Abstract:
Background:There is lack of ideal and comprehensive economic evaluations of various GDM strategies. The aim of this study is to the compare efficacy and cost-effectiveness of five different methods of screening for gestational diabetes mellitus (GDM). Methods:This study is a randomized community non-inferiority trial among 30,000 pregnant women in five different geographic regions of Iran, who were randomly assigned to one of the five GDM screening methods. All first trimester pregnant women, seeking prenatal care in governmental health care systems, who met our eligibility criteria were enrolled. The criteria suggested by the International-Association-of-Diabetes-in-Pregnancy-Study-Group, the most intensive approach, were used as reference. We used the non-inferiority approach to compare less intensive strategies to the reference one. Along with routine prenatal standard care, all participants were scheduled to have two phases of GDM screening in first and second-trimester of pregnancy, based on five different pre-specified protocols. The screening protocol included fasting plasma glucose in the first trimester and either a one step or a two-step screening method in the second trimester of pregnancy. Pregnant women were classified in three groups based on the results: diagnosed with preexisting pre-gestational overt diabetes; gestational diabetes and non-GDM women. Each group received packages for standard-care and all participants were followed till delivery; pregnancy outcomes, quality of life and cost of health care were recorded in detail using specific standardized questionnaires. Primary outcomes were defined as % birth-weight > 90th percentile and primary cesarean section. In addition, we assessed the direct health care direct and indirect costs. Results:This study will enable us to compare the cost effectiveness of different GDM screening protocols and intervention intensity (low versus high). Conclusion:Results which if needed, will also enable policy makers to optimize the national GMD strategy as a resource for enhancing GDM guidelines.Trial registration Name of the registry: Iranian Registry of Clinical Trials. Trial registration number: IRCT138707081281N1. Date of registration: 2017-02-15. URL of trial registry record: https://www.irct.ir/trial/518.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Ramezani Tehrani F,Gulf Study Cooperative Research Group.doi
10.1186/s13098-019-0493-zsubject
Has Abstractpub_date
2019-12-18 00:00:00pages
106issn
1758-5996pii
493journal_volume
11pub_type
杂志文章abstract:Background:The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms. Methods:Eighty-four consecutive type 2 diabetic patients with unstable angina (UA) were included from January 2018 to June 2018 to calculate calcification scores ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-019-0464-4
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Visceral adiposity contributes to cardiometabolic risk, and visceral adiposity index (VAI) had significant correlation with visceral adiposity. We aimed to explore whether VAI was associated with cardiac structure and function and assess the impact of the cut-off points of VAI defining visceral adipose dysfu...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-143
更新日期:2014-12-22 00:00:00
abstract:BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-48
更新日期:2013-08-31 00:00:00
abstract:BACKGROUND:The aim of this study is to compare the efficacy of intensification of insulin treatment with insulin glargine and biphasic human insulin in patients with type 2 diabetes on concomitant therapy with oral antidiabetic drugs (OAD) in daily clinical practice. METHODS:A retrospective multicentre parallel two-ar...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-43
更新日期:2013-08-05 00:00:00
abstract::Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancie...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-12
更新日期:2014-01-31 00:00:00
abstract:BACKGROUND:Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. METHODS:Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-00609-0
更新日期:2020-11-19 00:00:00
abstract:BACKGROUND:Polymorphisms of vitamin D receptor (VDR) gene have been studied as genetic markers of type 1 diabetes mellitus (T1DM) and some studies have reported associations with autoimmune thyroid disease. The aim of this study was to evaluate the relationship between VDR FokI polymorphism (rs10735810), thyroid autoim...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0145-5
更新日期:2016-03-22 00:00:00
abstract:BACKGROUND:The objective was to evaluate the muscle glucose metabolism in rats fed a fructose-rich diet after fetal protein malnutrition, at rest and after acute physical exercise at maximal lactate steady-state intensity. METHODS:The male offspring born of mothers fed on a balanced or low-protein diet were split in f...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-118
更新日期:2014-11-06 00:00:00
abstract:Background:Adipokines are involved in the pathogenesis of metabolic disorders including obesity and type 2 diabetes mellitus (T2DM). This study investigates the levels of leptin, resistin, visfatin, secreted frizzled-related protein 5 (SFRP5), monocyte chemoattractant protein-1 (MCP-1) and retinol-binding protein 4 (RB...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-018-0343-4
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:This study aimed to determine self-monitoring practices, awareness to dietary modifications and barriers to medication adherence among physically disabled type 2 diabetes mellitus patients. METHODS:Interview sessions were conducted at diabetes clinic-Penang general hospital. The invited participants represe...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0257-6
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-44
更新日期:2014-03-27 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthetase. Elevated ADMA reduces NO formation and is associated with endothelial dysfunction. The aims of this study were to evaluate endothelial function and the cardiovascular risk (CVR) profile in patients with...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-109
更新日期:2014-10-14 00:00:00
abstract:BACKGROUND:Comorbid depression in diabetes has been suggested as one of the possible causes of an inadequate glycemic control. The purpose of this study was to investigate the association between major depression and the glycemic control of type 2 diabetes mellitus (T2DM). METHODS:Seventy T2DM patients were evaluated....
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-3-26
更新日期:2011-10-07 00:00:00
abstract:BACKGROUND:Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism. OBJECTIVE:The aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2) and correlate it with body fat distrib...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0226-0
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of alisk...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0282-5
更新日期:2017-10-13 00:00:00
abstract:Purpose:People with obesity have a compromised browning capacity of adipose tissue when faced with sympathetic stimuli. This study aimed to determine whether norepinephrine treatment can enhance the induction of precursor cells from human white adipose tissue to differentiate into adipocytes that express key markers of...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-00599-z
更新日期:2020-10-22 00:00:00
abstract:Background:In type I diabetes mellitus (T1DM) pancreatic β cells are destroyed. Treatment entails exogenous insulin administration and strict diet control, yet optimal glycemic control is hardly attainable. Islet transplant could be an alternative in patients with poor glycemic control, but inefficient islet purificati...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-00573-9
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960'...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-2-5
更新日期:2010-01-21 00:00:00
abstract:BACKGROUND:Diabetic retinopathy is the main cause of preventable blindness in the economically active population in western countries. Diabetic retinopathy screening is effective in preventing blindness and can be performed through various diagnostic methods. Our objective is to compare binocular indirect ophthalmoscop...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0110-8
更新日期:2015-12-21 00:00:00
abstract:: The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims t...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-3-11
更新日期:2011-06-15 00:00:00
abstract:Background:Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods:We used the South Korean National Health Insurance S...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-019-0427-9
更新日期:2019-04-22 00:00:00
abstract:BACKGROUND:Adherence to treatment has been defined as the degree to which a patient's behavior corresponds to medical or health advice; however, the most appropriate method to evaluate adherence to diabetes care has yet to be identified. We conducted analyses to compare adherence assessments and blood glucose monitorin...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0162-4
更新日期:2016-07-29 00:00:00
abstract:OBJECTIVE:To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH). METHODS:Electronic message was sent to members from Endocrinology Department- Brazilian Society of Pediatrics requesting clinical data for all cases of CHH. A whole blood...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-7-5
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a h...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0268-3
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0149-1
更新日期:2016-05-03 00:00:00
abstract:BACKGROUND:The prevalence of metabolic syndrome (MetS) has increased in developing countries in recent decades. This syndrome, a clustering of metabolic abnormalities, has been correlated to various socioeconomic and behavioral variables. We investigated the prevalence and prevalence ratios (PR) of MetS and related fac...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-4-20
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS:A cross-sectional study was performed in newly diagnosed Chinese p...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-71
更新日期:2014-06-03 00:00:00
abstract:Background:Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on the antioxidant status and glycemic index of type 2 diabetes mellitus patients. Methods:We performed ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-018-0318-5
更新日期:2018-03-14 00:00:00
abstract:OBJECTIVE:The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse cMetS based on receiver operating characteristic (ROC) curve analysis. METHODS:378 children aged 7 to ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-2-8
更新日期:2010-01-28 00:00:00
abstract:Background:Obesity is associated with several comorbidities, such as cardiovascular disease and type 2 diabetes mellitus, and may have its origin in early life stages, such as in the lactation period, through metabolic programming. Physical activity aids in decreasing the chances of developing cardiovascular and metabo...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-018-0374-x
更新日期:2018-09-26 00:00:00