Abstract：
BACKGROUND:Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960's, is Delta9-tetrahydrocannabinol. On the other hand, the discovery of cannabinoid receptors and their endogenous agonists took place only very recently. In fact, the first cannabinoid receptor (CB1) was cloned in 1990, followed 3 years later by the characterization of a second cannabinoid receptor (CB2). Since the 19th century, the use of cannabis has been reported to stimulate appetite and increase the consumption of sweet and tasty food, sometimes resulting in significant weight gain. The recent description of the endocannabinoid system, not only in the central nervous system but also in peripheral tissues, points to its involvement in the regulation of appetite, food intake and energy metabolism. Consequently, the pharmacological modulation of the over-activity of this system could be useful in the treatment of the metabolic syndrome. CONCLUSIONS:The endocannabinoid system has important physiological functions not only in the central nervous system but also in peripheral tissues. The activation of central CB1 receptors, particularly in hypothalamic nuclei and in the limbic system, is involved in the regulation of feeding behavior, and especially in the control of the intake of palatable food. In the periphery, cannabinoid receptors are present in adipocytes, skeletal muscle, gastrointestinal tract and liver, modulating energy metabolism.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Tibiriça Edoi
10.1186/1758-5996-2-5subject
Has Abstractpub_date
2010-01-21 00:00:00pages
5issn
1758-5996pii
1758-5996-2-5journal_volume
2pub_type
杂志文章abstract：Background:The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms. Methods:Eighty-four consecutive type 2 diabetic patients with unstable angina (UA) were included from January 2018 to June 2018 to calculate calcification scores ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0464-4
更新日期：2019-08-19 00:00:00
abstract：BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-5-48
更新日期：2013-08-31 00:00:00
abstract：BACKGROUND:We investigated the effect of longitudinal status change in metabolic syndrome (MetS) assessed by two different criteria on new onset of type 2 diabetes (NODM) in a Japanese population. METHODS:The participants were 827 non-diabetic citizens who had undergone medical examinations in 1994 and 2003 or 2004. W...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0182-0
更新日期：2016-09-05 00:00:00
abstract：BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0134-8
更新日期：2016-03-08 00:00:00
abstract：BACKGROUND:Adherence to treatment has been defined as the degree to which a patient's behavior corresponds to medical or health advice; however, the most appropriate method to evaluate adherence to diabetes care has yet to be identified. We conducted analyses to compare adherence assessments and blood glucose monitorin...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0162-4
更新日期：2016-07-29 00:00:00
abstract：BACKGROUND:Number of diabetic patients under public primary care in Hong Kong rose from 150,157 (2009) to 173,015 (2013). This study aimed to track the 5-year change of their outcomes and care standard after the introduction of quality enhancement programmes. METHODS:Longitudinal study was conducted on a group of diab...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0072-x
更新日期：2015-09-17 00:00:00
abstract：BACKGROUND:An increase in the prevalence of obesity entails great expenditure for governments. Physical exercise is a powerful tool in the combat against obesity and obesity-associated diseases. This study sought to determine the effect of three different exercise protocols on metabolic syndrome and lipid peroxidation ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-35
更新日期：2011-12-19 00:00:00
abstract：Background:Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0387-5
更新日期：2018-11-22 00:00:00
abstract：BACKGROUND:Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). OBJECTIVES:Evaluate CIMT and its association with ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0190-0
更新日期：2016-11-11 00:00:00
abstract：:The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogu...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0037-0
更新日期：2015-06-26 00:00:00
abstract：:Women diagnosed with gestational diabetes mellitus have an increased risk of developing diabetes mellitus, which is a known risk factor for cardiovascular disease and insulin resistance. In the recently published article by Zajdenverg et al., they aimed to identify endothelial dysfunction and cardiovascular risk facto...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0023-6
更新日期：2015-03-19 00:00:00
abstract：BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-44
更新日期：2014-03-27 00:00:00
abstract：Background:Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2DM). Carotid intima-media thickness (CIMT) is considered a preclinical stage of atherosclerosis. Therefore, it is necessary to identify the related risk factors for CIMT to facilitate the early pr...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-0517-8
更新日期：2020-01-28 00:00:00
abstract：Objective:Several controversial findings have been reported on treatment outcomes for diabetic stroke patients that received thrombolysis therapy in the hospital. We determined whether the association between telestroke technology, thrombolysis therapy and clinical risk factors in diabetic acute ischemic stroke may res...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0421-2
更新日期：2019-05-09 00:00:00
abstract：BACKGROUND:Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to investigate the safety and efficacy of secondary prevention of cardiovascular diseases...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0272-7
更新日期：2017-09-19 00:00:00
abstract：BACKGROUND:Patients with either diabetes mellitus (DM) or metabolic syndrome (MS) are recognized as a high risk group for cardiovascular disease (CVD). Several studies have demonstrated the clinical value of MS for predicting additional CVD risk in the DM population, although the clinical significance remains debatable...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-98
更新日期：2014-09-12 00:00:00
abstract：BACKGROUND:The vascular complications of outpatients with diabetes at ordinary hospitals vary. Ischemic heart disease is barely predictable after treatment using previously reported therapeutic indices. We developed a simple and noninvasive screening method to evaluate the possibility of ischemic heart disease in patie...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-51
更新日期：2014-04-08 00:00:00
abstract：Background:Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose variability and psychological evaluations related to insulin regimen changes. We investigated changes in ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0366-x
更新日期：2018-08-16 00:00:00
abstract：BACKGROUND:In mammals, the temperature rhythm is regulated by the circadian pacemaker located in the suprachiasmatic nuclei, and is considered a "marker rhythm". Melatonin, the pineal gland hormone, is a major regulator of the endogenous rhythms including body temperature. Its production is influenced by many factors, ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0035-2
更新日期：2015-04-29 00:00:00
abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for patients with diabetes as a nephroprotector drug or to treat hypertension. Generally they are safe for clinical practice, but the relationship between these drugs and angioedema is known. The exact mechanism for ACE inhibitors-induced a...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-2-4
更新日期：2010-01-20 00:00:00
abstract：Background:Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have p...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0372-z
更新日期：2018-10-18 00:00:00
abstract：Background:In type I diabetes mellitus (T1DM) pancreatic β cells are destroyed. Treatment entails exogenous insulin administration and strict diet control, yet optimal glycemic control is hardly attainable. Islet transplant could be an alternative in patients with poor glycemic control, but inefficient islet purificati...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00573-9
更新日期：2020-08-05 00:00:00
abstract：BACKGROUND:Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. METHODS:Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00609-0
更新日期：2020-11-19 00:00:00
abstract：BACKGROUND:Comorbid depression in diabetes has been suggested as one of the possible causes of an inadequate glycemic control. The purpose of this study was to investigate the association between major depression and the glycemic control of type 2 diabetes mellitus (T2DM). METHODS:Seventy T2DM patients were evaluated....
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-26
更新日期：2011-10-07 00:00:00
abstract：Background:Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. However, despite aggre...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-019-0403-4
更新日期：2019-01-23 00:00:00
abstract：BACKGROUND:Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes s...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-017-0256-7
更新日期：2017-07-21 00:00:00
abstract：BACKGROUND:Distal symmetric polyneuropathy (DSPN) is the most common complication of type 2 diabetes mellitus (T2DM) and the most common form of peripheral neuropathy. DSPN increases the risk of foot ulceration up to seven-fold, and is a significant risk factor in more than 60 % of the amputations of the lower limbs in...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0146-4
更新日期：2016-04-11 00:00:00
abstract：BACKGROUND:Many self-management programs have been developed so far. Their effectiveness varies. The program 'Beyond Good Intentions' (BGI) is based on proactive coping and has proven to be (cost-) effective in achieving reductions in BMI and blood pressure in screen-detected type 2 diabetes patients up until nine mont...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0199-4
更新日期：2016-12-20 00:00:00
abstract：: The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims t...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-11
更新日期：2011-06-15 00:00:00
abstract：BACKGROUND:Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0149-1
更新日期：2016-05-03 00:00:00
