Abstract:
BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal muscle strength. METHODS:A prospective observational study was set up. Inclusion criteria were diagnosis of CHF, stable condition and absence of glucose-lowering medication. Patients underwent a 2 h oral glucose tolerance test (OGTT), isometric strength testing of the upper leg and dual energy x-ray absorptiometry. Health-related quality of life and physical activity level were assessed by questionnaire. RESULTS:Data of 56 participants were analyzed. Despite near-normal fasting glucose values, 55% was classified as prediabetic, 14% as diabetic, and 20% as normal glucose tolerant. Of all newly diagnosed diabetic patients, 79% were diagnosed because of 2 h glucose values only and none because of HbA1c. Univariate mixed model analysis revealed ischaemic aetiology, daily physical activity, E/E', fat trunk/fat limbs and extension strength as possible explanatory variables for the glucose curve during the glucose tolerance test. When combined in one model, only fat trunk/fat limbs and E/E' remained significant predictors. Furthermore, fasting insulin was correlated with fat mass/height2 (r = 0.51, p < 0.0001), extension strength (r = -0.33, p < 0.01) and triglycerides (r = 0.39, p < 0.01). CONCLUSIONS:Our data confirm that a large majority of CHF patients have impaired glucose tolerance. This glucose intolerance is related to fat distribution and left ventricular end-diastolic pressure.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Stevens AL,Hansen D,Vandoren V,Westerlaken R,Creemers A,Eijnde BO,Dendale Pdoi
10.1186/1758-5996-6-44subject
Has Abstractpub_date
2014-03-27 00:00:00pages
44issue
1issn
1758-5996pii
1758-5996-6-44journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0134-8
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journal_title:Diabetology & metabolic syndrome
pub_type: 信件
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0147-3
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章,评审
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-018-0374-x
更新日期:2018-09-26 00:00:00
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-51
更新日期:2014-04-08 00:00:00
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0035-2
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-43
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journal_title:Diabetology & metabolic syndrome
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-5
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-95
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0027-2
更新日期:2015-04-11 00:00:00
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-4-24
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-3-26
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0062-z
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章,评审
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-106
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journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
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pub_type: 杂志文章
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