Abstract：
BACKGROUND:As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in insulin secretion, insulin sensitivity, and glucose metabolism, the present study was conducted to investigate the role of PRX3 in the pathogenesis of polycystic ovarian syndrome (PCOS) featured in insulin resistance. METHODS:Enzyme-linked immunosorbent assay was performed to detect plasma PRX3 in PCOS patients and control subjects. Levels of reactive oxygen species (ROS) and oxidized PRXs were detected in mouse islet cells treated with gradient glucose. RESULTS:We did not find significant difference of fasting plasma PRX3 between PCOS patients and controls. No association was noticed between fasting plasma PRX3 and fasting plasma glucose or insulin. After oral glucose tolerance test (OGTT), PCOS patients showed higher levels of both glucose and insulin as compared to controls. The plasma level of PRX3 was significantly increased at 2 h and began to fall back at 3 h of OGTT. There was a one-hour time lag of peak values between plasma PRX3 and insulin, and the plasma PRX3 at 2 h was positively correlated with the insulin level at 1 h of OGTT of PCOS patients. In addition, the level of ROS was significantly elevated at 1 h and oxidized PRX3 was increased dramatically at 2 h of 16.7mM glucose stimulation in mouse islet cells. CONCLUSION:It seems that PRX3 does not show its antioxidant function under baseline conditions. Instead, PRX3 responds to oxidative stress induced by rapid increase of insulin and glucose in patients with PCOS.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Liu HL,Li TT,Yu AQ,Li J,Li X,Li L,Kaifu Tdoi
10.1186/s12902-019-0358-3subject
Has Abstractpub_date
2019-03-14 00:00:00pages
32issue
1issn
1472-6823pii
10.1186/s12902-019-0358-3journal_volume
19pub_type
杂志文章abstract：BACKGROUND:The aim of this study is to perform a cost-effectiveness comparison between palpation-guided thyroid fine-needle aspiration biopsies (P-FNA) and ultrasound-guided thyroid FNA biopsies (USG-FNA). METHODS:Each nodule was considered as a case. Diagnostic steps were history and physical examination, TSH measure...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-9-14
更新日期：2009-05-16 00:00:00
abstract：BACKGROUND:Whether lower dose cabergoline therapy for hyperprolactinemia increases risk of valvular dysfunction remains controversial. We examined valvular abnormalities among asymptomatic adults with hyperprolactinemia treated with dopamine agonists. METHODS:This cross-sectional study was conducted among adults recei...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-0507-8
更新日期：2020-02-19 00:00:00
abstract：UNLABELLED: BACKGROUND:Severe hypoglycaemia (SH) is one of the most feared complications of type 1 diabetes (T1DM) with a reported prevalence of nearly 40%. In randomized trials of Multiple Daily Injections (MDI) and Continuous Subcutaneous Insulin Infusion (CSII) therapy there is a possible benefit of CSII in reducin...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-33
更新日期：2012-12-13 00:00:00
abstract：BACGROUND:To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. METHODS:138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; g...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0025-2
更新日期：2015-06-20 00:00:00
abstract：BACKGROUND:Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from T...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-018-0238-2
更新日期：2018-02-13 00:00:00
abstract：:BACKGROUND: The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested. METHODS: Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured islets isol...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-1-1
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations possibly due to genetic, environmental or analytical issues. Despite the importance of RIs, globally th...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0107-9
更新日期：2016-05-23 00:00:00
abstract：BACKGROUND:There have only been a few reports about use of dipeptidyl peptidase 4 (DPP-4) inhibitors in elderly patients with type 2 diabetes mellitus (T2DM), suggesting that the safety of these agents has not been sufficiently demonstrated. We performed a comparative review of the efficacy and safety of sitagliptin fo...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0033-2
更新日期：2015-07-03 00:00:00
abstract：BACKGROUND:The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS. METHODS:We conducted...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0061-y
更新日期：2015-11-04 00:00:00
abstract：BACKGROUND:Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor obstetric care and scarcity of diagnostic and therapeutic r...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-4
更新日期：2012-07-10 00:00:00
abstract：BACKGROUND:The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS:We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12902-017-0209-z
更新日期：2017-10-03 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder, and its pathogenesis is still under debate. Trimethylamine-N-oxide (TMAO) is a small, organic compound generated by the gut microbiome with a hypothesized relation to insulin resistance (IR) and low-grade inflammation in PCOS. By compar...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0486-9
更新日期：2020-01-06 00:00:00
abstract：UNLABELLED: BACKGROUND:Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatment is intensified. METHODS:DiaRegis is a prospective German registry that follows 3810 ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-23
更新日期：2012-10-17 00:00:00
abstract：BACKGROUND:Telomeres are DNA repeat sequences necessary for DNA replication which shorten at cell division at a rate directly related to levels of oxidative stress. Critical telomere shortening predisposes to cell senescence and to epithelial malignancies. Type 2 diabetes is characterised by increased oxidative DNA dam...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-8-12
更新日期：2008-10-10 00:00:00
abstract：BACKGROUND:Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0129-3
更新日期：2016-09-09 00:00:00
abstract：BACKGROUND:Most of the patients with type 1 and V hyperlipoproteinemia (HLP) present with symptoms and signs of acute pancreatitis due to marked elevation of triglycerides, but this baby presented with a chest infection, which was later diagnosed as type V HLP on laboratory workup. CASE PRESENTATION:We report a case o...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-0502-0
更新日期：2020-02-11 00:00:00
abstract：BACKGROUND:Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in peripheral blood mononuclear cells (PBMCs) to see if these cells can be used to study these anti-inf...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-9-8
更新日期：2009-02-25 00:00:00
abstract：BACKGROUND:Pituitary metastasis is a rare condition with a poor prognosis. Very few patients with pituitary metastasis are symptomatic. It is often associated with presence of co-existing metastases to other organs. Isolated pituitary metastasis as the first presentation of primary malignancy is uncommon. CASE PRESENT...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,评审
doi：10.1186/s12902-019-0445-5
更新日期：2019-10-29 00:00:00
abstract：BACKGROUND:As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12902-019-0347-6
更新日期：2019-02-13 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS:This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participa...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-24
更新日期：2014-03-08 00:00:00
abstract：BACKGROUND:Previous studies have shown inconsistent results about the usefulness of bilateral inferior petrosal sinus sampling (BIPSS) in differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome. This meta-analysis evaluated the diagnostic value of BIPSS via the published literature. MET...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00623-3
更新日期：2020-09-17 00:00:00
abstract：BACKGROUND:Among patients with type 2 diabetes, insulin intensification to achieve glycemic targets occurs less often than clinically indicated. Barriers to intensification are not well understood. We present patients' baseline characteristics from MOSAIc, a study investigating patient-, physician-, and healthcare envi...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/s12902-015-0044-z
更新日期：2015-09-09 00:00:00
abstract：BACKGROUND:Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS:Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n =...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0424-x
更新日期：2019-09-02 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amo...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-0534-5
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0068-4
更新日期：2015-12-03 00:00:00
abstract：BACKGROUND:Autoimmune hypophysitis is a rare disease characterized by the infiltration of lymphocytic cells into the pituitary gland. 18F-fluorodeoxyglucose (FDG) and 18F-2-fluorodeoxy sorbitol (FDS) positron emission tomography (PET) are well-established and emerging techniques, respectively, which may aid in the diag...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00567-8
更新日期：2020-06-09 00:00:00
abstract：BACKGROUND:Thyrotoxicosis is often caused by destructive thyroiditis (DT) or Graves' disease (GD), and a prompt and accurate differential diagnosis for thyrotoxicosis is needed as management strategy differs. A meta-analysis of published literature was performed to evaluate the diagnostic accuracy for differentiating G...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12902-019-0388-x
更新日期：2019-06-06 00:00:00
abstract：BACKGROUND:Previous studies have shown the negative impact of sleep disturbances, specifically insomnia symptoms, on glucose metabolism for people with type 2 diabetes (T2D). People with insomnia symptoms are at risk of poor glycemic control and suboptimal diabetes self-care behavior (DSCB). Investigating the impact of...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00612-6
更新日期：2020-09-05 00:00:00
abstract：BACKGROUND:We report the case of a patient who had a non-functional metastatic pancreatic neuroendocrine tumour (pNET), which changed in functionality during the course of the disease. This case demonstrates the effectiveness of conventional cytotoxic chemotherapy in the management of select group of patients with this...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-70
更新日期：2014-08-24 00:00:00
abstract：BACKGROUND:11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician's diagnosis of remitting diabetes. Our aim was to identify patients with remitting diabetes whose clinical presentation is not explained by any known aetiology of diabetes....
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-45
更新日期：2014-06-09 00:00:00
