Abstract:
BACKGROUND:Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It is essential to establish the frequency of amputations in people with diabetes after any change to the management of diabetic foot care. The present study aim to compare the frequency of lower-extremity amputations in patients with diabetes foot ulcer over a ten-year period. METHODS:Six hundred forty eight patients with diabetes foot ulcer were retrospectively studied from 2004 to 2013. The clinical features, laboratory results and the lower-extremity amputations were recorded. Major amputation was defined as amputations above the ankle while minor amputation was amputations below the ankle in the present study. RESULTS:Patients with diabetic foot ulcer were old (age 66.96 ± 11.96 years), with a long duration of diabetes (10.30 ± 6.94 years), high HbA1c (9.19 ± 2.62 %), SBP (144.05 ± 24.18 mmHg), DBP (79.53 ± 11.88 mmHg), LDL-C (2.71 ± 0.93 mmol/L) and had great frequency of neuropathy (62.7 %), retinopathy (45.0 %), nephropathy (39.5 %) and PAD (33.2 %). From 2004 to 2013, the frequency of all lower-extremity amputations is 12.0 % (5.2 % major amputation, 6.8 % minor amputation). The frequency of major amputations decreased from 9.5 % in 2004 and 14.5 % in 2005 to less than 5.0 % after 2006. In particular, there was a significant decline in major amputations of diabetic foot patient with Wagner 3 to 4 wounds. The frequency rate of major amputations in diabetic foot patient with Wagner 3 to 4 wounds fell from 35.7 % in 2004 to 4.4 % after 2007. The change in frequency of minor amputations was fluctuation. CONCLUSION:This study demonstrates that the introduction of a multidisciplinary team, coordinated by an endocrinologist and a podiatrist, for managing diabetic foot disease is associated with a reduction in the frequency of major amputations in patients with diabetes.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Wang C,Mai L,Yang C,Liu D,Sun K,Song W,Luo B,Li Y,Xu M,Zhang S,Li F,Ren M,Yan Ldoi
10.1186/s12902-016-0111-0subject
Has Abstractpub_date
2016-07-07 00:00:00pages
38issue
1issn
1472-6823pii
10.1186/s12902-016-0111-0journal_volume
16pub_type
杂志文章abstract:BACKGROUND:The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS:We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of...
journal_title:BMC endocrine disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12902-017-0209-z
更新日期:2017-10-03 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient's quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in pa...
journal_title:BMC endocrine disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12902-015-0052-z
更新日期:2015-10-12 00:00:00
abstract:BACKGROUND:Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. METHODS:In this study DLG1-AS1 and miR-199a-3p in plasma of both PT...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0440-x
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:The detection of microvascular damage in type 1 diabetes is difficult and traditional investigations do not detect changes until they are well established. The purpose of this study was to investigate the combined ability of nailfold capillaroscopy, laser Doppler flowmetry, retinal vessel analysis and 24-hr ...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-41
更新日期:2013-10-05 00:00:00
abstract:BACKGROUND:We report a novel mutation within the StAR gene, causing congenital adrenal hyperplasia, with the so far unreported association with heterochromia iridis. CASE PRESENTATION:In a now 15-year-old girl (born at 41 + 6 weeks of gestation) adrenal failure was diagnosed in the neonatal period based on the clinica...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0448-2
更新日期:2019-10-30 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-11
更新日期:2012-06-27 00:00:00
abstract:UNLABELLED: BACKGROUND:Severe hypoglycaemia (SH) is one of the most feared complications of type 1 diabetes (T1DM) with a reported prevalence of nearly 40%. In randomized trials of Multiple Daily Injections (MDI) and Continuous Subcutaneous Insulin Infusion (CSII) therapy there is a possible benefit of CSII in reducin...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-33
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-1
更新日期:2014-01-02 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-018-0261-3
更新日期:2018-05-29 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-018-0246-2
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Caloric restriction is an effective way to treat Type 2 diabetes (T2D). However, chronic and severe restriction of food intake is difficult to sustain and is known to promote slower metabolism. Intermittent and frequent fasting can exert similar metabolic effects, but may be even more challenging for most pa...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00576-7
更新日期:2020-06-24 00:00:00
abstract:BACKGROUND:We investigated the association between sleep symptoms, which cause sleep disorder, and quality of life (QoL) among people with type 2 diabetes (T2D). METHODS:In this cross-sectional study of 342 people with T2D, the Japan National Health and Wellness Survey (NHWS) database 2016 were used. We treated the re...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00579-4
更新日期:2020-06-30 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-9-5
更新日期:2009-02-19 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-018-0272-0
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS. METHODS:We conducted...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-015-0061-y
更新日期:2015-11-04 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-9
更新日期:2013-03-01 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12902-019-0347-6
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Thyrotoxicosis is often caused by destructive thyroiditis (DT) or Graves' disease (GD), and a prompt and accurate differential diagnosis for thyrotoxicosis is needed as management strategy differs. A meta-analysis of published literature was performed to evaluate the diagnostic accuracy for differentiating G...
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pub_type: 杂志文章,meta分析
doi:10.1186/s12902-019-0388-x
更新日期:2019-06-06 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amo...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
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更新日期:2020-04-15 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12902-020-0532-7
更新日期:2020-04-20 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-22
更新日期:2013-07-04 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-5
更新日期:2012-05-30 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1472-6823-14-95
更新日期:2014-12-12 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 临床试验,杂志文章
doi:10.1186/s12902-019-0368-1
更新日期:2019-05-29 00:00:00
abstract:BACKGROUND:Whether lower dose cabergoline therapy for hyperprolactinemia increases risk of valvular dysfunction remains controversial. We examined valvular abnormalities among asymptomatic adults with hyperprolactinemia treated with dopamine agonists. METHODS:This cross-sectional study was conducted among adults recei...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-0507-8
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS:Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n =...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0424-x
更新日期:2019-09-02 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-14-32
更新日期:2014-04-10 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-019-0481-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian r...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00569-6
更新日期:2020-07-08 00:00:00
abstract:BACKGROUND:Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals. METHODS:We conducted a cross-se...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-36
更新日期:2013-09-29 00:00:00