:2014-09-01 00:00:00

  • Prevalence of hypopituitarism in patients with cerebrovascular diseases.

    abstract::Stroke is one of the main causes of death and disability in the adult population. Changes in pituitary hormone secretion may be observed during the acute phase of stroke, representing part of the adaptive response to injury. However, reduced pituitary hormone secretion, caused by pituitary and/or hypothalamus damage, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Bondanelli M,Ambrosio MR,Zatelli MC,Basaglia N,Degli Uberti EC

    更新日期:2008-09-01 00:00:00

  • Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance.

    abstract:BACKGROUND:Non-exercise activity thermogenesis has recently drawn attention because of its potential to prevent weight gain. AIM:This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance (IR) in the Japanese population....

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/9066

    authors: Uemura H,Katsuura-Kamano S,Yamaguchi M,Nakamoto M,Hiyoshi M,Arisawa K

    更新日期:2013-12-01 00:00:00

  • Glucose metabolism during ghrelin infusion in patients with anorexia nervosa.

    abstract::Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350816

    authors: Miljic D,Djurovic M,Pekic S,Doknic M,Stojanovic M,Milic N,Casanueva FF,Ghatei M,Popovic V

    更新日期:2007-10-01 00:00:00

  • Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones.

    abstract::Several in vivo experimental and clinical studies suggest that the production of thymic hormones, such as thymulin (Zn-FTS), is modulated by thyroid hormones. It was not determined in these studies, however whether such modulation is exerted directly on the thymic epithelial cells which synthesize and secrete thymic h...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349524

    authors: Mocchegiani E,Amadio L,Fabris N

    更新日期:1990-02-01 00:00:00

  • Apparent mineralocorticoid excess syndromes.

    abstract::Apparent mineralocorticoid excess (AME) is a syndrome attributable to congenital deficiency of the enzyme 11 beta-dehydrogenase (11 beta-OHSD) which converts active glucocorticoid cortisol to inactive cortisone. When 11 beta-OHSD activity is impaired, cortisol acts as a potent mineralocorticoid and causes hypertension...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03349763

    authors: Shimojo M,Stewart PM

    更新日期:1995-07-01 00:00:00

  • Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.

    abstract:UNLABELLED:ABSTRACT. Several data show that meal intake and nutritional status regulate circulating ghrelin concentrations in humans. Ghrelin mainly circulates in two different forms: octanoyl and des-octanoyl ghrelin. Most circulating ghrelin is des-octanoyl ghrelin which is considered inactive because it lacks endocr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:

    authors: Lucidi P,Murdolo G,Di Loreto C,Parlanti N,De Cicco A,Ranchelli A,Fatone C,Taglioni C,Fanelli C,Santeusanio F,De Feo P

    更新日期:2004-05-01 00:00:00

  • Correction to: Radioiodine ablation with 1,850 MBq in association with rhTSH in patients with differentiated thyroid cancer.

    abstract::Unfortunately, the fourth author's middle name was missed out in the original publication of this article. The complete correct name should read as follows. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s40618-018-0883-3

    authors: Tresoldi AS,Sburlati LF,Rodari M,Schinkelshoek MS,Perrino M,De Leo S,Montefusco L,Colombo P,Arosio M,Lania AGA,Fugazzola L,Chiti A

    更新日期:2018-08-01 00:00:00

  • Comparison of osteoprotegerin and vascular endothelial growth factor in normoalbuminuric Type 1 diabetic and control subjects.

    abstract:BACKGROUND:The aim of the current study was to evaluate the association of osteoprotegerin and vascular endothelial growth factor (VEGF) with glycemic indices and diabetes status. METHODS:A total of 44 normoalbuminuric Type 1 diabetic patients and 44 healthy control subjects, matched for age, body mass index, sex rati...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347110

    authors: Esteghamati A,Arefzadeh A,Zandieh A,Salehi Sadaghiani M,Noshad S,Nakhjavani M

    更新日期:2013-07-01 00:00:00

  • Catecholaminergic interactions in the regulation of thyrotropin (TSH) secretion in man.

    abstract::The TSH responses to the catecholamine depleting agent monoiodotyrosine (1 g po) and the dopamine receptor blocking drug metoclopramide (10 mg po) have been compared in euthyroid and hypothyroid subjects. Both drugs lead to a prompt and significant rise in TSH levels (peak values at 60-75 min) which is very much great...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348238

    authors: Scanlon MF,Rodriguez-Arnao MD,Pourmand M,Shale DJ,Weightman DR,Lewis M,Hall R

    更新日期:1980-04-01 00:00:00

  • Chronobiology of catecholamine excretion in normal and diabetic men.

    abstract::The adrenomedullary response to stimuli is often elevated in poorly controlled insulin dependent diabetic patients, and it is controversial whether the adrenomedullary hyperactivity induces the suppression of the circadian rhythm of catecholamines. We have studied the urinary excretion of catecholamines in 11 diabetic...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348628

    authors: Del Rio G,Carani C,Baldini A,Marrama P,Della Casa L

    更新日期:1990-07-01 00:00:00

  • Spying on organelle Ca²⁺ in living cells: the mitochondrial point of view.

    abstract::Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper under...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0178-2

    authors: Pendin D,Greotti E,Filadi R,Pozzan T

    更新日期:2015-01-01 00:00:00

  • Update on a new controversy in endocrinology: isolated maternal hypothyroxinemia.

    abstract::Isolated hypothyroxinemia (IH) is defined as a thyroxine level in the lower 5th (severe IH) or 10th percentile (mild IH) of the pregnancy-related reference range and a normal TSH. The etiology of IH remains unknown. This review aims to evaluate the biochemical criteria used to define IH in different published studies ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0203-5

    authors: Furnica RM,Lazarus JH,Gruson D,Daumerie C

    更新日期:2015-02-01 00:00:00

  • Testosterone, level of the lesion and age are independently associated with prostate volume in men with chronic spinal cord injury.

    abstract:PURPOSE:Although men with spinal cord injury (SCI) exhibit a prostate volume significantly smaller compared to age-matched able-bodied men, the independent association of lower prostate volume with its putative determinants has never been analyzed in this population. This study was designed to identify variables indepe...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01243-3

    authors: D'Andrea S,Castellini C,Minaldi E,Totaro M,Felzani G,Francavilla S,Francavilla F,Barbonetti A

    更新日期:2020-11-01 00:00:00

  • Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy.

    abstract:BACKGROUND:Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic c...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345575

    authors: Li JH,Zhang N,Wang JA

    更新日期:2008-02-01 00:00:00

  • Repeated transient hypergonadotropic amenorrhea during pharmacologic induction of multiple follicular development with exogenous gonadotropins.

    abstract::Human gonadotropins are widely used for induction of ovulation in the treatment of anovulatory infertility and for induction of multiple follicular development (MFD) in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and artificial insemination with husband's semen (AIH) programs. Reported is a pa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349615

    authors: Mais V,Melis GB,Antinori D,Paoletti AM,Strigini F,Guerriero S,de Ruggiero A,Fioretti P

    更新日期:1990-10-01 00:00:00

  • Prevalence of overweight/obesity, abdominal obesity and metabolic syndrome and atypical cardiometabolic phenotypes in the adult Romanian population: PREDATORR study.

    abstract:PURPOSE:The objectives were to assess the prevalence of overweight/obesity, abdominal obesity and metabolic syndrome (MetS), and to evaluate the characteristics of the metabolically unhealthy lean (MUHL) and metabolically healthy overweight/obese (MHO) phenotypes in a Romanian population-based sample from the PREDATORR...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-016-0470-4

    authors: Popa S,Moţa M,Popa A,Moţa E,Serafinceanu C,Guja C,Catrinoiu D,Hâncu N,Lichiardopol R,Bala C,Popa A,Roman G,Radulian G,Timar R,Mihai B

    更新日期:2016-09-01 00:00:00

  • Weight loss and sex steroid metabolism in massively obese man.

    abstract::To evaluate the effect of weight loss and diet therapy on plasma sex hormone behavior in male obesity, 9 men with a BMI of 43.4 +/- 6.3 participated in an 8-week semistarvation program [whose energy content ranged from 320 to 500 k calorie/day (proteins 44 to 60 g and carbohydrates 54 to 81 g per day)] followed by a t...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350136

    authors: Pasquali R,Casimirri F,Melchionda N,Fabbri R,Capelli M,Platè L,Patrono D,Balestra V,Barbara L

    更新日期:1988-03-01 00:00:00

  • Prevalence of metabolic syndrome in rural and urban Chinese population in Qingdao.

    abstract:AIMS:To investigate the prevalence of metabolic syndrome and its components in both rural and urban Chinese population. SUBJECTS AND METHODS:A population-based crosssectional survey was conducted in Qingdao, China in 2006 with 6100 Chinese aged 35-74 yr invited and 5355 who attended; 3357 subjects, 1562 urban (46.5%) ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF03346711

    authors: Zhao J,Pang ZC,Zhang L,Gao WG,Wang SJ,Ning F,Nan HR,Ren J,Qiao Q,Qingdao 2006 Diabetes Survey Group.

    更新日期:2011-06-01 00:00:00

  • Copeptin and insulin resistance: effect modification by age and 11 β-HSD2 activity in a population-based study.

    abstract:PURPOSE:Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0807-7

    authors: Canivell S,Mohaupt M,Ackermann D,Pruijm M,Guessous I,Ehret G,Escher G,Pechère-Bertschi A,Vogt B,Devuyst O,Burnier M,Martin PY,Ponte B,Bochud M

    更新日期:2018-07-01 00:00:00

  • A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear triiodothyronine receptors.

    abstract::A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; ho...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349636

    authors: Jaffiol C,Baldet L,Torresani J,Bismuth J,Papachristou C

    更新日期:1990-11-01 00:00:00

  • Maternal nutrition, fetal weight, body composition and disease in later life.

    abstract::Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345248

    authors: Zadik Z

    更新日期:2003-09-01 00:00:00