Complement activation products in the circulation and urine of primary membranous nephropathy.

abstract：BACKGROUND:Diabetic nephropathy is a global common cause of chronic kidney disease and end-stage renal disease. A lot of research has been conducted in biomedical sciences, which has enhanced understanding of the pathophysiology of diabetic nephropathy and has expanded the potential available therapies. An increasing n...

journal_title：BMC nephrology

authors： De la Cruz-Cano E,Jiménez-González CDC,Morales-García V,Pineda-Pérez C,Tejas-Juárez JG,Rendón-Gandarilla FJ,Jiménez-Morales S,Díaz-Gandarilla JA

更新日期：2019-10-28 00:00:00

abstract：BACKGROUND:The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research imp...

journal_title：BMC nephrology

authors： Kieswich JE,Chen J,Alliouachene S,Caton PW,McCafferty K,Thiemermann C,Yaqoob MM

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and induce neutrophil degranulation in the filter and myeloperoxidase ...

journal_title：BMC nephrology

authors： Schilder L,Nurmohamed SA,ter Wee PM,Paauw NJ,Girbes AR,Beishuizen A,Beelen RH,Groeneveld AB

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs of haemodialysis in Sri Lanka and provide a framework for modeling similar financial audits. METHODS...

journal_title：BMC nephrology

authors： Ranasinghe P,Perera YS,Makarim MF,Wijesinghe A,Wanigasuriya K

更新日期：2011-09-06 00:00:00

abstract：BACKGROUND:Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. METHODS:An observational study (N = 1,099,292) with a nationally representative ...

journal_title：BMC nephrology

authors： Dmitrieva O,de Lusignan S,Macdougall IC,Gallagher H,Tomson C,Harris K,Desombre T,Goldsmith D

更新日期：2013-01-25 00:00:00

abstract：BACKGROUND:The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health systems in most sub-Sahara African countries have limited capacity in the form of trained and skilled h...

journal_title：BMC nephrology

authors： Furia FF,Shoo J,Ruggajo PJ,Kilonzo K,Basu G,Yeates K,Varughese S,Svarstad E,Kisanga O

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to test the antioxidant potential of the following ...

journal_title：BMC nephrology

authors： Assis RP,Castro JF,Gutierres VO,Arcaro CA,Brotto RS,Oliveira OM,Baviera AM,Brunetti IL

更新日期：2015-04-11 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk (reverse epidemiology effect) and the...

journal_title：BMC nephrology

authors： Junyent M,Martínez M,Borràs M,Coll B,Valdivielso JM,Vidal T,Sarró F,Roig J,Craver L,Fernández E

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis. METHODS:F...

journal_title：BMC nephrology

authors： Chen Y,Lin L,Tao X,Song Y,Cui J,Wan J

更新日期：2019-03-28 00:00:00

abstract：BACKGROUND:Sepsis is a common syndrome in critically ill patients and easily leads to the occurrence of acute kidney injury (AKI), with high mortality rates. This study aimed to investigate the diagnostic value of urine soluble CD163 (sCD163) for identification of sepsis, severity of sepsis, and for secondary AKI, and ...

journal_title：BMC nephrology

authors： Su L,Feng L,Liu C,Jiang Z,Li M,Xiao K,Yan P,Jia Y,Feng D,Xie L

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:Glomerular filtration rate (GFR) is the best index of renal function, but age, gender and ethnicity can putatively affect its values. The aim of this study was to establish reference values for GFR in healthy Brazilian subjects while taking these factors into account. METHODS:In this cross-sectional study, ...

journal_title：BMC nephrology

authors： Soares AA,Prates AB,Weinert LS,Veronese FV,de Azevedo MJ,Silveiro SP

更新日期：2013-02-28 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility of utilizing an in-vitro, closed loop hemodialysis system as a method to assess drug clearance. Secondarily, this study tested the influence of variables (blood flow rate, dialysate flow rate, and type of filter) in the hemodialysis procedure on the c...

journal_title：BMC nephrology

authors： Jang SM,Cardone KE,Nolin TD,Mason DL,Grabe DW

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:People with end stage renal disease (ESRD) face important health-related decisions concerning end-of-life care and the use of life-support technologies. While people often want to be involved in making decisions about their health, there are many challenges. People with advanced illness may have limited or w...

journal_title：BMC nephrology

authors： Kapell Brown C,Kryworuchko J,Martin W

更新日期：2018-09-12 00:00:00

abstract：BACKGROUND:The use of the Internet for searching and sharing health information and for health care interactions may have a great potential for Renal Transplant Recipients (RTR). This study aims to determine the characteristics associated with Internet and social network use in a representative sample of RTR at the tim...

journal_title：BMC nephrology

authors： Mouelhi Y,Alessandrini M,Pauly V,Dussol B,Gentile S

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS:Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels...

journal_title：BMC nephrology

authors： Collado S,Coll E,Nicolau C,Azqueta M,Pons M,Cruzado JM,de la Torre B,Deulofeu R,Mojal S,Pascual J,Cases A

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies. In the present study an attempt was made to investigate the effect of quinacrine, a phospholipase A...

journal_title：BMC nephrology

authors： Al Asmari AK,Al Sadoon KT,Obaid AA,Yesunayagam D,Tariq M

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral...

journal_title：BMC nephrology

authors： Hamoda RE,Gander JC,McPherson LJ,Arriola KJ,Cobb L,Pastan SO,Plantinga L,Browne T,Hartmann E,Mulloy L,Zayas C,Krisher J,Patzer RE

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:Atherosclerosis is regarded as a combination of two major separate diseases: atherosis and sclerosis. Sclerotic component depends on deterioration of elastic properties of the aortic wall and is called aortic stiffness. The most valuable, non-invasive method of aortic stiffness assessment is echocardiography...

journal_title：BMC nephrology

authors： Zapolski T,Furmaga J,Jaroszyński A,Wysocka A,Rudzki S,Wysokiński AP

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Urinary Ca2+ excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully understood. This study examined alterations in the expressions of renal Ca2+ transporters, channels a...

journal_title：BMC nephrology

authors： Yatabe MS,Yatabe J,Takano K,Murakami Y,Sakuta R,Abe S,Sanada H,Kimura J,Watanabe T

更新日期：2012-12-02 00:00:00

abstract：BACKGROUND:The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-h...

journal_title：BMC nephrology

authors： Dong Y,Wang Z,Chen Z,Wang X,Zhang L,Nie J,Zheng C,Wang J,Shao L,Tian Y,Gao R

更新日期：2018-02-17 00:00:00

abstract：BACKGROUND:Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremia and AKI within the first 72 h of intensive care unit (ICU) admission. METHODS:6490 ICU adult pati...

journal_title：BMC nephrology

authors： Yessayan L,Neyra JA,Canepa-Escaro F,Vasquez-Rios G,Heung M,Yee J,Acute Kidney Injury in Critical Illness Study Group.

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. METHODS:We characterized the frequency of AKI diagnostic testing for urine, blood, radiology, and pathology tests in all adult inpatients who w...

journal_title：BMC nephrology

authors： Leaf DE,Srivastava A,Zeng X,McMahon GM,Croy HE,Mendu ML,Kachalia A,Waikar SS

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the self-management education needs for patients with co-morbid diabetes and CKD and 2) co-develop an educa...

journal_title：BMC nephrology

authors： Zimbudzi E,Lo C,Kerr PG,Zoungas S

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS:Study Design: Cross-sectional study. SETTING AND PARTICIPANTS:Single center study of prevalent kidney transplant recipients from a transplant clin...

journal_title：BMC nephrology

authors： Gupta A,Mahnken JD,Johnson DK,Thomas TS,Subramaniam D,Polshak T,Gani I,John Chen G,Burns JM,Sarnak MJ

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:A positive pregnancy test in acute or chronically ill patients has implications for the use of potentially mutagenic or teratogenic products in urgent medical therapies such as the use of chemotherapies or therapies with immunosuppressants, for anesthesia, and for time-sensitive indications like urgent surge...

journal_title：BMC nephrology

authors： Haninger-Vacariu N,Herkner H,Lorenz M,Säemann M,Vychytil A,Jansen M,Marculescu R,Kramar R,Sunder-Plassmann G,Schmidt A

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined. CASE PRESENTATION:A 73-years-old male with 5-year history of proteinuria un...

journal_title：BMC nephrology

authors： Shimada M,Fujita T,Nakamura N,Narita I,Shimaya Y,Murakami R,Yamabe H,Osawa H,Okumura K

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Obstetric-related acute kidney injury (AKI) is thought to be a key contributor to the overall burden of AKI in low resource settings, causing significant and preventable morbidity and mortality. However, epidemiological data to corroborate these hypotheses is sparse. This prospective observational study aims...

journal_title：BMC nephrology

authors： Cooke WR,Hemmilä UK,Craik AL,Mandula CJ,Mvula P,Msusa A,Dreyer G,Evans R

更新日期：2018-02-02 00:00:00

abstract：BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RE...

journal_title：BMC nephrology

authors： Raghavendra A,Siji A,Sridhar TS,Phadke K,Vasudevan A

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use in this context. We sought to determine factors associated with NTHC use and examine regional and fac...

journal_title：BMC nephrology

authors： Clark EG,Akbari A,Hiebert B,Hiremath S,Komenda P,Lok CE,Moist LM,Schachter ME,Tangri N,Sood MM

更新日期：2016-02-27 00:00:00

abstract：BACKGROUND:Polycystic Kidney Disease (PKD) kidneys exhibit increased extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We investigated the role of these increases on cystic disease progression in PKD kidneys. METHODS:We examined the role of type I collagen (collagen I) and membrane...

journal_title：BMC nephrology

authors： Liu B,Li C,Liu Z,Dai Z,Tao Y

更新日期：2012-09-11 00:00:00