Abstract:
:This manuscript reports the Brazilian Diabetes Society Position Statement for insulin adjustments based on trend arrows observed in continuous glucose monitoring systems. The Brazilian Diabetes Society supports the utilization of trend arrows for insulin dose adjustments in patients with diabetes on basal-bolus insulin therapy, both with multiple daily insulin doses or insulin pumps without closed-loop features. For those on insulin pumps with predictive low-glucose suspend feature, we suggest that only upward trend arrows should be used for adjustments. In this paper, tables for insulin adjustment based on sensitivity factors are provided and strategies to optimize the use of trend arrows in clinical practice are discussed.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Rodacki M,Calliari LE,Ramalho AC,Vianna AGD,Franco DR,Melo KFS,Araujo LR,Krakauer M,Scharf M,Minicucci W,Ziegler R,Gabbay Mdoi
10.1186/s13098-020-00607-2subject
Has Abstractpub_date
2021-01-03 00:00:00pages
2issue
1issn
1758-5996pii
10.1186/s13098-020-00607-2journal_volume
13pub_type
信件abstract:BACKGROUND:Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been shown to possess pleiotropic effects including body weight reduction. However, long-term effect of liraglutide on body weight and glycemic control has not been elucidated in Japanese type 2 diabetes (T2D) subjects. Present study investigates w...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-95
更新日期:2014-09-08 00:00:00
abstract:Purpose:People with obesity have a compromised browning capacity of adipose tissue when faced with sympathetic stimuli. This study aimed to determine whether norepinephrine treatment can enhance the induction of precursor cells from human white adipose tissue to differentiate into adipocytes that express key markers of...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-00599-z
更新日期:2020-10-22 00:00:00
abstract:: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-4-24
更新日期:2012-05-31 00:00:00
abstract:UNLABELLED: BACKGROUND:Achieving good glycemic control is of paramount importance in the reduction of diabetes mellitus (DM) associated morbidity and mortality. Insulin plays a key role in the management of DM but unfortunately whilst some healthcare providers present insulin as a treatment of last resort , patients o...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-4-50
更新日期:2012-12-02 00:00:00
abstract:BACKGROUND:Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to investigate the safety and efficacy of secondary prevention of cardiovascular diseases...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0272-7
更新日期:2017-09-19 00:00:00
abstract:Background:Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods:We used the South Korean National Health Insurance S...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-019-0427-9
更新日期:2019-04-22 00:00:00
abstract:BACKGROUND:Using patient data from the GetGoal-Duo1, -L, and L-Asia trials, the objectives of this study were to evaluate and compare the impact of lixisenatide once-daily add-on treatment to basal insulin therapy ±oral antidiabetic drugs (OADs) among type 2 diabetes (T2DM) patients subdivided into groups, based on the...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0104-6
更新日期:2015-11-21 00:00:00
abstract:OBJECTIVE:To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH). METHODS:Electronic message was sent to members from Endocrinology Department- Brazilian Society of Pediatrics requesting clinical data for all cases of CHH. A whole blood...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-7-5
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:In most individuals, obesity and insulin resistance coexist. However, some individuals have excessive adipose tissue mass but remain insulin sensitive. Moreover, lean individuals can develop acute inflammation-induced insulin resistance, even without excess adipose tissue mass. OBJECTIVE:Our aim was to comp...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0125-9
更新日期:2016-02-09 00:00:00
abstract:Background:Exercise can disrupt homeostasis and trigger many adaptive responses in different hormonal axes. The study of hormonal interactions with physical activity is highly complex due to the number of variables, such as exercise duration, exercise intensity, individual level of training, circadian rhythm, nutrition...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-019-0414-1
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-016-0149-1
更新日期:2016-05-03 00:00:00
abstract:UNLABELLED: BACKGROUND:Plant flavonoids are emerging as potent therapeutic drugs effective against a wide range of aging diseases particularly bone metabolic disorders. Morin (3,5,7,20,40-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and prot...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-5
更新日期:2013-02-06 00:00:00
abstract:BACKGROUND:Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960'...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-2-5
更新日期:2010-01-21 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthetase. Elevated ADMA reduces NO formation and is associated with endothelial dysfunction. The aims of this study were to evaluate endothelial function and the cardiovascular risk (CVR) profile in patients with...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-109
更新日期:2014-10-14 00:00:00
abstract:Background:There is lack of ideal and comprehensive economic evaluations of various GDM strategies. The aim of this study is to the compare efficacy and cost-effectiveness of five different methods of screening for gestational diabetes mellitus (GDM). Methods:This study is a randomized community non-inferiority trial ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-019-0493-z
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND AND AIM:A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-00606-3
更新日期:2020-11-12 00:00:00
abstract:Background:Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2DM). Carotid intima-media thickness (CIMT) is considered a preclinical stage of atherosclerosis. Therefore, it is necessary to identify the related risk factors for CIMT to facilitate the early pr...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-020-0517-8
更新日期:2020-01-28 00:00:00
abstract:OBJECTIVE:The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse cMetS based on receiver operating characteristic (ROC) curve analysis. METHODS:378 children aged 7 to ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-2-8
更新日期:2010-01-28 00:00:00
abstract:BACKGROUND:The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS:A cross-sectional study was performed in newly diagnosed Chinese p...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-71
更新日期:2014-06-03 00:00:00
abstract:BACKGROUND:The single-center, open-label, four-arm, exploratory study investigates the relation of different anti-diabetics to serum levels of active TGF-β, a known pro-fibrotic stimulus, before and after a defined test meal. FINDINGS:We investigated sera of patients with type 2 diabetes mellitus (T2DM) treated with m...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-5-48
更新日期:2013-08-31 00:00:00
abstract:BACKGROUND:Type 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidn...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章,评审
doi:10.1186/s13098-016-0159-z
更新日期:2016-07-28 00:00:00
abstract:BACKGROUND:We investigated the influence of aerobic capacity on the improvement in glycemic control achieved by long-term aerobic exercise in type 2 diabetes. METHODS:Fifty-three male patients with type 2 diabetes, recruited from outpatient clinics, wore multiple-memory accelerometers and were instructed to exercise a...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-017-0262-9
更新日期:2017-08-18 00:00:00
abstract:: In recent decades, Diabetes Mellitus has become a severe and growing global public healthcare problem due to the increase of its prevalence, morbidity and mortality. Post-transplant diabetes mellitus (PTDM) is a complication which takes place after a solid organ transplant, and its incidence is widely variable, rangi...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-1-14
更新日期:2009-10-05 00:00:00
abstract:BACKGROUND:Number of diabetic patients under public primary care in Hong Kong rose from 150,157 (2009) to 173,015 (2013). This study aimed to track the 5-year change of their outcomes and care standard after the introduction of quality enhancement programmes. METHODS:Longitudinal study was conducted on a group of diab...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0072-x
更新日期:2015-09-17 00:00:00
abstract:BACKGROUND:Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin resistance. Diabetic patients have a higher frequency of the IRS-1 Gly972Arg variant and this polym...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-015-0026-3
更新日期:2015-04-02 00:00:00
abstract:Background:Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/s13098-018-0330-9
更新日期:2018-04-10 00:00:00
abstract:BACKGROUND:The objective was to evaluate the muscle glucose metabolism in rats fed a fructose-rich diet after fetal protein malnutrition, at rest and after acute physical exercise at maximal lactate steady-state intensity. METHODS:The male offspring born of mothers fed on a balanced or low-protein diet were split in f...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-118
更新日期:2014-11-06 00:00:00
abstract:AIMS:In a population at risk for type 2 diabetes (T2DM), we assessed early physical and metabolic markers that predict progression from normal to impaired glucose tolerance (IGT) and T2DM. METHODS:A total of 388 individuals (22% male, age 46 + 11 years) at risk for T2DM were randomized to Standard (n = 182) or Interve...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-1-5
更新日期:2009-09-16 00:00:00
abstract:BACKGROUND:Patients with either diabetes mellitus (DM) or metabolic syndrome (MS) are recognized as a high risk group for cardiovascular disease (CVD). Several studies have demonstrated the clinical value of MS for predicting additional CVD risk in the DM population, although the clinical significance remains debatable...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-98
更新日期:2014-09-12 00:00:00
abstract:BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal ...
journal_title:Diabetology & metabolic syndrome
pub_type: 杂志文章
doi:10.1186/1758-5996-6-44
更新日期:2014-03-27 00:00:00