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New insights into vitamin D regulation: is there a role for alkaline phosphatase?

Abstract：

PURPOSE:The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity. To check what factors could interfere with the activity of vitamin D-25-hydroxylase and thus alter the 25-OHD concentrations, we looked for potential correlations between 25-OHD and results of liver function tests in healthy adults. METHODS:This single-centre study was retrospective and consisted of evaluating the correlations between 25-OHD and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bone alkaline phosphatase (BALP) in 349 healthy subjects aged from 18 to 65 years. In particular, in Group 1 (n = 119), we looked for correlations between 25OHD and all liver function tests and in Group 2 (n = 230) the correlation between 25OHD and BALP. RESULTS:In Group 1, we found no correlation between 25OHD and AST (r =  - 0.03; p = 0.8), ALT (r =  - 0.02; p = 0.91), GGT (r =  - 0.08; p = 0.68), direct bilirubin (r =  - 0.02; p = 0.89), indirect bilirubin (r =  - 0.24; p = 0.21), and total bilirubin (r =  - 0.24; p = 0.21) but one between 25OHD and ALP (r =  - 0.2; p = 0.007); in Group 2, we found a significant negative correlation between 25-OHD and BALP (r =  - 0.2; p = 0.0008). CONCLUSIONS:The correlations that we found suggest that ALP and BALP might be involved in the regulation of vitamin D-25-hydroxylase activity, but further studies are mandatory to confirm our assumptions.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Bellastella G,Scappaticcio L,Longo M,Carotenuto R,Carbone C,Caruso P,Maio A,Paglionico VA,Vietri MT,Maiorino MI,Esposito K

doi

10.1007/s40618-021-01503-w

subject

Has Abstract

pub_date

2021-01-25 00:00:00

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-021-01503-w

pub_type

杂志文章

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