当前位置： SCI文献检索 > Diabetology & Metabolic Syndrome期刊下所有文献 > Degludec: the new ultra-long insulin analogue.

Degludec: the new ultra-long insulin analogue.

Abstract：

:The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogue degludec (IDeg) has the same amino acid sequence as human insulin except for the removal of threonine in the position 30 of the B chain (Des-B30, "De") and the attachment, via a glutamic acid linker ("glu"), of a 16-carbon fatty diacid (hexadecanoic diacid, "dec") to lysine in the position 29 of the B chain. These modifications allow that, after changing from the pharmaceutical formulation to the subcutaneous environment, IDeg precipitates in the subcutaneous tissue, forming a depot that undergoes a highly predictable gradual dissociation. Thus, once-daily dosing of IDeg results in a low peak: trough ratio, with consequent low intra-individual variability and plasmatic concentrations less critically dependent upon the time of injections. The clinical development program of IDeg (BEGIN) was comprised of 9 therapeutic confirmatory trials of longer duration (26-52 weeks) and showed that the efficacy of IDeg is comparable to insulin glargine in type 1 (T1D) and type 2 (T2D) diabetes patients across different age, body mass index and ethnic groups. This new ultra-long insulin analogue presents as advantages flexibility in dose timing and lower risk of hypoglycemia.

journal_name

Diabetol Metab Syndr

journal_title

Diabetology & metabolic syndrome

authors

Tambascia MA,Eliaschewitz FG

doi

10.1186/s13098-015-0037-0

subject

Has Abstract

pub_date

2015-06-26 00:00:00

pages

57

issn

1758-5996

pii

37

journal_volume

7

pub_type

杂志文章

相关文献

Diabetology & Metabolic Syndrome文献大全
  • Visceral adiposity index score indicated the severity of coronary heart disease in Chinese adults.

    abstract：BACKGROUND:Visceral adiposity contributes to cardiometabolic risk, and visceral adiposity index (VAI) had significant correlation with visceral adiposity. We aimed to explore whether VAI was associated with cardiac structure and function and assess the impact of the cut-off points of VAI defining visceral adipose dysfu...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-6-143

    authors： Han L,Fu KL,Zhao J,Wang ZH,Tang MX,Wang J,Wang H,Zhang Y,Zhang W,Zhong M

    更新日期：2014-12-22 00:00:00

  • Long non-coding RNA CDKN2B-AS1 regulates high glucose-induced human mesangial cell injury via regulating the miR-15b-5p/WNT2B axis.

    abstract：BACKGROUND:Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) has been reported to be related to diabetic nephropathy (DN) progression. However, the regulatory mechanisms of CDKN2B-AS1 in DN are unclear. METHODS:High glucose (HG) was used to induce human mesangial cells (HMCs) for es...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00618-z

    authors： Chang J,Yu Y,Fang Z,He H,Wang D,Teng J,Yang L

    更新日期：2020-12-09 00:00:00

  • Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes.

    abstract：Background:The role of serum fibroblast growth factor 19 (FGF19) in arteriosclerosis is not well known. In the present study, we aimed to explore whether serum FGF19 levels were related to arteriosclerosis parameters, including arterial stiffness and atherogenic index of plasma (AIP), in patients with type 2 diabetes (...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00552-0

    authors： Liu WS,Tang MJ,Xu TL,Su JB,Wang XQ,Xu F,Zhang DM,Zhu Q,Cao J,Wang H

    更新日期：2020-05-20 00:00:00

  • Association between statin treatment and new-onset diabetes mellitus: a population based case-control study.

    abstract：Background:Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods:We used the South Korean National Health Insurance S...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0427-9

    authors： Kim DW,Kim DH,Park JH,Choi M,Kim S,Kim H,Seul DE,Park SG,Jung JH,Han K,Park YG

    更新日期：2019-04-22 00:00:00

  • Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome.

    abstract：BACKGROUND:Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of alisk...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0282-5

    authors： Ramalho FN,Sanches SC,Foss MC,Augusto MJ,Silva DM,Oliveira AM,Ramalho LN

    更新日期：2017-10-13 00:00:00

  • Whether the risk of gestational diabetes mellitus is affected by TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis.

    abstract：Background:Whether polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10) or adiponectin (ADIPOQ) influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymo...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00582-8

    authors： Huang Q,Wang Y,Gu B,Xu Y

    更新日期：2020-09-17 00:00:00

  • Population attributable fractions for Type 2 diabetes: an examination of multiple risk factors including symptoms of depression and anxiety.

    abstract：Background:Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0387-5

    authors： Naicker K,Manuel D,Øverland S,Skogen JC,Johnson JA,Sivertsen B,Colman I

    更新日期：2018-11-22 00:00:00

  • Metabolic syndrome among Sri Lankan adults: prevalence, patterns and correlates.

    abstract：: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-4-24

    authors： Katulanda P,Ranasinghe P,Jayawardana R,Sheriff R,Matthews DR

    更新日期：2012-05-31 00:00:00

  • Effects of incretin treatment on cardiovascular outcomes in diabetic STEMI-patients with culprit obstructive and multivessel non obstructive-coronary-stenosis.

    abstract：Background:No proper data on prognosis and management of type-2 diabetic ST elevation myocardial infarction (STEMI) patients with culprit obstructive lesion and multivessel non obstructive coronary stenosis (Mv-NOCS) exist. We evaluated the 12-months prognosis of Mv-NOCS-diabetics with first STEMI vs.to non-diabetics, ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0304-3

    authors： Marfella R,Sardu C,Balestrieri ML,Siniscalchi M,Minicucci F,Signoriello G,Calabrò P,Mauro C,Pieretti G,Coppola A,Nicoletti G,Rizzo MR,Paolisso G,Barbieri M

    更新日期：2018-01-03 00:00:00

  • Interactions between kidney disease and diabetes: dangerous liaisons.

    abstract：BACKGROUND:Type 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidn...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章,评审

    doi：10.1186/s13098-016-0159-z

    authors： Pecoits-Filho R,Abensur H,Betônico CC,Machado AD,Parente EB,Queiroz M,Salles JE,Titan S,Vencio S

    更新日期：2016-07-28 00:00:00

  • A potential link between endothelial function, cardiovascular risk, and metabolic syndrome in patients with Non-alcoholic fatty liver disease.

    abstract：BACKGROUND:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthetase. Elevated ADMA reduces NO formation and is associated with endothelial dysfunction. The aims of this study were to evaluate endothelial function and the cardiovascular risk (CVR) profile in patients with...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-6-109

    authors： Sayki Arslan M,Turhan S,Dincer I,Mizrak D,Corapcioglu D,Idilman R

    更新日期：2014-10-14 00:00:00

  • Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children.

    abstract：BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0134-8

    authors： Al-Daghri NM,Khan N,Sabico S,Al-Attas OS,Alokail MS,Kumar S

    更新日期：2016-03-08 00:00:00

  • Anti-diabetic treatment regulates pro-fibrotic TGF-β serum levels in type 2 diabetics.

    abstract：BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-5-48

    authors： Pscherer S,Freude T,Forst T,Nussler AK,Braun KF,Ehnert S

    更新日期：2013-08-31 00:00:00

  • Impact of longitudinal status change in metabolic syndrome defined by two different criteria on new onset of type 2 diabetes in a general Japanese population: the Tanno-Sobetsu Study.

    abstract：BACKGROUND:We investigated the effect of longitudinal status change in metabolic syndrome (MetS) assessed by two different criteria on new onset of type 2 diabetes (NODM) in a Japanese population. METHODS:The participants were 827 non-diabetic citizens who had undergone medical examinations in 1994 and 2003 or 2004. W...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0182-0

    authors： Ohnishi H,Saitoh S,Akasaka H,Furukawa T,Mori M,Miura T

    更新日期：2016-09-05 00:00:00

  • Interaction between a variant of chromosome 9p21.3 locus and diet antioxidant capacity on metabolic syndrome in Tehrani adults.

    abstract：Background:Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have p...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0372-z

    authors： Mirzababaei A,Mollahosseini M,Rahimi MH,Yekaninejad MS,Maghbooli Z,Sobhani R,Mirzaei K

    更新日期：2018-10-18 00:00:00

  • Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?

    abstract：:Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancie...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-6-12

    authors： Zhou MS,Wang A,Yu H

    更新日期：2014-01-31 00:00:00

  • Results of glycated hemoglobin during treatment with insulin analogues dispensed in the public health system of Federal District in Brazil.

    abstract：BACKGROUND:Diabetes treatment requires specialized multi-professional teams, supplies for blood glucose monitoring and training for self-injections of human insulin or insulin analogues. The State Health Secretariat of the Federal District (SHS-FD) has dispensed insulin analogues by means of clinical validated protocol...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-015-0061-0

    authors： Leite EB,Pedrosa HC,Casulari LA

    更新日期：2015-08-18 00:00:00

  • Real-world flash glucose monitoring in Brazil: can sensors make a difference in diabetes management in developing countries?

    abstract：Background:New technologies are changing diabetes treatment and contributing better outcomes in developed countries. To our knowledge, no previous studies have investigated the comparative effect of sensor-based monitoring on glycemic markers in developing countries like Brazil. The present study aims to evaluate the u...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0513-z

    authors： Calliari LEP,Krakauer M,Vianna AGD,Ram Y,Barbieri DE,Xu Y,Dunn TC

    更新日期：2020-01-07 00:00:00

  • Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America.

    abstract：:Latin America is a fast-growing region that currently faces unique challenges in the treatment of all forms of diabetes mellitus. The burden of this disease will be even greater in the coming years due, in part, to the large proportion of young adults living in urban areas and engaging in unhealthy lifestyles. Unfortu...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章,评审

    doi：10.1186/s13098-019-0415-0

    authors： Solis MA,Moreno Velásquez I,Correa R,Huang LLH

    更新日期：2019-02-18 00:00:00

  • Prevalence of people at risk of developing type 2 diabetes mellitus and the involvement of community pharmacies in a national screening campaign: a pioneer action in Brazil.

    abstract：Background:Brazil is one of top 10 countries with the highest number of people with diabetes mellitus (DM), affecting 16.8 million peoples. It is estimated that 7.7 million people (20-79 years) in the country have not yet been diagnosed, representing an under-diagnosis rate of 46.0%. Herein we aimed to screen people fo...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00593-5

    authors： Correr CJ,Coura-Vital W,Frade JCQP,Nascimento RCRM,Nascimento LG,Pinheiro EB,Ferreira WM,Reis JS,Melo KFS,Pontarolo R,Lenzi MSA,Almeida JV,Pedrosa HC,João WSJ

    更新日期：2020-10-08 00:00:00

  • Translation and validation of diabetes self-management profile (DSMP) into Brazilian Portuguese language: first instrument to assess type 1 diabetes self-management in a pediatric population.

    abstract：OBJECTIVE:To translate and validate the instrument Diabetes Self-Management Profile (DSMP)-Conventional and Flexible Regimens into Brazilian Portuguese language in order to evaluate the quality of diabetes self-management in children and adolescents with type 1 diabetes and their caregivers. METHODS:DSMP was submitted...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0250-0

    authors： Passone CGB,Esteves LSO,Savoldelli RD,Harris MA,Damiani D,Manna TD

    更新日期：2017-07-11 00:00:00

  • Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population.

    abstract：Background:The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene-environment synergistic effect have not been extensively examined in, therefore, the purpose of this study is to explore the association between multiple S...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0492-0

    authors： Hou Y,Gao Y,Zhang Y,Lin ST,Yu Y,Yang L

    更新日期：2019-11-27 00:00:00

  • Twelve-week randomized study to compare the effect of vildagliptin vs. glibenclamide both added-on to metformin on endothelium function in patients with type 2 diabetes and hypertension.

    abstract：BACKGROUND:Vildagliptin, a DPP-4 inhibitor widely used for the treatment of type 2 diabetes mellitus (T2DM), shows beneficial effects on endothelial function. This study aims to evaluate the effect of vildagliptin on endothelial function and arterial stiffness in patients with T2DM and hypertension. METHODS:Fifty over...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-015-0062-z

    authors： Cosenso-Martin LN,Giollo-Júnior LT,Martineli DD,Cesarino CB,Nakazone MA,Cipullo JP,Vilela-Martin JF

    更新日期：2015-08-26 00:00:00

  • Oxidative DNA damage and oxidized low density lipoprotein in Type II diabetes mellitus among patients with Helicobacter pylori infection.

    abstract：BACKGROUND:Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0149-1

    authors： Nasif WA,Mukhtar MH,Nour Eldein MM,Ashgar SS

    更新日期：2016-05-03 00:00:00

  • A1C predicts type 2 diabetes and impaired glucose tolerance in a population at risk: the community diabetes prevention project.

    abstract：AIMS:In a population at risk for type 2 diabetes (T2DM), we assessed early physical and metabolic markers that predict progression from normal to impaired glucose tolerance (IGT) and T2DM. METHODS:A total of 388 individuals (22% male, age 46 + 11 years) at risk for T2DM were randomized to Standard (n = 182) or Interve...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-1-5

    authors： Leite SA,Anderson RL,Kendall DM,Monk AM,Bergenstal RM

    更新日期：2009-09-16 00:00:00

  • A qualitative study to explore the perception and behavior of patients towards diabetes management with physical disability.

    abstract：BACKGROUND:This study aimed to determine self-monitoring practices, awareness to dietary modifications and barriers to medication adherence among physically disabled type 2 diabetes mellitus patients. METHODS:Interview sessions were conducted at diabetes clinic-Penang general hospital. The invited participants represe...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0257-6

    authors： Gillani SW,Sulaiman SAS,Abdul MIM,Saad SY

    更新日期：2017-07-24 00:00:00

  • Allergic reaction related to ramipril use: a case report.

    abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for patients with diabetes as a nephroprotector drug or to treat hypertension. Generally they are safe for clinical practice, but the relationship between these drugs and angioedema is known. The exact mechanism for ACE inhibitors-induced a...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-2-4

    authors： Alencar RC,Cobas RA,Gomes MB

    更新日期：2010-01-20 00:00:00

  • Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials.

    abstract：Background:Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients. Methods:We performed ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0318-5

    authors： Balbi ME,Tonin FS,Mendes AM,Borba HH,Wiens A,Fernandez-Llimos F,Pontarolo R

    更新日期：2018-03-14 00:00:00

  • Metabolic syndrome in central Brazil: prevalence and correlates in the adult population.

    abstract：BACKGROUND:The prevalence of metabolic syndrome (MetS) has increased in developing countries in recent decades. This syndrome, a clustering of metabolic abnormalities, has been correlated to various socioeconomic and behavioral variables. We investigated the prevalence and prevalence ratios (PR) of MetS and related fac...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-4-20

    authors： Dutra ES,de Carvalho KM,Miyazaki E,Hamann EM,Ito MK

    更新日期：2012-05-14 00:00:00

  • The impact of a disease management programme for type 2 diabetes on health-related quality of life: multilevel analysis of a cluster-randomised controlled trial.

    abstract：Background:Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0330-9

    authors： Panisch S,Johansson T,Flamm M,Winkler H,Weitgasser R,Sönnichsen AC

    更新日期：2018-04-10 00:00:00