Abstract:
BACKGROUND:Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of glucose homeostasis and xenobiotic and lipid metabolism and is affected by insulin signaling. The precise transcriptional profiling of the type-1 diabetic liver and its comparison to aging have not been elucidated yet. METHODS:Here, we studied the differential genomic expression of mouse liver cells under adult hyperglycemic and aged normoglycemic conditions using expression arrays. RESULTS:Differential gene expression involved in an increase in glucose and impaired lipid metabolism were detected in the type-1 diabetic liver. In this regard, Ppargc1a presents an increased expression and is a key gene that might be regulating both processes. The differential gene expression observed may also be associated with hepatic steatosis in diabetic mouse liver, as a secondary disease. Similarly, middle-aged mice presented differential expression of genes involved in glucose, lipid and xenobiotic metabolism. These genes could be associated with an increase in polyploidy, but the consequences of differential expression were not as drastic as those observed in diabetic animals. CONCLUSIONS:Taken together, these findings provide new insights into gene expression profile changes in type-1 diabetic liver. Ppargc1a was found to be the key-gene that increases glucose metabolism and impairs lipid metabolism impairment. The novel results reported here open new areas of investigation in diabetic research and facilitate the development of new strategies for gene therapy.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Ghiraldini FG,Silveira AB,Kleinjan DA,Gilbert N,Mello MLdoi
10.1186/1472-6823-14-19subject
Has Abstractpub_date
2014-03-03 00:00:00pages
19issn
1472-6823pii
1472-6823-14-19journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Vitamin D deficiency is pandemic while resources available to measure 25-hydroxyvitamin D (25OHD) are limited. The present study aimed to verify whether sun exposure measured by a structured questionnaire could predict serum 25OHD concentrations in healthy Caucasian individuals living in a tropical area. ME...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
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更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine defic...
journal_title:BMC endocrine disorders
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pub_type: 杂志文章
doi:10.1186/1472-6823-13-41
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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