Abstract：
BACKGROUND:Using patient data from the GetGoal-Duo1, -L, and L-Asia trials, the objectives of this study were to evaluate and compare the impact of lixisenatide once-daily add-on treatment to basal insulin therapy ±oral antidiabetic drugs (OADs) among type 2 diabetes (T2DM) patients subdivided into groups, based on their baseline body mass indices (BMI). METHODS:Data of patients treated with lixisenatide were extracted from the modified intent-to-treat populations of the trials. Patients were subdivided into 4 groups based on baseline BMI category (BMIs <25, 25-<30, 30-<35, and ≥35 kg/m(2)). At the unadjusted data level, efficacy and safety endpoints were evaluated and compared among study cohorts. Additionally, multivariable regression analyses were used to specify key patient characteristics and then assess the adjusted outcomes. RESULTS:Of the 662 T2DM patients, the mean changes in HbA1c (-0.63 to -0.73 %, p = 0.88) and FPG levels (-3.9 to 3.2 mg/dL, p = 0.60) were not significantly different among the different BMI groups. The proportions of T2DM patients that achieved HbA1c <7 % ranged between 34.7 and 46.8 %. After adjusted for patient characteristics, T2DM patients in the lowest BMI group relative to those in the highest BMI group had a smaller reduction in HbA1c during the trial periods (difference: 0.32 %, confidence interval: 0.10, 0.53, p = 0.005) and were less likely to achieve HbA1c <7 %. CONCLUSIONS:The findings of this analysis of the GetGoal clinical trials suggest that lixisenatide may be a good treatment option for optimizing glycemic control in patients unable to achieve their HbA1c target on basal insulin therapy ±OADs, regardless of BMI category.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Eto K,Naito Y,Seino Ydoi
10.1186/s13098-015-0104-6subject
Has Abstractpub_date
2015-11-21 00:00:00pages
106issn
1758-5996pii
104journal_volume
7pub_type
杂志文章abstract：BACKGROUND:The aim of this study is to compare the efficacy of intensification of insulin treatment with insulin glargine and biphasic human insulin in patients with type 2 diabetes on concomitant therapy with oral antidiabetic drugs (OAD) in daily clinical practice. METHODS:A retrospective multicentre parallel two-ar...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-5-43
更新日期：2013-08-05 00:00:00
abstract：Background:Metabolic syndrome is characterized by macrophage infiltration and inflammatory responses-metaflammation in adipose tissue. IL-6 and IL-1β could mediate the inflammatory responses in macrophage stimulated-preadipocytes by modulating MAPK and NF-κB pathways. To test this hypothesis we used antibodies to block...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0405-2
更新日期：2019-01-25 00:00:00
abstract：BACKGROUND:Polymorphisms in genes encoding adiponectin (ADIPOQ) and interleukin-6 (IL6) have been associated with adiposity and obese-related phenotypes. This study investigated the relationship of ADIPOQ and IL6 gene polymorphisms with pro-inflammatory and cardiometabolic markers in obese patients. METHODS:Anthropome...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0027-2
更新日期：2015-04-11 00:00:00
abstract：BACKGROUND:The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS:A cross-sectional study was performed in newly diagnosed Chinese p...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-71
更新日期：2014-06-03 00:00:00
abstract：BACKGROUND:Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2 diabetic mice, and that periodontal pathogen Porphyromonas gingivalis LPS (Pg-LPS) administration l...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0271-8
更新日期：2017-09-22 00:00:00
abstract：UNLABELLED: BACKGROUND:Plant flavonoids are emerging as potent therapeutic drugs effective against a wide range of aging diseases particularly bone metabolic disorders. Morin (3,5,7,20,40-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and prot...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-5-5
更新日期：2013-02-06 00:00:00
abstract：BACKGROUND:Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes s...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-017-0256-7
更新日期：2017-07-21 00:00:00
abstract：Background:Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose variability and psychological evaluations related to insulin regimen changes. We investigated changes in ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0366-x
更新日期：2018-08-16 00:00:00
abstract：Background:The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene-environment synergistic effect have not been extensively examined in, therefore, the purpose of this study is to explore the association between multiple S...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0492-0
更新日期：2019-11-27 00:00:00
abstract：Background:Obesity is associated with several comorbidities, such as cardiovascular disease and type 2 diabetes mellitus, and may have its origin in early life stages, such as in the lactation period, through metabolic programming. Physical activity aids in decreasing the chances of developing cardiovascular and metabo...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0374-x
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:Adherence to treatment has been defined as the degree to which a patient's behavior corresponds to medical or health advice; however, the most appropriate method to evaluate adherence to diabetes care has yet to be identified. We conducted analyses to compare adherence assessments and blood glucose monitorin...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0162-4
更新日期：2016-07-29 00:00:00
abstract：Background:Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. Methods:We used the South Korean National Health Insurance S...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0427-9
更新日期：2019-04-22 00:00:00
abstract：BACKGROUND:Adipokines, e.g. TNFα, IL-6 and leptin increase insulin resistance, and consequent hyperinsulinaemia influences breast cancer progression. Beside its mitogenic effects, insulin may influence adipokine production from adipocyte stromal cells and paracrine enhancement of breast cancer cell growth. In contrast,...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-16
更新日期：2011-07-20 00:00:00
abstract：Background:In type I diabetes mellitus (T1DM) pancreatic β cells are destroyed. Treatment entails exogenous insulin administration and strict diet control, yet optimal glycemic control is hardly attainable. Islet transplant could be an alternative in patients with poor glycemic control, but inefficient islet purificati...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00573-9
更新日期：2020-08-05 00:00:00
abstract：Background:New technologies are changing diabetes treatment and contributing better outcomes in developed countries. To our knowledge, no previous studies have investigated the comparative effect of sensor-based monitoring on glycemic markers in developing countries like Brazil. The present study aims to evaluate the u...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0513-z
更新日期：2020-01-07 00:00:00
abstract：Objective:Several controversial findings have been reported on treatment outcomes for diabetic stroke patients that received thrombolysis therapy in the hospital. We determined whether the association between telestroke technology, thrombolysis therapy and clinical risk factors in diabetic acute ischemic stroke may res...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0421-2
更新日期：2019-05-09 00:00:00
abstract：:Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancie...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-12
更新日期：2014-01-31 00:00:00
abstract：Background:Exercise can disrupt homeostasis and trigger many adaptive responses in different hormonal axes. The study of hormonal interactions with physical activity is highly complex due to the number of variables, such as exercise duration, exercise intensity, individual level of training, circadian rhythm, nutrition...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0414-1
更新日期：2019-02-15 00:00:00
abstract：BACKGROUND:Galectin-3 is a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation. Galectin-3-deficient mice have been shown to exhibit excess adiposity, hyperglycemia, insulin resistance and systemic inflammation. We investigated the association between serum galec...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-106
更新日期：2014-09-27 00:00:00
abstract：:Latin America is a fast-growing region that currently faces unique challenges in the treatment of all forms of diabetes mellitus. The burden of this disease will be even greater in the coming years due, in part, to the large proportion of young adults living in urban areas and engaging in unhealthy lifestyles. Unfortu...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-019-0415-0
更新日期：2019-02-18 00:00:00
abstract：: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-4-24
更新日期：2012-05-31 00:00:00
abstract：OBJECTIVE:To study the clinical and molecular characteristics of a sample of Brazilian patients with Congenital Hyperinsulinemic Hypoglycemia (CHH). METHODS:Electronic message was sent to members from Endocrinology Department- Brazilian Society of Pediatrics requesting clinical data for all cases of CHH. A whole blood...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-7-5
更新日期：2015-02-18 00:00:00
abstract：BACKGROUND:The objective was to evaluate the muscle glucose metabolism in rats fed a fructose-rich diet after fetal protein malnutrition, at rest and after acute physical exercise at maximal lactate steady-state intensity. METHODS:The male offspring born of mothers fed on a balanced or low-protein diet were split in f...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-118
更新日期：2014-11-06 00:00:00
abstract：BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0134-8
更新日期：2016-03-08 00:00:00
abstract：Background:Diabetic nephropathy (DN) is a severe complication of diabetes with type 1 and 2. Long non-coding RNAs (lncRNAs) are being found to be involved in the DN pathogenesis. In this study, we aimed to further explore the effect and underlying mechanism of plasmacytoma variant translocation 1 (PVT1) in DN pathogene...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00539-x
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:Patients with either diabetes mellitus (DM) or metabolic syndrome (MS) are recognized as a high risk group for cardiovascular disease (CVD). Several studies have demonstrated the clinical value of MS for predicting additional CVD risk in the DM population, although the clinical significance remains debatable...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-98
更新日期：2014-09-12 00:00:00
abstract：BACKGROUND:Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected QT interval (QTc interval) is related to ventricular arrhythmias and CVD mortality and exhibits a h...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0268-3
更新日期：2017-09-11 00:00:00
abstract：BACKGROUND:Number of diabetic patients under public primary care in Hong Kong rose from 150,157 (2009) to 173,015 (2013). This study aimed to track the 5-year change of their outcomes and care standard after the introduction of quality enhancement programmes. METHODS:Longitudinal study was conducted on a group of diab...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0072-x
更新日期：2015-09-17 00:00:00
abstract：BACKGROUND:Type 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidn...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-016-0159-z
更新日期：2016-07-28 00:00:00
abstract：BACKGROUND:Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism. OBJECTIVE:The aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2) and correlate it with body fat distrib...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0226-0
更新日期：2017-04-24 00:00:00
