Abstract：
BACKGROUND:Ocular coloboma is an excavation of ocular structures that occurs due to abnormal fusion of the embryonic optic fissure. Further, cleft lip/palate (CL/P), a congenital midline abnormality, is caused by a defect in the fusion of the frontonasal, maxillary, and mandibular prominences. No study has reported the association between these two phenotypes in the absence of other systemic abnormalities. We present a case of ocular coloboma along with CL/P and without other neurological abnormalities. CASE PRESENTATION:A 5-year-old Asian boy presented with decreased visual acuity in his right eye. Physical examination revealed no abnormal findings except CL/P, which was surgically corrected at the age of 9 months. Best-corrected visual acuity was 20/60 in the right eye and 20/25 in the left eye. Anterior segment examination revealed iris coloboma in the inferior quadrant of his right eye as well as a large inferonasal optic disc and chorioretinal coloboma in the same eye. He was prescribed glasses based on his cycloplegic refractive errors and part-time occlusion of the left eye was recommended. After 3 months, best-corrected visual acuity improved to 20/30 in the right eye. CONCLUSION:The association of ocular coloboma should be kept in mind when encountering a patient with CL/P without other neurological or systemic abnormalities.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Yoo YJ,Han SB,Yang HK,Hwang JMdoi
10.1186/s12886-020-01696-3subject
Has Abstractpub_date
2020-10-19 00:00:00pages
418issue
1issn
1471-2415pii
10.1186/s12886-020-01696-3journal_volume
20pub_type
杂志文章abstract：BACKGROUND:The signaling pathway of epithelial to mesenchymal transition (EMT) is regulated by c-Src kinase in many cells. The purpose of this study was to investigate the effects of c-Src kinase on EMT of human lens epithelial cells in vivo stimulated by different factors. METHODS:Human lens epithelial cells, HLE-B3,...
journal_title：BMC ophthalmology
pub_type： 杂志文章
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更新日期：2019-11-08 00:00:00
abstract：BACKGROUND:Currently, various types of toric intraocular lenses (IOL) have been manufactured and can be divided into three types according to the location of correction component; front-toric IOL (correction on anterior IOL surface), back-toric IOL (correction on posterior IOL surface), and bi-toric IOL (correction on ...
journal_title：BMC ophthalmology
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journal_title：BMC ophthalmology
pub_type： 杂志文章
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abstract：BACKGROUND:Pseudoexfoliation syndrome (PXS) is the most common identifiable cause of secondary glaucoma, the prevalence of which varies considerably among different ethnicities. The aim of this study was to assess the prevalence of pseudoexfoliation syndrome in Pakistan. METHODS:A prospective study conducted in the pe...
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journal_title：BMC ophthalmology
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journal_title：BMC ophthalmology
pub_type： 杂志文章
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journal_title：BMC ophthalmology
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doi：10.1186/s12886-017-0503-6
更新日期：2017-07-04 00:00:00
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doi：10.1186/s12886-020-01549-z
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pub_type： 杂志文章
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更新日期：2016-07-19 00:00:00
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journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-29
更新日期：2011-09-26 00:00:00
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journal_title：BMC ophthalmology
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更新日期：2007-04-17 00:00:00
abstract：BACKGROUND:Orbital exenteration is a disfiguring procedure that aims to achieve local control. It is commonly a part of the management of malignant orbital tumor which is a life-threatening condition. It is necessary to determine predictive factors associated with overall survival (OS) following orbital exenteration. ...
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pub_type： 杂志文章
doi：10.1186/s12886-018-0850-y
更新日期：2018-07-28 00:00:00
abstract：BACKGROUND:To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and predicted lenticule thickness in SMILE. METHODS:A total of 184 eyes from 184 consecutive patients who underwent SMI...
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journal_title：BMC ophthalmology
pub_type： 临床试验,杂志文章
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abstract：BACKGROUND:Despite the progress in vitreoretinal surgery and the importance of silicone oil as an adjunct for the treatment of complex forms of retinal detachment, controversy still surrounds the issue of selecting the proper oil viscosity for clinical use. Herein, we evaluate the outcomes of retinal detachment (RD) su...
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doi：10.1186/1471-2415-6-21
更新日期：2006-05-31 00:00:00
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pub_type： 杂志文章
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更新日期：2012-07-29 00:00:00
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pub_type： 社论,评审
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更新日期：2006-06-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：BMC ophthalmology
pub_type： 杂志文章,已发布勘误
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更新日期：2020-07-31 00:00:00
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pub_type： 杂志文章,评审
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