Pro-gamma-MSH levels in various disorders of pituitary-adrenal axis.

Abstract:

:N-Terminal (1-76) portion of proopiomelanocortin (hNT) was measured in normals, Addison's, Nelson's, Cushing's disease, and in dexamethasone suppressible hyperaldosteronism (DSH) by using a specific homologous RIA. Mean basal immunoreactive hNT level was 94.2 +/- 6 pg/ml (mean +/- SE) in normal subjects. In Cushing's disease hNT values were slightly but not significantly (121 +/- 26.5 pg/ml) higher. In patients with DSH the levels were within normal range while they were much higher in Addison's and Nelson's syndromes. A strong correlation was found between IR-hNT and ACTH in plasma of normal subjects and patients with different disorders of the pituitary-adrenal axis (r = 0.83, p less than 0.01). Corticotropin-Releasing-Hormone (CRH) test in Cushing's disease stimulated the release of both ACTH and IR-hNT, showing a slightly different pattern of secretion. Similar patterns of secretion were found for hNT and ACTH in various pituitary-adrenal abnormalities. Normal levels of hNT in DSH do not support a role of this peptide in the pathogenesis of the disorder. Measurement of hNT in plasma can provide an additional tool for the diagnosis of patients with various disorders of the hypothalamic-pituitary-adrenal axis.

journal_name

J Endocrinol Invest

authors

Boscaro M,Giacomazzi P,Sonino N,Fallo F,Girard F,Bertagna X,Mantero F

doi

10.1007/BF03348575

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

29-33

issue

1

eissn

0391-4097

issn

1720-8386

journal_volume

13

pub_type

杂志文章
  • Prospective, systematically recorded mycophenolate safety data in Graves' orbitopathy.

    abstract:CONTEXT:The antiproliferative mechanism of mycophenolate acid (MPA) suggests a beneficial effect in patients with Graves' orbitopathy (GO). OBJECTIVE:To systematically analyze for the first time adverse events (AEs) during MPA treatment in GO. DESIGN:Prospective longitudinal study. SETTING:Academic tertiary referral...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-016-0441-9

    authors: Riedl M,Kuhn A,Krämer I,Kolbe E,Kahaly GJ

    更新日期:2016-06-01 00:00:00

  • Thyrotropin binding specificity for the thyrotropin receptor.

    abstract::Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor. We, therefore, re-evalu...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347814

    authors: Nagayama Y,Yamasaki H,Takeshita A,Kimura H,Ashizawa K,Yokoyama N,Yamashita S,Rapoport B,Nagataki S

    更新日期:1995-04-01 00:00:00

  • Intake of seaweed as part of a single sushi meal, iodine excretion and thyroid function in euthyroid subjects: a randomized dinner study.

    abstract:OBJECTIVE:Globalisation has extended to the kitchen and the Asian cuisine has gained international popularity with sushi and seaweed now being widespread. We explored the possible acute adverse effects of an iodine load from a single sushi-and-seaweed meal as seaweed iodine may induce thyroid dysfunction. METHODS:Nine...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40618-019-01122-6

    authors: Noahsen P,Kleist I,Larsen HM,Andersen S

    更新日期:2020-04-01 00:00:00

  • The IGF-I/IGFBP-3 system in gingival crevicular fluid and dependence on application of fixed force.

    abstract:BACKGROUND:During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345340

    authors: Toia M,Galazzo R,Maioli C,Granata R,Scarlatti F

    更新日期:2005-12-01 00:00:00

  • Partially compensated hypoadrenalism presenting with persistent skin pigmentation.

    abstract::A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349957

    authors: Whitehead EM,Atkinson AB,Hadden DR,Weaver J,Sheridan B

    更新日期:1989-03-01 00:00:00

  • Multiple intracranial recurrent tumors with hyperprolactinemia combined with a parasellar malignant fibrous histiocytoma long after transfrontal surgery and irradiation to a pituitary adenoma.

    abstract::We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadeno...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03351046

    authors: Fujikawa M,Okamura K,Sato K,Shiratsuchi M,Yao T,Mizokami T,Fujishima M

    更新日期:2001-06-01 00:00:00

  • Safety and effectiveness of Omnitrope® in patients with growth hormone deficiency: snapshot analysis of PATRO Adults study in the Italian population.

    abstract:PURPOSE:PATRO adults is an ongoing, multicenter, observational, post-marketing surveillance study aimed at investigating the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the recombinant human growth hormone (rhGH) Omnitrope® during routine clinical practice. This report describes data f...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01308-3

    authors: Arosio M,Arnaldi G,Gasco V,Giavoli C,Puxeddu E,Vettor R,Ambrosio MR,Gallinari P,Zouater H,Fedeli P,Ferone D

    更新日期:2021-02-01 00:00:00

  • Doppler echocardiographic patterns in patients with acromegaly.

    abstract::Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349779

    authors: Terzolo M,Avonto L,Matrella C,Pozzi R,Luceri S,Borretta G,Pecchio F,Ugliengo G,Magro GP,Reimondo G

    更新日期:1995-09-01 00:00:00

  • A new predictive equation for evaluating women body fat percentage and obesity-related cardiovascular disease risk.

    abstract:BACKGROUND:Obesity represents a global public health problem due to its association with cardiovascular diseases and reduced lifespan. The most widely used classification of obesity is expressed as Body Mass Index (BMI); however, this formula is an imprecise adiposity measurement that ignores several important factors ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-013-0048-3

    authors: De Lorenzo A,Nardi A,Iacopino L,Domino E,Murdolo G,Gavrila C,Minella D,Scapagnini G,Di Renzo L

    更新日期:2014-06-01 00:00:00

  • Dynamic investigation for evaluation of calcium metabolism and parathyroid function.

    abstract::Differently from other metabolic conditions, most of calcium metabolism disorders are diagnosed through simple detection of both serum and urinary excretion (24-h urine collection), levels of calcium, total and ionized form, and phosphate, and of calciotropic hormone serum levels, such as calcitonin, PTH and vitamin D...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Cioppi F,Falchetti A,Masi L,Brandi ML

    更新日期:2003-01-01 00:00:00

  • Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features.

    abstract::Pituitary adenomas are common neoplasms requiring medical and/or surgical treatment when associated with hormonal hypersecretion. Treatment of non-functioning pituitary adenomas is necessary when symptoms of mass effect or hormonal deficits occur. However, therapeutic options, including surgical resection and/or radio...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347449

    authors: Ballian N,Chrisoulidou A,Nomikos P,Samara C,Kontogeorgos G,Kaltsas GA

    更新日期:2007-09-01 00:00:00

  • Some considerations about evolution of idiopathic primary aldosteronism.

    abstract::The prevalence of primary aldosteronism has increased since many patients who were previously considered as being affected by low renin essential hypertension are actually satisfying the new diagnostic criteria using plasma aldosterone/ plasma renin activity (PRA) ratio. Many of these cases could be classified as subc...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346520

    authors: Armanini D,Fiore C

    更新日期:2009-07-01 00:00:00

  • A mathematical model in the analysis of the response to growth hormone treatment in pediatric patients with diagnosis of growth hormone deficiency.

    abstract::In the literature, few studies analyze the effect of GH therapy on height, preferring a more indirect approach, where factors influencing the total pubertal and pre-pubertal growth in GH-deficient patients are evaluated and subsequently used to estimate the overall effect at the end of the therapy; unfortunately, this...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345420

    authors: Migliaretti G,Berchialla P,Borraccino A,Gregori D,Cavallo F,Commissione GH Piemonte.

    更新日期:2012-02-01 00:00:00

  • Metabolic and cardiovascular profile in patients with Addison's disease under conventional glucocorticoid replacement.

    abstract:OBJECTIVE:Although two studies have shown that Addison's disease (AD) is still a potentially lethal condition for cardiovascular, malignant, and infectious diseases, a recent retrospective study showed a normal overall mortality rate. Differently from secondary hypoadrenalism, scanty data exist on the role of conventio...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345773

    authors: Giordano R,Marzotti S,Balbo M,Romagnoli S,Marinazzo E,Berardelli R,Migliaretti G,Benso A,Falorni A,Ghigo E,Arvat E

    更新日期:2009-12-01 00:00:00

  • An exception to the rule: ectopic ACTH production from functional neuroendocrine tissue in an ovarian dermoid cyst.

    abstract::Ectopic ACTH production accounts for 15% of Cushing's syndrome presentations and is characterized by the presence of an excess of ACTH precursors. However in the case presented here ectopic ACTH production was from functional pituitary tissue within an ovarian dermoid cyst. Endocrine investigations showed that the pro...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343930

    authors: Watson J,Taylor M,Pampiglione J,Rasbridge S,Armitage M

    更新日期:2001-11-01 00:00:00

  • Structure-function correlations of growth hormone or/and prolactin-producing pituitary adenomas: an in vitro study with the reverse hemolytic plaque assay.

    abstract::The purpose of this study was to detect in vitro growth hormone (GH) and prolactin (PRL) secretion from adenomas clinically associated with GH or PRL hypersecretion. The reverse hemolytic plaque assay (RHPA) was applied in order to reveal possible differences among various morphologic adenoma types, and to examine the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343628

    authors: Thodou E,Kontogeorgos G,Kyrodimou E,Salla H,Ramyar L,Vamvassakis E,Piaditis G,Anagnostopoulos N,Tzanis S,Levedis A,Rologis D,Asa SL

    更新日期:1999-10-01 00:00:00

  • A new test for the diagnosis of growth hormone deficiency due to primary pituitary impairment: combined administration of pyridostigmine and growth hormone-releasing hormone.

    abstract::The diagnosis of growth hormone (GH) deficiency (GHD) is currently based on failure to increase plasma GH levels to an arbitrary cutoff point of 7 or 10 micrograms/l in response to two provocative stimuli. False negative responses to these tests, however, frequently occur thus reducing their diagnostic reliability. Th...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349569

    authors: Ghigo E,Imperiale E,Boffano GM,Mazza E,Bellone J,Arvat E,Procopio M,Goffi S,Barreca A,Chiabotto P

    更新日期:1990-04-01 00:00:00

  • Sustainability of a well-monitored salt iodization program in Iran: marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt.

    abstract:OBJECTIVE:Two yr after legislation of salt iodization of 40 parts per million (ppm) in 1994, goiter was still endemic and urinary iodine concentration (UIC) remained elevated in many provinces of Iran. Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian ho...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346386

    authors: Azizi F,Mehran L,Sheikholeslam R,Ordookhani A,Naghavi M,Hedayati M,Padyab M,Mirmiran P

    更新日期:2008-05-01 00:00:00

  • Hyperprolactinemia affects spermiogenesis in adult male rats.

    abstract::The mechanisms underlying the antifertility effects of hyperprolactinemia have yet to be established in an appropriate experimental model. Hyperprolactinemia is a known side effect of fluphenazine, a broad spectrum, long-acting phenothiazine known to be dopamine type-D2 receptor antagonist. In our earlier study in adu...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345528

    authors: Aleem M,Choudhari J,Padwal V,Balasinor N,Parte P,Gill-Sharma MK

    更新日期:2005-01-01 00:00:00

  • Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones.

    abstract::Several in vivo experimental and clinical studies suggest that the production of thymic hormones, such as thymulin (Zn-FTS), is modulated by thyroid hormones. It was not determined in these studies, however whether such modulation is exerted directly on the thymic epithelial cells which synthesize and secrete thymic h...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349524

    authors: Mocchegiani E,Amadio L,Fabris N

    更新日期:1990-02-01 00:00:00

  • An in vitro procedure for the estimation of thyroid hormone releasing factors in sera of thyrotoxic patients.

    abstract::LATS containing sera and a number of Graves' disease sera stimulated T4 release from mouse thyroids in vitro as determined by RIA, thus confirming the presence of a thyroid hormone releasing factor in sera of thyrotoxic patients. The pattern of stimulation was similar to that previously shown for TSH in terms of T4 re...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350973

    authors: Maayan ML,Volpert EM,Dawry FP

    更新日期:1978-10-01 00:00:00

  • Effects of sex steroids on expression of adenylyl cyclase messenger RNA in rat uterus.

    abstract::The aim of our study was to investigate the effects of estradiol (E2) and/or progesterone (P4) bilateral ovariectomized rats on gene expressions of adenylyl cyclases (AC2, AC4, AC6, AC9). Non-pregnant (NP) Wister rats (between post-natal 10 and 12 weeks) and normal pregnant rats (between postnatal 10 and 14 weeks) wer...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347203

    authors: Asano K,Okawa T,Matsuoka I,Suzuki Y,Sato A

    更新日期:2005-04-01 00:00:00

  • Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome.

    abstract:OBJECTIVE:Neuroendocrine dysfunction in polycystic ovary syndrome (PCOS) was addressed by studying the steroid hormone changes in women with PCOS with either high or normal LH levels leading to inferences regarding the primacy of elevated LH in the pathophysiology of PCOS. METHODS:A cross-sectional study was designed ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345319

    authors: Doi SA,Al-Zaid M,Towers PA,Scott CJ,Al-Shoumer KA

    更新日期:2005-11-01 00:00:00

  • Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide.

    abstract::The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data we...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343991

    authors: Costante G,Grasso L,Schifino E,Marasco MF,Crocetti U,Capula C,Chiarella R,Ludovico O,Nocera M,Parlato G,Filetti S

    更新日期:2002-03-01 00:00:00

  • Prognostic value of serial serum thyroglobulin determinations after total thyroidectomy for differentiated thyroid cancer.

    abstract::Serial weekly serum samples (for 3 weeks) were obtained from 42 patients with differentiated thyroid cancer (DTC, papillary no.=35, follicular no.=6, Hurthle cell no.=1) for serum thyroid hormone, TSH and TG before and after total thyroidectomy. Serum specimens were also obtained one month after radioiodine (131I) the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343973

    authors: Lima N,Cavaliere H,Tomimori E,Knobel M,Medeiros-Neto G

    更新日期:2002-02-01 00:00:00

  • Mutations in the CYP21 B gene in a Chilean population with simple virilizing congenital adrenal hyperplasia.

    abstract::Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343746

    authors: Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

    更新日期:2000-06-01 00:00:00

  • Response of Paget's disease to human calcitonin in patients resistant to porcine calcitonin.

    abstract::Eleven patients with Paget's disease of bone, treated intermittently for 2-4 years with porcine calcitonin (pCT) and clinically resistant to pCT [no modifications of serum alkaline phosphatase (ALP) and urinary hydroxyproline ( uHOP ) during pCT administration] were treated with 0.5-0.25 mg/day of human calcitonin (hC...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348394

    authors: Lo Cascio V,Adami S,Galvanini G,Lazzaretto R,Ferrari M,Tartarotti D,Scuro LA

    更新日期:1984-04-01 00:00:00

  • Does SMS 201-995 normalize growth hormone secretion in acromegaly? GH day profiles and GH concentrations after oral glucose loading.

    abstract::GH secretion in acromegaly was studied in 8 patients before and during treatment with SMS 201-995, a somatostatin analogue, 100 micrograms twice daily, by evaluating GH day profiles and GH suppressibility after oral glucose tolerance tests (OGTT). Normalization of GH secretion, estimated by OGTT, was only observed in ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350758

    authors: van Liessum PA,Pieters GF,Smals AG,Swinkels LM,Benraad TJ,Kloppenborg PW

    更新日期:1989-09-01 00:00:00

  • Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.

    abstract::The effect of an oral dose of 200 or 400 mg sodium valproate (DPA) on ACTH and cortisol secretion was assessed in 11 patients with Cushing's disease (3 bilaterally adrenalectomized), 3 patients with Nelson's syndrome and 6 patients with Addison's disease. In none of the patients examined DPA induced changes in ACTH (a...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03348396

    authors: Loli P,Berselli ME,Frascatani F,Muratori F,Tagliaferri M

    更新日期:1984-04-01 00:00:00

  • The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP).

    abstract::Puberty is a major developmental stage. Damaging mutations, considered as "mistakes of nature", have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic-pituitary-gonadal (HPG) axis development, in the normosmic idiopathic hypogonado...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-017-0627-9

    authors: Leka-Emiri S,Chrousos GP,Kanaka-Gantenbein C

    更新日期:2017-08-01 00:00:00