Abstract:
Background:No proper data on prognosis and management of type-2 diabetic ST elevation myocardial infarction (STEMI) patients with culprit obstructive lesion and multivessel non obstructive coronary stenosis (Mv-NOCS) exist. We evaluated the 12-months prognosis of Mv-NOCS-diabetics with first STEMI vs.to non-diabetics, and then Mv-NOCS-diabetics previously treated with incretin based therapy vs. a matched cohort of STEMI-Mv-NOCS never treated with such therapy. Methods:1088 Patients with first STEMI and Mv-NOCS were scheduled for the study. Patients included in the study were categorized in type 2 diabetics (n 292) and non-diabetics (n 796). Finally, we categorized diabetics in current-incretin-users (n 76), and never-incretin-users (n 180). The primary end point was all cause deaths, cardiac deaths, and major adverse cardiac events (MACE) at 12 months of follow up. Results:The study results evidenced higher percentage of all cause deaths (2.2% vs. 1.1%, p value 0.05), cardiac deaths (1.6% vs. 0.5%, p value 0.045), and MACE (12.9% vs. n 5.9%), p value 0.001) in diabetic vs. no diabetic patients at 12 months follow up. Among diabetic patients, the current vs never-incretin-users, did not present a significant difference about all cause of deaths, and cardiac deaths through 12-months. The MACE rate at 1 year was 7.4% in diabetic incretin-users STEMI Mv-NOCS patients vs. 12.9% in diabetic never-incretin-users STEMI-Mv-NOCS patients (p value 0.04). In a risk-adjusted hazard analysis, MACE through 12 months were lower in diabetic STEMI-Mv NOCS incretin-users vs never-incretin-users patients (HR 0.513, CI [0.292-0.899], p 0.021). Consequently, lower levels of glucagon-like peptide 1(GLP-1) were predictive of MACE at follow up (HR 1.528, CI [1.059-2.204], p 0.024). Conclusion:In type 2 diabetic patients with STEMI-Mv-NOCS, we observed higher incidence of 1-year mortality and adverse cardiovascular outcomes, as compared to non-diabetic STEMI-Mv-NOCS patients. In diabetic patients, never-incretin-users have worse prognosis as compared to current-incretin-users.Trail registration Clinical trial number: NCT03312179, name of registry: clinicaltrialgov, URL: clinicalltrialgov.com, date of registration: September 2017, date of enrollment first participant: September 2009.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Marfella R,Sardu C,Balestrieri ML,Siniscalchi M,Minicucci F,Signoriello G,Calabrò P,Mauro C,Pieretti G,Coppola A,Nicoletti G,Rizzo MR,Paolisso G,Barbieri Mdoi
10.1186/s13098-017-0304-3subject
Has Abstractpub_date
2018-01-03 00:00:00pages
1issn
1758-5996pii
304journal_volume
10pub_type
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-143
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abstract:BACKGROUND:The prevalence of metabolic syndrome (MetS) has increased in developing countries in recent decades. This syndrome, a clustering of metabolic abnormalities, has been correlated to various socioeconomic and behavioral variables. We investigated the prevalence and prevalence ratios (PR) of MetS and related fac...
journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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abstract:: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-4-24
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-48
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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journal_title:Diabetology & metabolic syndrome
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更新日期:2017-04-24 00:00:00
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0190-0
更新日期:2016-11-11 00:00:00
abstract:Background:Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. However, despite aggre...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章,评审
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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更新日期:2011-12-19 00:00:00
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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更新日期:2016-07-29 00:00:00