Abstract：
Background:Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods:We used the South Korean National Health Insurance Service National Sample Cohort database for this nationwide case-control study. Of the 1 million participants, 6417 participants with NODM in 2012-2013 and 32,085 controls without diabetes (1:5 propensity score matched with age, sex, index year, and year of diabetes diagnosis) were included. In these patients, we examined the statin prescription record for 3 years preceding the outcome. We used conditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results:After adjustment of covariates, there were no significant differences in the risk of NODM when analyzed according to cumulative use days. The risk of NODM was increased only in the short-term and recent user group (OR 1.48, 95% CI 1.21 to 1.82) whose cumulative prescription days are less than 6 months and whose last prescription is within 6 months of diagnosis. Conclusions:The risk of NODM was not associated with an increase in the cumulative duration of statin use or with non-recent use. Only recent short-term use of statin was associated with an increased risk of NODM. Diabetes screening are warranted during initial statin therapy.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Kim DW,Kim DH,Park JH,Choi M,Kim S,Kim H,Seul DE,Park SG,Jung JH,Han K,Park YGdoi
10.1186/s13098-019-0427-9subject
Has Abstractpub_date
2019-04-22 00:00:00pages
30issn
1758-5996pii
427journal_volume
11pub_type
杂志文章abstract：BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-5-48
更新日期：2013-08-31 00:00:00
abstract：: The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims t...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-11
更新日期：2011-06-15 00:00:00
abstract：Background:To investigate the association of low carbohydrate diet (LCD) score with the risk of type 2 diabetes among adults. Methods:This cohort study was conducted on 4356 healthy participants aged ≥ 19 years old, who were followed-up for a mean duration of 3 years within the framework of the Tehran Lipid and Glucos...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00596-2
更新日期：2020-10-07 00:00:00
abstract：Background:Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0387-5
更新日期：2018-11-22 00:00:00
abstract：Background:Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. However, despite aggre...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-019-0403-4
更新日期：2019-01-23 00:00:00
abstract：BACKGROUND:The prevalence of metabolic syndrome (MetS) has increased in developing countries in recent decades. This syndrome, a clustering of metabolic abnormalities, has been correlated to various socioeconomic and behavioral variables. We investigated the prevalence and prevalence ratios (PR) of MetS and related fac...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-4-20
更新日期：2012-05-14 00:00:00
abstract：BACKGROUND:Using patient data from the GetGoal-Duo1, -L, and L-Asia trials, the objectives of this study were to evaluate and compare the impact of lixisenatide once-daily add-on treatment to basal insulin therapy ±oral antidiabetic drugs (OADs) among type 2 diabetes (T2DM) patients subdivided into groups, based on the...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0104-6
更新日期：2015-11-21 00:00:00
abstract：BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0134-8
更新日期：2016-03-08 00:00:00
abstract：BACKGROUND:Diabetes treatment requires specialized multi-professional teams, supplies for blood glucose monitoring and training for self-injections of human insulin or insulin analogues. The State Health Secretariat of the Federal District (SHS-FD) has dispensed insulin analogues by means of clinical validated protocol...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0061-0
更新日期：2015-08-18 00:00:00
abstract：BACKGROUND:Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to investigate the safety and efficacy of secondary prevention of cardiovascular diseases...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0272-7
更新日期：2017-09-19 00:00:00
abstract：BACKGROUND:Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a h...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0268-3
更新日期：2017-09-11 00:00:00
abstract：BACKGROUND:Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration l...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0271-8
更新日期：2017-09-22 00:00:00
abstract：OBJECTIVE:To translate and validate the instrument Diabetes Self-Management Profile (DSMP)-Conventional and Flexible Regimens into Brazilian Portuguese language in order to evaluate the quality of diabetes self-management in children and adolescents with type 1 diabetes and their caregivers. METHODS:DSMP was submitted...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0250-0
更新日期：2017-07-11 00:00:00
abstract：BACKGROUND:Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin resistance. Diabetic patients have a higher frequency of the IRS-1 Gly972Arg variant and this polym...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0026-3
更新日期：2015-04-02 00:00:00
abstract：BACKGROUND:The oral DPP-4 inhibitors are new incretin-based therapies for treatment of type 2 diabetes. To assess the efficacy and safety of three DPP-4 inhibitors (Saxagliptin, Sitagliptin and Vildagliptin) as add-on therapy to dual combination of traditional oral hypoglycemic agents in Chinese type 2 diabetes patient...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-69
更新日期：2014-05-31 00:00:00
abstract：BACKGROUND:In most individuals, obesity and insulin resistance coexist. However, some individuals have excessive adipose tissue mass but remain insulin sensitive. Moreover, lean individuals can develop acute inflammation-induced insulin resistance, even without excess adipose tissue mass. OBJECTIVE:Our aim was to comp...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0125-9
更新日期：2016-02-09 00:00:00
abstract：:This manuscript reports the Brazilian Diabetes Society Position Statement for insulin adjustments based on trend arrows observed in continuous glucose monitoring systems. The Brazilian Diabetes Society supports the utilization of trend arrows for insulin dose adjustments in patients with diabetes on basal-bolus insuli...
journal_title：Diabetology & metabolic syndrome
pub_type： 信件
doi：10.1186/s13098-020-00607-2
更新日期：2021-01-03 00:00:00
abstract：BACKGROUND:Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). OBJECTIVES:Evaluate CIMT and its association with ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0190-0
更新日期：2016-11-11 00:00:00
abstract：Background:Adipokines are involved in the pathogenesis of metabolic disorders including obesity and type 2 diabetes mellitus (T2DM). This study investigates the levels of leptin, resistin, visfatin, secreted frizzled-related protein 5 (SFRP5), monocyte chemoattractant protein-1 (MCP-1) and retinol-binding protein 4 (RB...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0343-4
更新日期：2018-05-15 00:00:00
abstract：Background:No proper data on prognosis and management of type-2 diabetic ST elevation myocardial infarction (STEMI) patients with culprit obstructive lesion and multivessel non obstructive coronary stenosis (Mv-NOCS) exist. We evaluated the 12-months prognosis of Mv-NOCS-diabetics with first STEMI vs.to non-diabetics, ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0304-3
更新日期：2018-01-03 00:00:00
abstract：BACKGROUND:Type 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidn...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-016-0159-z
更新日期：2016-07-28 00:00:00
abstract：BACKGROUND:Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960'...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-2-5
更新日期：2010-01-21 00:00:00
abstract：Background:The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene-environment synergistic effect have not been extensively examined in, therefore, the purpose of this study is to explore the association between multiple S...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0492-0
更新日期：2019-11-27 00:00:00
abstract：Objective:Several controversial findings have been reported on treatment outcomes for diabetic stroke patients that received thrombolysis therapy in the hospital. We determined whether the association between telestroke technology, thrombolysis therapy and clinical risk factors in diabetic acute ischemic stroke may res...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0421-2
更新日期：2019-05-09 00:00:00
abstract：BACKGROUND:Dietary factors are important environmental factors associated with the prevalence of metabolic syndrome (MS). The objective of this study was to assess the habitual nutrient intakes of patients with MS. METHODS:A cross-sectional study included 103 patients (82 % women) with MS seen at the endocrinology out...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0147-3
更新日期：2016-04-14 00:00:00
abstract：BACKGROUND:An increase in the prevalence of obesity entails great expenditure for governments. Physical exercise is a powerful tool in the combat against obesity and obesity-associated diseases. This study sought to determine the effect of three different exercise protocols on metabolic syndrome and lipid peroxidation ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-35
更新日期：2011-12-19 00:00:00
abstract：BACKGROUND:The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS:A cross-sectional study was performed in newly diagnosed Chinese p...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-71
更新日期：2014-06-03 00:00:00
abstract：BACKGROUND AND AIM:A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00606-3
更新日期：2020-11-12 00:00:00
abstract：Background:Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have p...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0372-z
更新日期：2018-10-18 00:00:00
abstract：: In recent decades, Diabetes Mellitus has become a severe and growing global public healthcare problem due to the increase of its prevalence, morbidity and mortality. Post-transplant diabetes mellitus (PTDM) is a complication which takes place after a solid organ transplant, and its incidence is widely variable, rangi...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-1-14
更新日期：2009-10-05 00:00:00
