当前位置： SCI文献检索 > Diabetology & Metabolic Syndrome期刊下所有文献 > Albumin binding ligands and albumin conjugate uptake by cancer cells.

Albumin binding ligands and albumin conjugate uptake by cancer cells.

Abstract：

: The scope of this short review is to summarise the knowledge gleaned from the fate of drugs transported by albumin upon contact with the target cancer cell or cells in inflamed tissues. The authors expertise covers covalently bound drugs and their cellular uptake and release from albumin. This review therefore aims to deduce what will happen to drugs such as insulin detemir which is considered to bind non-covalently to albumin and may have a fate similar to fatty acids transported by albumin.

journal_name

Diabetol Metab Syndr

journal_title

Diabetology & metabolic syndrome

authors

Frei E

doi

10.1186/1758-5996-3-11

subject

Has Abstract

pub_date

2011-06-15 00:00:00

pages

11

issue

1

issn

1758-5996

pii

1758-5996-3-11

journal_volume

3

pub_type

杂志文章

相关文献

Diabetology & Metabolic Syndrome文献大全
  • Long non-coding RNA CDKN2B-AS1 regulates high glucose-induced human mesangial cell injury via regulating the miR-15b-5p/WNT2B axis.

    abstract：BACKGROUND:Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) has been reported to be related to diabetic nephropathy (DN) progression. However, the regulatory mechanisms of CDKN2B-AS1 in DN are unclear. METHODS:High glucose (HG) was used to induce human mesangial cells (HMCs) for es...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00618-z

    authors： Chang J,Yu Y,Fang Z,He H,Wang D,Teng J,Yang L

    更新日期：2020-12-09 00:00:00

  • Association between aerobic capacity and the improvement in glycemic control after the exercise training in type 2 diabetes.

    abstract：BACKGROUND:We investigated the influence of aerobic capacity on the improvement in glycemic control achieved by long-term aerobic exercise in type 2 diabetes. METHODS:Fifty-three male patients with type 2 diabetes, recruited from outpatient clinics, wore multiple-memory accelerometers and were instructed to exercise a...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0262-9

    authors： Nojima H,Yoneda M,Watanabe H,Yamane K,Kitahara Y,Sekikawa K,Yamamoto H,Yokoyama A,Hattori N,Kohno N,Hiroshima University Health Promotion Study group.

    更新日期：2017-08-18 00:00:00

  • Glycemic variability is associated with vascular calcification by the markers of endoplasmic reticulum stress-related apoptosis, Wnt1, galectin-3 and BMP-2.

    abstract：Background:The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms. Methods:Eighty-four consecutive type 2 diabetic patients with unstable angina (UA) were included from January 2018 to June 2018 to calculate calcification scores ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0464-4

    authors： Zhang L,Sun H,Liu S,Gao J,Xia J

    更新日期：2019-08-19 00:00:00

  • Alleviating effects of morin against experimentally-induced diabetic osteopenia.

    abstract：UNLABELLED: BACKGROUND:Plant flavonoids are emerging as potent therapeutic drugs effective against a wide range of aging diseases particularly bone metabolic disorders. Morin (3,5,7,20,40-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and prot...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-5-5

    authors： Abuohashish HM,Al-Rejaie SS,Al-Hosaini KA,Parmar MY,Ahmed MM

    更新日期：2013-02-06 00:00:00

  • Comparison of adipokines in a cross-sectional study with healthy overweight, insulin-sensitive and healthy lean, insulin-resistant subjects, assisted by a family doctor primary care program.

    abstract：BACKGROUND:In most individuals, obesity and insulin resistance coexist. However, some individuals have excessive adipose tissue mass but remain insulin sensitive. Moreover, lean individuals can develop acute inflammation-induced insulin resistance, even without excess adipose tissue mass. OBJECTIVE:Our aim was to comp...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0125-9

    authors： Moscavitch SD,Kang HC,Filho RA,Mesquita ET,Neto HC,Rosa ML

    更新日期：2016-02-09 00:00:00

  • ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction.

    abstract：BACKGROUND:Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. METHODS:Anthropome...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-015-0027-2

    authors： de Oliveira R,Moraes TI,Cerda A,Hirata MH,Fajardo CM,Sousa MC,Dorea EL,Bernik MM,Hirata RD

    更新日期：2015-04-11 00:00:00

  • Interaction between a variant of chromosome 9p21.3 locus and diet antioxidant capacity on metabolic syndrome in Tehrani adults.

    abstract：Background:Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have p...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0372-z

    authors： Mirzababaei A,Mollahosseini M,Rahimi MH,Yekaninejad MS,Maghbooli Z,Sobhani R,Mirzaei K

    更新日期：2018-10-18 00:00:00

  • Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?

    abstract：:Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancie...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-6-12

    authors： Zhou MS,Wang A,Yu H

    更新日期：2014-01-31 00:00:00

  • Anti-diabetic treatment regulates pro-fibrotic TGF-β serum levels in type 2 diabetics.

    abstract：BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-5-48

    authors： Pscherer S,Freude T,Forst T,Nussler AK,Braun KF,Ehnert S

    更新日期：2013-08-31 00:00:00

  • Using trend arrows in continuous glucose monitoring systems for insulin adjustment in clinical practice: Brazilian Diabetes Society Position Statement.

    abstract：:This manuscript reports the Brazilian Diabetes Society Position Statement for insulin adjustments based on trend arrows observed in continuous glucose monitoring systems. The Brazilian Diabetes Society supports the utilization of trend arrows for insulin dose adjustments in patients with diabetes on basal-bolus insuli...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 信件

    doi：10.1186/s13098-020-00607-2

    authors： Rodacki M,Calliari LE,Ramalho AC,Vianna AGD,Franco DR,Melo KFS,Araujo LR,Krakauer M,Scharf M,Minicucci W,Ziegler R,Gabbay M

    更新日期：2021-01-03 00:00:00

  • The multiple functions of the endocannabinoid system: a focus on the regulation of food intake.

    abstract：BACKGROUND:Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960'...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-2-5

    authors： Tibiriça E

    更新日期：2010-01-21 00:00:00

  • Hormonal assessment of participants in a long distance walk.

    abstract：Background:Exercise can disrupt homeostasis and trigger many adaptive responses in different hormonal axes. The study of hormonal interactions with physical activity is highly complex due to the number of variables, such as exercise duration, exercise intensity, individual level of training, circadian rhythm, nutrition...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0414-1

    authors： de Souza HS,Jardim TV,Barroso WKS,de Oliveira Vitorino PV,Souza ALL,Jardim PCV

    更新日期：2019-02-15 00:00:00

  • Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus.

    abstract：BACKGROUND:Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1). OBJECTIVES:Evaluate CIMT and its association with ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0190-0

    authors： Fusaro MF,Zanini JL,Silva IN

    更新日期：2016-11-11 00:00:00

  • Degludec: the new ultra-long insulin analogue.

    abstract：:The development of extended-action insulin analogues was motivated by the unfavorable pharmacokinetic (PK) profile of the conventional long-acting insulin formulations, generally associated with marked inter and intra patient variability and site- and dose-dependent effect variation. The new ultra-long insulin analogu...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-015-0037-0

    authors： Tambascia MA,Eliaschewitz FG

    更新日期：2015-06-26 00:00:00

  • Mandatory oral glucose tolerance tests identify more diabetics in stable patients with chronic heart failure: a prospective observational study.

    abstract：BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-6-44

    authors： Stevens AL,Hansen D,Vandoren V,Westerlaken R,Creemers A,Eijnde BO,Dendale P

    更新日期：2014-03-27 00:00:00

  • The usefulness of quantifying intraepidermal nerve fibers density in the diagnostic of diabetic peripheral neuropathy: a cross-sectional study.

    abstract：BACKGROUND:Distal symmetric polyneuropathy (DSPN) is the most common complication of type 2 diabetes mellitus (T2DM) and the most common form of peripheral neuropathy. DSPN increases the risk of foot ulceration up to seven-fold, and is a significant risk factor in more than 60 % of the amputations of the lower limbs in...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-016-0146-4

    authors： Timar B,Popescu S,Timar R,Baderca F,Duica B,Vlad M,Levai C,Balinisteanu B,Simu M

    更新日期：2016-04-11 00:00:00

  • Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome.

    abstract：BACKGROUND:Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of alisk...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0282-5

    authors： Ramalho FN,Sanches SC,Foss MC,Augusto MJ,Silva DM,Oliveira AM,Ramalho LN

    更新日期：2017-10-13 00:00:00

  • Population attributable fractions for Type 2 diabetes: an examination of multiple risk factors including symptoms of depression and anxiety.

    abstract：Background:Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0387-5

    authors： Naicker K,Manuel D,Øverland S,Skogen JC,Johnson JA,Sivertsen B,Colman I

    更新日期：2018-11-22 00:00:00

  • Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial.

    abstract：Background:Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM) that favor both atherogenesis and ischemia and reperfusion injury (IRI). Sodium-glucose-2 co-transporter inhibitors (SGLT2i) may hypothetically improve microvascular and macrovascular functions via a broad spectrum of mechanisms, b...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0457-3

    authors： Cintra RMR,Soares AAS,Breder I,Munhoz DB,Barreto J,Kimura-Medorima ST,Cavalcante P,Zanchetta R,Breder JC,Moreira C,Virginio VW,Bonilha I,Lima-Junior JC,Coelho-Filho OR,Wolf VLW,Guerra-Junior G,Oliveira DC,Haeitmann R,

    更新日期：2019-07-31 00:00:00

  • Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management.

    abstract：Background:Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occur in a series of stages and is linked to glycemic and blood pressure control. However, despite aggre...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章,评审

    doi：10.1186/s13098-019-0403-4

    authors： Sulaiman MK

    更新日期：2019-01-23 00:00:00

  • The impact of a disease management programme for type 2 diabetes on health-related quality of life: multilevel analysis of a cluster-randomised controlled trial.

    abstract：Background:Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0330-9

    authors： Panisch S,Johansson T,Flamm M,Winkler H,Weitgasser R,Sönnichsen AC

    更新日期：2018-04-10 00:00:00

  • Cost effectiveness of different screening strategies for gestational diabetes mellitus screening: study protocol of a randomized community non-inferiority trial.

    abstract：Background:There is lack of ideal and comprehensive economic evaluations of various GDM strategies. The aim of this study is to the compare efficacy and cost-effectiveness of five different methods of screening for gestational diabetes mellitus (GDM). Methods:This study is a randomized community non-inferiority trial ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-019-0493-z

    authors： Ramezani Tehrani F,Gulf Study Cooperative Research Group.

    更新日期：2019-12-18 00:00:00

  • The relationship between insulin sensitivity and heart rate-corrected QT interval in patients with type 2 diabetes.

    abstract：BACKGROUND:Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a h...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0268-3

    authors： Yang XH,Su JB,Zhang XL,Zhao LH,Xu F,Wang XQ,Cheng XB

    更新日期：2017-09-11 00:00:00

  • Metabolic syndrome among Sri Lankan adults: prevalence, patterns and correlates.

    abstract：: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/1758-5996-4-24

    authors： Katulanda P,Ranasinghe P,Jayawardana R,Sheriff R,Matthews DR

    更新日期：2012-05-31 00:00:00

  • Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy.

    abstract：BACKGROUND AND AIM:A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00606-3

    authors： Neves JAJ,De Matos MR,Ramalho T,Santos-Bezerra DP,Cavalcante CDGD,Alpino Peixoto R,Queiroz MS,Jancar S,Correa-Giannella ML

    更新日期：2020-11-12 00:00:00

  • Whether the risk of gestational diabetes mellitus is affected by TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis.

    abstract：Background:Whether polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10) or adiponectin (ADIPOQ) influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymo...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-020-00582-8

    authors： Huang Q,Wang Y,Gu B,Xu Y

    更新日期：2020-09-17 00:00:00

  • Evaluation of the efficacy and safety of lixisenatide add-on treatment to basal insulin therapy among T2DM patients with different body mass indices from GetGoal trials.

    abstract：BACKGROUND:Using patient data from the GetGoal-Duo1, -L, and L-Asia trials, the objectives of this study were to evaluate and compare the impact of lixisenatide once-daily add-on treatment to basal insulin therapy ±oral antidiabetic drugs (OADs) among type 2 diabetes (T2DM) patients subdivided into groups, based on the...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-015-0104-6

    authors： Eto K,Naito Y,Seino Y

    更新日期：2015-11-21 00:00:00

  • Supportive and non-supportive interactions in families with a type 2 diabetes patient: an integrative review.

    abstract：BACKGROUND:Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes s...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章,评审

    doi：10.1186/s13098-017-0256-7

    authors： Bennich BB,Røder ME,Overgaard D,Egerod I,Munch L,Knop FK,Vilsbøll T,Konradsen H

    更新日期：2017-07-21 00:00:00

  • Moderate- to high-intensity statins for secondary prevention in patients with type 2 diabetes mellitus on dialysis after acute myocardial infarction.

    abstract：BACKGROUND:Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to investigate the safety and efficacy of secondary prevention of cardiovascular diseases...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-017-0272-7

    authors： Li YR,Tsai SS,Lin YS,Chung CM,Chen ST,Sun JH,Liou MJ,Chen TH

    更新日期：2017-09-19 00:00:00

  • Twice-daily insulin degludec/insulin aspart effectively improved morning and evening glucose levels and quality of life in patients previously treated with premixed insulin: an observational study.

    abstract：Background:Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose variability and psychological evaluations related to insulin regimen changes. We investigated changes in ...

    journal_title：Diabetology & metabolic syndrome

    pub_type： 杂志文章

    doi：10.1186/s13098-018-0366-x

    authors： Fujimoto K,Iwakura T,Aburaya M,Matsuoka N

    更新日期：2018-08-16 00:00:00