当前位置： SCI文献检索 > Diabetology & Metabolic Syndrome期刊下所有文献 > Differential association between obesity and coronary artery disease according to the presence of diabetes in a Korean population.

Differential association between obesity and coronary artery disease according to the presence of diabetes in a Korean population.

Abstract：

BACKGROUND:Coronary artery disease (CAD) is a major cardiovascular complication in diabetic patients. Despite the significant association between obesity and diabetes, the majority of the diabetic subjects are not obese in an Asian population. This study evaluated the association between obesity and coronary artery disease (CAD) according to the diabetes status in a Korean population. METHODS:The association between obesity and CAD using the parameters of any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to the presence of diabetes was evaluated in 7,234 Korean adults who underwent multi-detector computed tomography for general health evaluations. Obesity was defined as a body mass index (BMI) ≥25 kg/m(2). RESULTS:The prevalence of obesity was significantly higher in diabetic subjects than in non-diabetic subjects, but the majority of the diabetic subjects were non-obese (48% vs. 37%, p <0.001). The incidence of any plaque (58% vs. 29%), obstructive plaque (20% vs. 6%), and CACS >100 (20% vs. 6%) were significantly higher in diabetic patients than in non-diabetic subjects (p <0.001, respectively). Incidence of any plaque (33% vs. 26%, p <0.001), obstructive plaque (7% vs. 6%, p = 0.014), and CACS >100 (8% vs. 6%, p = 0.002) was significantly higher in non-diabetic subjects with obesity than in those without obesity, but the incidence of all coronary parameters was not different in diabetic subjects according to the obesity status. After adjusting for confounding risk factors including age, gender, hypertension, dyslipidemia, current smoking, and mild renal dysfunction, obesity was independently associated with increased risks of any plaque (OR 1.14) and CACS >100 (OR 1.31) only in non-diabetic subjects (p <0.05, respectively). Multiple logistic regression models revealed that diabetes was independently associated with all coronary parameters. CONCLUSION:Despite a significantly higher prevalence of obesity in diabetic subjects than in non-diabetic subjects, obesity is associated with the presence of any plaque and severe coronary calcification only in subjects without established diabetes among Korean population.

journal_name

Diabetol Metab Syndr

journal_title

Diabetology & metabolic syndrome

authors

Won KB,Chang HJ,Niinuma H,Sung J,Cho IJ,Shim CY,Hong GR,Kim YJ,Choi BW,Chung N

doi

10.1186/1758-5996-6-134

subject

Has Abstract

pub_date

2014-12-05 00:00:00

pages

134

issue

issn

1758-5996

pii

389

journal_volume

pub_type

杂志文章

在线工具

Differential association between obesity and coronary artery disease according to the presence of diabetes in a Korean population.