Abstract：
:Latin America is a fast-growing region that currently faces unique challenges in the treatment of all forms of diabetes mellitus. The burden of this disease will be even greater in the coming years due, in part, to the large proportion of young adults living in urban areas and engaging in unhealthy lifestyles. Unfortunately, the national health systems in Latin-American countries are unprepared and urgently need to reorganize their health care services to achieve diabetic therapeutic goals. Stem cell research is attracting increasing attention as a promising and fast-growing field in Latin America. As future healthcare systems will include the development of regenerative medicine through stem cell research, Latin America is urged to issue a call-to-action on stem cell research. Increased efforts are required in studies focused on stem cells for the treatment of diabetes. In this review, we aim to inform physicians, researchers, patients and funding sources about the advances in stem cell research for possible future applications in diabetes mellitus. Emerging studies are demonstrating the potential of stem cells for β cell differentiation and pancreatic regeneration. The major economic burden implicated in patients with diabetes complications suggests that stem cell research may relieve diabetic complications. Closer attention should be paid to stem cell research in the future as an alternative treatment for diabetes mellitus.
journal_name
Diabetol Metab Syndrjournal_title
Diabetology & metabolic syndromeauthors
Solis MA,Moreno Velásquez I,Correa R,Huang LLHdoi
10.1186/s13098-019-0415-0subject
Has Abstractpub_date
2019-02-18 00:00:00pages
20issn
1758-5996pii
415journal_volume
11pub_type
杂志文章,评审abstract：Background:Brazil is one of top 10 countries with the highest number of people with diabetes mellitus (DM), affecting 16.8 million peoples. It is estimated that 7.7 million people (20-79 years) in the country have not yet been diagnosed, representing an under-diagnosis rate of 46.0%. Herein we aimed to screen people fo...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00593-5
更新日期：2020-10-08 00:00:00
abstract：BACKGROUND:Dietary factors are important environmental factors associated with the prevalence of metabolic syndrome (MS). The objective of this study was to assess the habitual nutrient intakes of patients with MS. METHODS:A cross-sectional study included 103 patients (82 % women) with MS seen at the endocrinology out...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0147-3
更新日期：2016-04-14 00:00:00
abstract：Objective:Several controversial findings have been reported on treatment outcomes for diabetic stroke patients that received thrombolysis therapy in the hospital. We determined whether the association between telestroke technology, thrombolysis therapy and clinical risk factors in diabetic acute ischemic stroke may res...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0421-2
更新日期：2019-05-09 00:00:00
abstract：:Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancie...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-12
更新日期：2014-01-31 00:00:00
abstract：:This manuscript reports the Brazilian Diabetes Society Position Statement for insulin adjustments based on trend arrows observed in continuous glucose monitoring systems. The Brazilian Diabetes Society supports the utilization of trend arrows for insulin dose adjustments in patients with diabetes on basal-bolus insuli...
journal_title：Diabetology & metabolic syndrome
pub_type： 信件
doi：10.1186/s13098-020-00607-2
更新日期：2021-01-03 00:00:00
abstract：Background:The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms. Methods:Eighty-four consecutive type 2 diabetic patients with unstable angina (UA) were included from January 2018 to June 2018 to calculate calcification scores ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-019-0464-4
更新日期：2019-08-19 00:00:00
abstract：BACKGROUND:Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of alisk...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0282-5
更新日期：2017-10-13 00:00:00
abstract：BACKGROUND:Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes s...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章,评审
doi：10.1186/s13098-017-0256-7
更新日期：2017-07-21 00:00:00
abstract：BACKGROUND:An increase in the prevalence of obesity entails great expenditure for governments. Physical exercise is a powerful tool in the combat against obesity and obesity-associated diseases. This study sought to determine the effect of three different exercise protocols on metabolic syndrome and lipid peroxidation ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-3-35
更新日期：2011-12-19 00:00:00
abstract：BACKGROUND:Coronary artery disease (CAD) is a major cardiovascular complication in diabetic patients. Despite the significant association between obesity and diabetes, the majority of the diabetic subjects are not obese in an Asian population. This study evaluated the association between obesity and coronary artery dis...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-134
更新日期：2014-12-05 00:00:00
abstract：BACKGROUND:Diabetic retinopathy is the main cause of preventable blindness in the economically active population in western countries. Diabetic retinopathy screening is effective in preventing blindness and can be performed through various diagnostic methods. Our objective is to compare binocular indirect ophthalmoscop...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0110-8
更新日期：2015-12-21 00:00:00
abstract：BACKGROUND:Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. METHODS:Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00609-0
更新日期：2020-11-19 00:00:00
abstract：BACKGROUND:Diabetes treatment requires specialized multi-professional teams, supplies for blood glucose monitoring and training for self-injections of human insulin or insulin analogues. The State Health Secretariat of the Federal District (SHS-FD) has dispensed insulin analogues by means of clinical validated protocol...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0061-0
更新日期：2015-08-18 00:00:00
abstract：BACKGROUND:Many patients with chronic heart failure (CHF) are believed to have unrecognized diabetes, which is associated with a worse prognosis. This study aimed to describe glucose tolerance in a general stable CHF population and to identify determinants of glucose tolerance focusing on body composition and skeletal ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-44
更新日期：2014-03-27 00:00:00
abstract：UNLABELLED: BACKGROUND:Plant flavonoids are emerging as potent therapeutic drugs effective against a wide range of aging diseases particularly bone metabolic disorders. Morin (3,5,7,20,40-pentahydroxyflavone), a member of flavonols, is an important bioactive compound by interacting with nucleic acids, enzymes and prot...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-5-5
更新日期：2013-02-06 00:00:00
abstract：: Metabolic Syndrome (MS) increases the risk for Coronary Artery Disease, stroke and diabetes. MS is twice more common amongst South Asian immigrants in US compared to native Caucasians. There are no nationally representative studies on prevalence of MS from any of the South Asian countries. The present study aims to e...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-4-24
更新日期：2012-05-31 00:00:00
abstract：Background:In type I diabetes mellitus (T1DM) pancreatic β cells are destroyed. Treatment entails exogenous insulin administration and strict diet control, yet optimal glycemic control is hardly attainable. Islet transplant could be an alternative in patients with poor glycemic control, but inefficient islet purificati...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00573-9
更新日期：2020-08-05 00:00:00
abstract：: In recent decades, Diabetes Mellitus has become a severe and growing global public healthcare problem due to the increase of its prevalence, morbidity and mortality. Post-transplant diabetes mellitus (PTDM) is a complication which takes place after a solid organ transplant, and its incidence is widely variable, rangi...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-1-14
更新日期：2009-10-05 00:00:00
abstract：BACKGROUND:The clinical features of atherosclerotic lesions in ketosis-onset diabetes are largely absent. We aimed to compare the characteristics of lower limb atherosclerotic lesions among type 1, ketosis-onset and non-ketotic type 2 diabetes. METHODS:A cross-sectional study was performed in newly diagnosed Chinese p...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-71
更新日期：2014-06-03 00:00:00
abstract：BACKGROUND AND AIM:A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, ...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00606-3
更新日期：2020-11-12 00:00:00
abstract：Background:To investigate the association of low carbohydrate diet (LCD) score with the risk of type 2 diabetes among adults. Methods:This cohort study was conducted on 4356 healthy participants aged ≥ 19 years old, who were followed-up for a mean duration of 3 years within the framework of the Tehran Lipid and Glucos...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00596-2
更新日期：2020-10-07 00:00:00
abstract：BACKGROUND:Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to investigate the safety and efficacy of secondary prevention of cardiovascular diseases...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0272-7
更新日期：2017-09-19 00:00:00
abstract：BACKGROUND:Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin resistance. Diabetic patients have a higher frequency of the IRS-1 Gly972Arg variant and this polym...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0026-3
更新日期：2015-04-02 00:00:00
abstract：BACKGROUND:Number of diabetic patients under public primary care in Hong Kong rose from 150,157 (2009) to 173,015 (2013). This study aimed to track the 5-year change of their outcomes and care standard after the introduction of quality enhancement programmes. METHODS:Longitudinal study was conducted on a group of diab...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-015-0072-x
更新日期：2015-09-17 00:00:00
abstract：Background:Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0387-5
更新日期：2018-11-22 00:00:00
abstract：BACKGROUND:The objective was to evaluate the muscle glucose metabolism in rats fed a fructose-rich diet after fetal protein malnutrition, at rest and after acute physical exercise at maximal lactate steady-state intensity. METHODS:The male offspring born of mothers fed on a balanced or low-protein diet were split in f...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/1758-5996-6-118
更新日期：2014-11-06 00:00:00
abstract：Background:Diabetic nephropathy (DN) is a severe complication of diabetes with type 1 and 2. Long non-coding RNAs (lncRNAs) are being found to be involved in the DN pathogenesis. In this study, we aimed to further explore the effect and underlying mechanism of plasmacytoma variant translocation 1 (PVT1) in DN pathogene...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-020-00539-x
更新日期：2020-04-15 00:00:00
abstract：OBJECTIVE:To translate and validate the instrument Diabetes Self-Management Profile (DSMP)-Conventional and Flexible Regimens into Brazilian Portuguese language in order to evaluate the quality of diabetes self-management in children and adolescents with type 1 diabetes and their caregivers. METHODS:DSMP was submitted...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-017-0250-0
更新日期：2017-07-11 00:00:00
abstract：BACKGROUND:Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where the prevalence of MetS are on the rise. METHODS:In this cross-sectional study, a total of 509 rando...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-016-0134-8
更新日期：2016-03-08 00:00:00
abstract：Background:Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-...
journal_title：Diabetology & metabolic syndrome
pub_type： 杂志文章
doi：10.1186/s13098-018-0330-9
更新日期：2018-04-10 00:00:00
