Abstract:
BACKGROUND:The aim of this study is to perform a cost-effectiveness comparison between palpation-guided thyroid fine-needle aspiration biopsies (P-FNA) and ultrasound-guided thyroid FNA biopsies (USG-FNA). METHODS:Each nodule was considered as a case. Diagnostic steps were history and physical examination, TSH measurement, Tc99m thyroid scintigraphy for nodules with a low TSH level, initial P-FNA versus initial USG-FNA, repeat USG-FNA for nodules with initial inadequate P-FNA or USG-FNA, hemithyroidectomy for inadequate repeat USG-FNA. American Thyroid Association thyroid nodule management guidelines were simulated in estimating the cost of P-FNA strategy. American Association of Clinical Endocrinologists guidelines were simulated for USG-FNA strategy. Total costs were estimated by adding the cost of each diagnostic step to reach a diagnosis for 100 nodules. Strategy cost was found by dividing the total cost to 100. Incremental cost-effectiveness ratio (ICER) was calculated by dividing the difference between strategy cost of USG-FNA and P-FNA to the difference between accuracy of USG-FNA and P-FNA. A positive ICER indicates more and a negative ICER indicates less expense to achieve one more additional accurate diagnosis of thyroid cancer for USG-FNA. RESULTS:Seventy-eight P-FNAs and 190 USG-FNAs were performed between April 2003 and May 2008. There were no differences in age, gender, thyroid function, frequency of multinodular goiter, nodule location and diameter (median nodule diameter: 18.4 mm in P-FNA and 17.0 mm in USG-FNA) between groups. Cytology results in P-FNA versus USG-FNA groups were as follows: benign 49% versus 62% (p = 0.04), inadequate 42% versus 29% (p = 0.03), malignant 3% (p = 1.00) and indeterminate 6% (p = 0.78) for both. Eleven nodules from P-FNA and 18 from USG-FNA group underwent surgery. The accuracy of P-FNA was 0.64 and USG-FNA 0.72. Unit cost of P-FNA was 148 Euros and USG-FNA 226 Euros. The cost of P-FNA strategy was 534 Euros and USG-FNA strategy 523 Euros. Strategy cost includes the expense of repeat USG-FNA for initial inadequate FNAs and surgery for repeat inadequate USG-FNAs. ICER was -138 Euros. CONCLUSION:Universal application of USG-FNA for all thyroid nodules is cost-effective and saves 138 Euros per additional accurate diagnosis of benign versus malignant thyroid nodular disease. TRIAL REGISTRATION:ClinicalTrials.gov, NCT00571090.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Can ASdoi
10.1186/1472-6823-9-14subject
Has Abstractpub_date
2009-05-16 00:00:00pages
14issn
1472-6823pii
1472-6823-9-14journal_volume
9pub_type
杂志文章abstract:UNLABELLED: BACKGROUND:The use of chromium supplements is widespread for the prevention and treatment of diabetes mellitus but there are conflicting reports on efficacy, possibly reflecting discrepant effects across different populations. In the present studies, we test the hypothesis that chromium supplementation rai...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-31
更新日期:2012-11-30 00:00:00
abstract:BACKGROUND:The hormone somatostatin inhibits growth hormone release from the pituitary gland and is theoretically linked to diabetes and diabetes related complications. This study aimed to investigate the relationship between levels of the stable somatostatin precursor, N-terminal prosomatostatin (NT-proSST), with mort...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-015-0009-2
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-11-7
更新日期:2011-03-22 00:00:00
abstract:BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-1
更新日期:2014-01-02 00:00:00
abstract:BACKGROUND:Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relationship with PTHrP has not been determined or studied.The aim of this study is to describe and discu...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-32
更新日期:2014-04-10 00:00:00
abstract:BACKGROUND:In primary health care systems where member's turnover is relatively low, the question, whether investment in quality of care improvement can make a business case, or is cost effective, has not been fully answered.The objectives of this study were: (1) to investigate the relationship between improvement in s...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-92
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population. METHODS:The study was based on a cross-sectional analysis of data fr...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0479-8
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:Parathyroid carcinoma is a rare neoplasm that may present sporadically or in the context of a genetic syndrome. Diagnosis and management are challenging due to the lack of clinical and pathological features that may reliably distinguish malignant from benign disease. METHODS:From January 2013 to December 20...
journal_title:BMC endocrine disorders
pub_type: 临床试验,杂志文章
doi:10.1186/s12902-019-0368-1
更新日期:2019-05-29 00:00:00
abstract:BACKGROUND:Diabetes self-management education can be helpful for patients with type 2 diabetes in managing their condition. We aimed to study the effects of the group-based PRoactive Interdisciplinary Self-MAnagement (PRISMA) training program on self-reported and clinical outcomes in patients with type 2 diabetes treat...
journal_title:BMC endocrine disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12902-019-0466-0
更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and fr...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-017-0201-7
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-015-0063-9
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:To estimate the proportion of diabetic patients (DPts) with peripheral vascular disease treated at a primary health care site after an endocrinologist-based intervention, who meet ATP III and Steno targets of metabolic control, as well as to compare the outcome with the results of the patients treated by end...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-8-9
更新日期:2008-07-31 00:00:00
abstract:BACKGROUND:Insulin resistance and diabetes are associated with increased oxidative stress and impairment of cellular defence systems. Our purpose was to investigate the interaction between glucose metabolism, antioxidative capacity and heat shock protein (HSP) defence in different skeletal muscle phenotypes among middl...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-8-3
更新日期:2008-03-27 00:00:00
abstract:BACKGROUND:The pathophysiology of type2 diabetes involves both insulin resistance and poor beta cell function. Studies have been done in several populations to assess the relative importance of these mechanisms in individual patients. In our environment studies to assess beta cell function have been done with glucagon ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-11
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for goitre among schoolchildren in South Tajikistan. METHODS:Ten primary schools in four districts in ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-50
更新日期:2013-11-02 00:00:00
abstract:BACKGROUND:Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the 'real-world' medication utilization patterns for patients with type 2 diabetes initiating exenatide BID or glargine. The objective of this study was...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-20
更新日期:2013-06-22 00:00:00
abstract:BACKGROUND:Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and is characterized by the presence of insulin autoantibodies. Patients with IAS usually complain of hypoglycemia without any previous insulin received. Glucocorticoids and immunosuppressants are used to treat IAS. CASE PRESENTATION:We repor...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0482-0
更新日期:2019-12-28 00:00:00
abstract:BACKGROUND:Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by mutations in the zinc finger transcription factor gene, GATA3. GATA3 has 2 zinc finger domains, which play an important role in the increase in target gene transcription activity. CASE PRESENTATI...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-015-0065-7
更新日期:2015-10-30 00:00:00
abstract:BACKGROUND:Several studies have shown the association of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 with type 2 diabetes (T2D). However, the association of alternative variants and haplotypes of SLC30A8 with T2D have not been studied in different populations. The aim of this study is to a...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-2
更新日期:2014-01-06 00:00:00
abstract:BACKGROUND:This study tested the association between serum levels of microRNA-486, -146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM). METHODS:the study included 120 children; divided into three groups: G1 (50 healthy), G2 (35 obese) and G3 (35 obese with T2DM). Th...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00628-y
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in insulin secretion, insulin sensitivity, and glucose metabolism, the present study was conducted to ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0358-3
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:Clinical determination of mid-parental height is an important part of the assessment of a child's growth, however our clinical impression has been that parents cannot be relied upon to accurately report their own heights. Therefore, we conducted this study to assess the accuracy of parental height self-repor...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-7-2
更新日期:2007-04-02 00:00:00
abstract:BACKGROUND:Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals. METHODS:We conducted a cross-se...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-36
更新日期:2013-09-29 00:00:00
abstract::Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT system is synthesized in the rat and human heart. The direct myocardial infusion with OT into an ischemic or failing heart has the potential to elicit a variety of cardioprotective effects. OT treatment attenuates cardiomyocyte (C...
journal_title:BMC endocrine disorders
pub_type: 杂志文章,评审
doi:10.1186/s12902-016-0110-1
更新日期:2016-06-07 00:00:00
abstract:BACKGROUND:Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons' quality of life is not adequately elucidated. The purpose of this study was to compare the Health-Related Quality of Life (HRQOL) of persons with pre-diabetes with...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-018-0261-3
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mell...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00661-x
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor obstetric care and scarcity of diagnostic and therapeutic r...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-4
更新日期:2012-07-10 00:00:00
abstract:BACKGROUND:Sympathetic activity and insulin resistance have recently been linked with chronic tendon and musculoskeletal pain. Polycystic ovarian syndrome is linked with insulin resistance and increased sympathetic drive and was therefore an appropriate condition to study the effects of modulating sympathetic activity ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00610-8
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS:Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n =...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0424-x
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:The major cause of primary hypothyroidism is autoimmune mediated with progressive and permanent destruction of the thyroid gland resulting in life-long replacement therapy. Treatable and reversible hypothyroidism is unusual and here forth is such a case due to infection of the thyroid gland with Tropheryma w...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-6-3
更新日期:2006-05-10 00:00:00