Adverse effects of media reports on the treatment of osteoporosis.

Abstract:

PURPOSE:The review focused on the role that media reporting plays in the level of public awareness about osteoporosis and its influence on osteoporosis treatment decisions. METHODS:We reviewed the literature on the role of media on three main aspects influencing patient adherence to osteoporosis treatment: the awareness of osteoporosis as a major health problem, the perception of the effectiveness of osteoporosis medications, and the fear of adverse effects with osteoporosis medications. RESULTS:A review of the literature confirmed what is routinely observed in clinical practice-that media report can strongly influence the level of awareness of osteoporosis and fracture risk. Inadequate and/or incorrect information on osteoporosis in the media are associated with a low level of awareness of the disease. High-risk patients may have a poor understanding of the need for treatment. Alarming information in the media over the last 2 decades regarding effectiveness and safety of long-term osteoporosis treatment is associated with reduction in the use of osteoporosis medications. CONCLUSIONS:There is a gap between the application of clinical recommendations and patient perceptions of osteoporosis and its treatment. There is a need for better education of patients and practitioners aimed at recognizing the serious consequences of fractures and understanding the expected benefits and potential risks of treatment. Media reports that disseminate evidence-based information on the balance of benefits and risks could help to reduce the osteoporosis treatment gap and mitigate the crisis in osteoporosis care.

journal_name

J Endocrinol Invest

authors

Cipriani C,Pepe J,Minisola S,Lewiecki EM

doi

10.1007/s40618-018-0898-9

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1359-1364

issue

12

eissn

0391-4097

issn

1720-8386

pii

10.1007/s40618-018-0898-9

journal_volume

41

pub_type

杂志文章,评审
  • Comparison of immuno- and HPLC-assays for the measurement of urinary collagen cross-links.

    abstract::Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349673

    authors: Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

    更新日期:1994-09-01 00:00:00

  • Pre-operative micronutrient deficiencies in patients with severe obesity candidates for bariatric surgery.

    abstract:PURPOSE:In patients with obesity, micronutrient deficiencies have been reported both before and after bariatric surgery (BS). Obesity is a chronic pro-inflammatory status, and inflammation increases the risk of micronutrient malnutrition. Our objective was to assess in pre-BS patients the prevalence of micronutrient de...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01439-7

    authors: Pellegrini M,Rahimi F,Boschetti S,Devecchi A,De Francesco A,Mancino MV,Toppino M,Morino M,Fanni G,Ponzo V,Marzola E,Abbate Daga G,Broglio F,Ghigo E,Bo S

    更新日期:2020-10-07 00:00:00

  • Modulating effect of leptin on basal and follicle stimulating hormone stimulated steroidogenesis in cultured human lutein granulosa cells.

    abstract:BACKGROUND:In vitro data have shown conflicting results in terms of the effect of leptin on granulosa cells steroidogenesis. AIM:The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. MATERI...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346478

    authors: Karamouti M,Kollia P,Kallitsaris A,Vamvakopoulos N,Kollios G,Messinis IE

    更新日期:2009-05-01 00:00:00

  • Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome.

    abstract::Regulation of the hypothalamic-pituitary-thyroid (HPT) axis is dependent upon the secretion of thyrotropin-releasing hormone (TRH), a tripeptide originating in the hypothalamic paraventricular nucleus (PVN). These so-called hypophysiotropic neurons are under feedback inhibition by circulating levels of thyroid hormone...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Lechan RM,Fekete C

    更新日期:2004-01-01 00:00:00

  • The growth hormone response to hexarelin in patients with Prader-Willi syndrome.

    abstract::Hexarelin (Hex) is a synthetic hexapeptide with potent GH-releasing activity in both animals and men. Aim of this study was to evaluate the GH response to a maximal dose of Hex and GH-releasing hormone (GHRH) in a group of patients with Prader-Willi syndrome (PWS). Seven patients (4 boys and 3 girls, age 2.4-14.2 yr) ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347335

    authors: Cappa M,Raguso G,Palmiotto T,Faedda A,Gurreri F,Neri G,Deghenghi R,Loche S

    更新日期:1998-09-01 00:00:00

  • Post-partum hypocalcemia: idiopatic hypoparathyroidism manifested early in lactation.

    abstract::Hypocalcemia associated with labor and lactation is a rare condition reported previously in patients with hypovitaminosis D. We here describe a case of a young woman in whom symptomatic severe hypocalcemia appeared after her second delivery, early in lactation. At the end of lactation the condition worsened. We review...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345501

    authors: Durst R,Meirovitz A,Gross D,Kolker O,Muszkat M

    更新日期:2002-06-01 00:00:00

  • Exendin-4 protects murine MIN6 pancreatic β-cells from interleukin-1β-induced apoptosis via the NF-κB pathway.

    abstract:BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its potent analog, exendin-4, are well known to inhibit β- cell apoptosis and promote β-cell proliferation. Meanwhile, cytokines, such as interleukin-1β (IL-1β), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to β-cell d...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8938

    authors: Liu XH,Wang YP,Wang LX,Chen Z,Liu XY,Liu LB

    更新日期:2013-11-01 00:00:00

  • Raloxifene: bone and cardiovascular effects.

    abstract::Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal wome...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Francucci CM,Romagni P,Boscaro M

    更新日期:2005-01-01 00:00:00

  • Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters.

    abstract::To investigate the impact of obstructive sleep apnea syndrome (OSAS) on testosterone levels and on the main parameters of the metabolic syndrome in abdominally obese men, 15 male subjects with abdominal obesity phenotype and polysomnographic diagnosis of OSAS (OB-OSAS) and 15 controls matched for age and anthropometri...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345209

    authors: Gambineri A,Pelusi C,Pasquali R

    更新日期:2003-06-01 00:00:00

  • A novel heterozygous missense mutation in the vasopressin moiety is identified in a Japanese person with neurohypophyseal diabetes insipidus.

    abstract::The autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by diverse mutations in one allele of the gene that encodes the arginine vasopressin (AVP) precursor protein, AVP-neurophysin II (AVP-NP II). Most of the mutations identified so far are located in either the signal peptide or NP II ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345549

    authors: Kobayashi H,Fujisawa I,Ikeda K,Son C,Iwakura T,Yoshimoto A,Kasahara M,Ishihara T,Ogawa Y

    更新日期:2006-03-01 00:00:00

  • Alterations of gut microbiota composition in post-finasteride patients: a pilot study.

    abstract:PURPOSE:Post-finasteride syndrome (PFS) has been reported in a subset of patients treated with finasteride (an inhibitor of the enzyme 5alpha-reductase) for androgenetic alopecia. These patients showed, despite the suspension of the treatment, a variety of persistent symptoms, like sexual dysfunction and cognitive and ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01424-0

    authors: Borgo F,Macandog AD,Diviccaro S,Falvo E,Giatti S,Cavaletti G,Melcangi RC

    更新日期:2020-09-19 00:00:00

  • Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients. A randomized, double blind trial.

    abstract:BACKGROUND:Elevated plasminogen activator inhibitor type 1 (PAI 1) plays an important role in the pathogenesis of excess blood coagulability in obese patients. L-arginine supplementation has shown to be associated with enhanced cardiovascular and metabolic health. The aim of the study was to assess the effect of L-argi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.3275/8467

    authors: Bogdanski P,Szulinska M,Suliburska J,Pupek-Musialik D,Jablecka A,Witmanowski H

    更新日期:2013-04-01 00:00:00

  • Association between bone mineral density and nonalcoholic fatty liver disease in Korean adults.

    abstract:PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is associated with various metabolic abnormalities that can increase the risk of an osteoporotic fracture. Across the few previous studies of the association between NAFLD and bone mineral density (BMD), the association was not consistent. We examined the association bet...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-016-0528-3

    authors: Lee SH,Yun JM,Kim SH,Seo YG,Min H,Chung E,Bae YS,Ryou IS,Cho B

    更新日期:2016-11-01 00:00:00

  • Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.

    abstract::The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Yakar S,Pennisi P,Kim CH,Zhao H,Toyoshima Y,Gavrilova O,LeRoith D

    更新日期:2005-01-01 00:00:00

  • Effects of opioid receptor blockade on luteinizing hormone (LH) pulses and interpulse LH concentrations in normal women during the early phase of the menstrual cycle.

    abstract::To determine the role of endogenous opioid peptides in regulating pulsatile luteinizing hormone (LH) release in the early follicular phase of the menstrual cycle of eumenorrheic women, we evaluated serum LH concentrations in blood collected every 10 min for 12 h in 27 women each studied during two menstrual cycles: (1...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348799

    authors: Evans WS,Weltman JY,Johnson ML,Weltman A,Veldhuis JD,Rogol AD

    更新日期:1992-07-01 00:00:00

  • Transoral thyroidectomy: a viable surgical option with unprecedented complications-a case series.

    abstract:PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0808-6

    authors: Bakkar S,Al Hyari M,Naghawi M,Corsini C,Miccoli P

    更新日期:2018-07-01 00:00:00

  • Biochemical and immunohistochemical characterization of proteins in Hürthle cell carcinoma.

    abstract::The present study reports the biochemical and immunohistochemical findings in the cytosol of a Hürthle cell carcinoma as compared with that of normal thyroid tissue. Sephadex G-200 chromatography of the extract derived from a Hürthle cell carcinoma and from normal thyroid tissue revealed three identical pools. Pool I ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348449

    authors: De Keyser L,Layfield L,Van Herle A,Costin A,Lewin K

    更新日期:1984-10-01 00:00:00

  • Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion.

    abstract::Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...

    journal_title:Journal of endocrinological investigation

    pub_type:

    doi:

    authors: Valenti G

    更新日期:2002-01-01 00:00:00

  • Estrogen and progesterone receptors in the human vagina.

    abstract::Estrogen (E) and progesterone (Pg) receptor (R) levels were determined in the human vagina in relation to menopausal status, day of ovarian cycle and pregnancy. The results obtained confirmed that the human vagina contains ER and, in addition, demonstrated for the first time the presence of PgR in this organ in humans...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350667

    authors: Di Carlo F,Racca S,Gallo E,Conti G,Russo A,Mondo F,Francalanci S

    更新日期:1985-04-01 00:00:00

  • Lack of effect of the dopamine D1 antagonist, NNC 01-0687, on unstimulated and stimulated release of anterior pituitary hormones in males.

    abstract::Dopamine in humans inhibits the secretion of luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH) and prolactin (PRL), and is a stimulator of growth hormone (GH) secretion. Dopamine-D1 receptor stimulation with fenoldopam increases basal PRL levels, suppresses TSH, and incr...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03350331

    authors: Grodum E,Andersen M,Hangaard J,Koldkjaer O,Hagen C

    更新日期:1998-05-01 00:00:00

  • Premarin priming does not alter growth hormone release following exercise.

    abstract::We evaluated the usefulness of premarin priming on exercise induced growth hormone release and the value of combining several growth hormone screening agents in a large population of prepubertal children. Two hundred five short healthy prepubertal children growing below the 5th percentile in height were studied. One h...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346963

    authors: Lanes R,Lifshitz F,Sekaran C,Fort P,Recker B

    更新日期:1986-12-01 00:00:00

  • Principles and clinical applications of liquid chromatography - tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones.

    abstract::Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.3275/7843

    authors: Kulle AE,Welzel M,Holterhus PM,Riepe FG

    更新日期:2011-10-01 00:00:00

  • Circulating endogenous digitalis-like factor(s) (EDLF) in man is derived from the adrenals and its secretion is ACTH-dependent.

    abstract::Adrenal origin and ACTH-dependent secretion of endogenous digitalis-like factor(s) (EDLF) was investigated. Twelve normal weight normotensive subjects (normal group) and 10 patients with Addison's disease (Addison group) were subjected to prolonged ACTH stimulation with 1 mg tetracosactin-depot im. Blood sampling was ...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347027

    authors: Sophocleous A,Elmatzoglou I,Souvatzoglou A

    更新日期:2003-07-01 00:00:00

  • Psychosocial issues of ART in aging male.

    abstract::The role of androgens in human sexuality as regards the mechanism of erection and the pathogenesis of impotence is under debate. In addition, it is difficult to define the psychosocial impact of both hypogonadism and androgen replacement. However, sexual hormones largely influence mood, well-being, and quality of life...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Carosa E,Volpe R,Martini P,Brandetti F,Di Stasi SM,Lombardo F,Salacone P,Sgrò P,Gandini L,Lenzi A,Jannini EA

    更新日期:2005-01-01 00:00:00

  • Immunoreactive thyroglobulin in sera and saliva of patients with various thyroid disorders: role of autoantibodies.

    abstract::The present study was designed to assess the transfer of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) to saliva in subjects with positive TgAb in their sera. Group I consisted of normal euthyroid control subjects (n = 10). Group II were patients with various thyroid disorders and no TgAb in their sera (n = 6). Gro...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349955

    authors: Van Herle AJ,Rosenblit PD,Van Herle TL,Van Herle P,Greipel M,Kellett K

    更新日期:1989-03-01 00:00:00

  • Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study.

    abstract:PURPOSE:We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment. METHODS:We studied 711 children (me...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s40618-015-0418-0

    authors: Cappa M,Iughetti L,Loche S,Maghnie M,Vottero A,GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators.

    更新日期:2016-06-01 00:00:00

  • The effect of methimazole on the immune system is unlikely to operate directly on T lymphocytes.

    abstract::It has been shown that the antithyroid drug methimazole (MMI) may affect B cells and possibly accessory cell function. In the present study we investigated in detail the effects of MMI on T cell in vitro proliferation. The following variables were evaluated: T cell proliferation following stimulation with phytohemaggl...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348606

    authors: Bagnasco M,Venuti D,Ciprandi G,Pesce G,Paolieri F,Canonica GW

    更新日期:1990-06-01 00:00:00

  • Increased prevalence of primary hyperparathyroidism in treated breast cancer.

    abstract:UNLABELLED:Hypercalcemia occurring in patients with advanced breast cancer (BC) is generally due to osteolytic metastases or to the activity of circulating tumor-derived products. In these conditions, the production of endogenous PTH is reduced. The frequency of hypercalcemia due to primary hyperparathyroidism in breas...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343867

    authors: Fierabracci P,Pinchera A,Miccoli P,Conte PF,Vignali E,Zaccagnini M,Marcocci C,Giani C

    更新日期:2001-05-01 00:00:00

  • Effect of propranolol on aldosterone response to heat exposure in sodium-restricted men.

    abstract::To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03349377

    authors: Brandenberger G,Follenius M,Oyono S

    更新日期:1980-10-01 00:00:00

  • Minimally invasive video-assisted parathyroidectomy. Initial experience in a General Surgery Department.

    abstract:BACKGROUND:The aim of this study is to analyze our preliminary results from minimally invasive video-assisted parathyroidectomy (MIVAP) and demonstrate the feasibility of MIVAP also in non-referral centers. MATERIAL AND METHODS:During a period from June 2005 to January 2008, in the General Surgery Department of Univer...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345701

    authors: Dobrinja C,Trevisan G,Liguori G

    更新日期:2009-02-01 00:00:00