Abstract:
BACKGROUND:There have only been a few reports about use of dipeptidyl peptidase 4 (DPP-4) inhibitors in elderly patients with type 2 diabetes mellitus (T2DM), suggesting that the safety of these agents has not been sufficiently demonstrated. We performed a comparative review of the efficacy and safety of sitagliptin for Japanese patients with T2DM managed in the real-world clinical setting. METHODS:An age-stratified analysis was performed of 831 patients who were treated with sitagliptin for 2 years. Parameters assessed included the hemoglobin A1c (HbA1c), body weight, serum creatinine, and adverse events. HbA1c and the incidence of hypoglycemia were also evaluated in patients treated with sitagliptin and a sulfonylurea (SU), who were divided into three age groups (<65 years, 65-74 years, and ≥75 years). RESULTS:Comparison of glycemic control parameters, laboratory values, and adverse events revealed significant improvement of HbA1c, casual postprandial plasma glucose, and fasting plasma glucose in each age group with no change in body weight. Serum creatinine increased significantly in all age groups. Hypoglycemia only occurred in patients who received combined treatment with an SU and sitagliptin, and there was no age-related difference in its incidence. CONCLUSIONS:HbA1c was improved by 2 years of sitagliptin therapy in all three age groups, and age did not seem to influence the incidence of hypoglycemic events. These results confirm the efficacy and safety of sitagliptin in patients ≥ 75 years old, suggesting that it is also useful for treating elderly patients with T2DM.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Umezawa S,Kubota A,Maeda H,Kanamori A,Matoba K,Jin Y,Minagawa F,Obana M,Iemitsu K,Ito S,Amamiya H,Kaneshiro M,Takai M,Kaneshige H,Hoshino K,Ishikawa M,Minami N,Takuma T,Sasai N,Aoyagi S,Kawata T,Mokubo A,Miyaidoi
10.1186/s12902-015-0033-2subject
Has Abstractpub_date
2015-07-03 00:00:00pages
34issn
1472-6823pii
10.1186/s12902-015-0033-2journal_volume
15pub_type
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