Abstract：
:BACKGROUND: The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested. METHODS: Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured islets isolated from normal rats. Incubated islets were also used to measure CAs release in the presence of low and high glucose, and the effect of alpha2-(yohimbine [Y] and idazoxan [I]) and alpha1-adrenergic antagonists (prazosin [P] and terazosin [T]) upon insulin secretion elicited by high glucose. RESULTS: Fresh islets incubated with 16.7 mM glucose released significantly more insulin in the presence of 1 &mgr;M MIT (6.66 +/- 0.39 vs 5.01 +/- 0.43 ng/islet/h, p < 0.02), but did not affect significantly the insulin response to low glucose. A similar enhancing effect of MIT upon insulin secretion was obtained using precultured islets devoid of neural cells, but absolute values were lower than those from fresh islets, suggesting that MIT inhibits islet rather than neural tyrosine hydroxylase. CAs concentration in the incubation media of fresh isolated islets was significantly higher in the presence of 16.7 than 3.3 mM glucose: dopamine 1.67 +/- 0.13 vs 0.69 +/- 0.13 pg/islet/h, p < 0.001, and noradrenaline 1.25 +/- 0.17 vs 0.49 +/- 0.04 pg/islet/h, p < 0.02. Y and I enhanced the release of insulin elicited by 16.7 mM glucose while P and T decreased such secretion. CONCLUSION: Our results suggest that islet-originated CAs directly modulate insulin release in a paracrine manner.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Borelli MI,Gagliardino JJdoi
10.1186/1472-6823-1-1keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
1issue
1issn
1472-6823journal_volume
1pub_type
杂志文章abstract：BACKGROUND:Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS:Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n =...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0424-x
更新日期：2019-09-02 00:00:00
abstract：BACKGROUND:Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for goitre among schoolchildren in South Tajikistan. METHODS:Ten primary schools in four districts in ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-13-50
更新日期：2013-11-02 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0063-9
更新日期：2015-10-29 00:00:00
abstract：:ABSTRACT : BACKGROUND : The combination of transfusion and chelation therapy has dramatically extended the life expectancy of thalassemic patients. The main objective of this study is to determine the prevalence of prominent thalassemia complications. METHODS : Two hundred twenty patients entered the study. Physicians...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-3-4
更新日期：2003-08-12 00:00:00
abstract：BACKGROUND:Chronic insulin resistance, exacerbated in the course of pregnancy, is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). We hypothesise that the degree of insulin resistance, assessed at diagnosis of GDM, is a parameter of its pathophysiologic heterogeneity and/or severity. Thus...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-13-21
更新日期：2013-07-02 00:00:00
abstract：BACKGROUND:To evaluate the impact of treatment with recombinant human growth hormone (rhGH; Omnitrope®) on the risk of diabetes mellitus in adults with growth hormone deficiency (GHD), using data from the ongoing PATRO Adults post-marketing surveillance study. METHODS:PATRO Adults is an ongoing post-marketing surveill...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0464-2
更新日期：2019-12-11 00:00:00
abstract：BACKGROUND:A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown. This study aimed to investigate the relationship between circulating neutrophils and DKD...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00597-2
更新日期：2020-10-22 00:00:00
abstract：BACKGROUND:In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations possibly due to genetic, environmental or analytical issues. Despite the importance of RIs, globally th...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0107-9
更新日期：2016-05-23 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect. CASE PRESENTATION:A 56-year old female presented with hypercalcaemia of 3.38 mmol/L (2.2-2.65 mmol/L) and a history of breast cancer....
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-0532-7
更新日期：2020-04-20 00:00:00
abstract：BACKGROUND:Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relationship with PTHrP has not been determined or studied.The aim of this study is to describe and discu...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-32
更新日期：2014-04-10 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient's quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in pa...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12902-015-0052-z
更新日期：2015-10-12 00:00:00
abstract：BACKGROUND:Primary care physicians (PCPs) are the main providers of diabetes care especially in resource-limited countries which experience extreme shortage of specialists. The present study aimed to evaluate PCPs' approach towards diabetes mellitus (DM) diagnosis, evaluation and management in Cameroon. METHODS:We car...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0016-3
更新日期：2015-04-04 00:00:00
abstract：BACKGROUND:Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation. CASE PRESENTATION:We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extr...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-017-0186-2
更新日期：2017-06-21 00:00:00
abstract：BACKGROUND:Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It is essential to establish the frequency of amputations in people with diabetes after any change to the management of diabetic foot care. The present study aim to compare the frequency of lower-extremity...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0111-0
更新日期：2016-07-07 00:00:00
abstract：BACKGROUND:Most of the patients with type 1 and V hyperlipoproteinemia (HLP) present with symptoms and signs of acute pancreatitis due to marked elevation of triglycerides, but this baby presented with a chest infection, which was later diagnosed as type V HLP on laboratory workup. CASE PRESENTATION:We report a case o...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-0502-0
更新日期：2020-02-11 00:00:00
abstract：BACKGROUND:The prevalence of type 2 diabetes mellitus (T2DM) is expected to increase from 7.7% in 2017 to 8.4% in 2045 worldwide. Diabetes complications contribute to morbidity and mortality. To evaluate whether the diabetes complications severity index (DCSI) was associated with increased risks of mortality and hospit...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00605-5
更新日期：2020-08-10 00:00:00
abstract：BACKGROUND:11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician's diagnosis of remitting diabetes. Our aim was to identify patients with remitting diabetes whose clinical presentation is not explained by any known aetiology of diabetes....
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-45
更新日期：2014-06-09 00:00:00
abstract：AIM:To assess the factors associated with antihyperglycaemic medication initiation in UK patients with newly diagnosed type 2 diabetes. METHODS:In a retrospective cohort study, patients with newly diagnosed type 2 diabetes were identified during the index period of 2003-2005. Eligible patients were ≥ 30 years old at t...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-1
更新日期：2012-03-07 00:00:00
abstract：BACKGROUND:Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by mutations in the zinc finger transcription factor gene, GATA3. GATA3 has 2 zinc finger domains, which play an important role in the increase in target gene transcription activity. CASE PRESENTATI...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0065-7
更新日期：2015-10-30 00:00:00
abstract：BACKGROUND:Thyrotoxicosis is often caused by destructive thyroiditis (DT) or Graves' disease (GD), and a prompt and accurate differential diagnosis for thyrotoxicosis is needed as management strategy differs. A meta-analysis of published literature was performed to evaluate the diagnostic accuracy for differentiating G...
journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12902-019-0388-x
更新日期：2019-06-06 00:00:00
abstract：BACKGROUND:Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0129-3
更新日期：2016-09-09 00:00:00
abstract：BACKGROUND:Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-11-7
更新日期：2011-03-22 00:00:00
abstract：BACKGROUND:Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mell...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00661-x
更新日期：2020-12-09 00:00:00
abstract：BACKGROUND:The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS:The study included 1482 sub...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-018-0232-8
更新日期：2018-01-27 00:00:00
abstract：BACKGROUND:Islet cell transplantation is a method to stabilize type 1 diabetes patients with hypoglycemia unawareness and unstable blood glucose levels by reducing insulin dependency and protecting against severe hypoglycemia through restoring endogenous insulin secretion. This study analyses the current cost-effective...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-016-0097-7
更新日期：2016-04-09 00:00:00
abstract：BACKGROUND:Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor obstetric care and scarcity of diagnostic and therapeutic r...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-4
更新日期：2012-07-10 00:00:00
abstract：BACKGROUND:Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. METHODS:We investigated the association b...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0481-1
更新日期：2020-01-06 00:00:00
abstract：UNLABELLED: BACKGROUND:Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatment is intensified. METHODS:DiaRegis is a prospective German registry that follows 3810 ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-23
更新日期：2012-10-17 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder, and its pathogenesis is still under debate. Trimethylamine-N-oxide (TMAO) is a small, organic compound generated by the gut microbiome with a hypothesized relation to insulin resistance (IR) and low-grade inflammation in PCOS. By compar...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-019-0486-9
更新日期：2020-01-06 00:00:00
abstract：BACKGROUND:Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. METHODS:In 2001-2004, 1811 men and women (30-75 years) were randomly selected fro...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-9-16
更新日期：2009-06-21 00:00:00
