Abstract:
BACKGROUND:Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (SAF) as a potential surrogate risk marker. METHODS:This study included a cross-sectional analysis of SAF in 77 patients with type 1 diabetes mellitus and 118 healthy controls across age categories (11-12, 13-14, 15-16, and 17-19 years old). In patients, the impact of current and historical glycated hemoglobin (HbA1c) values, age, and duration of diabetes on SAF was studied in a retrospective cohort study and analyzed with multivariable analyses. RESULTS:SAF was significantly and similarly higher in patients when compared with controls across all age categories (P ≤0.009). For patients, age, duration of diabetes, and current and historical HbA1c were associated with SAF in univariate analysis. Multivariate analysis showed no association between HbA1c and SAF. A subgroup of patients with a HbA1c-within-target (≤7.5 %/59 mmol/mol) were observed to have high SAF. CONCLUSION:Children and adolescents with type 1 diabetes show higher SAF than controls. The presumed correlation of high HbA1c with high SAF does not exist in all patients. Thus, use of this non-invasive measure may provide a surrogate marker for diabetic complications, additional to HbA1c.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
van der Heyden JC,Birnie E,Mul D,Bovenberg S,Veeze HJ,Aanstoot HJdoi
10.1186/s12902-016-0129-3subject
Has Abstractpub_date
2016-09-09 00:00:00pages
49issue
1issn
1472-6823pii
10.1186/s12902-016-0129-3journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). METHODS:We assessed single nucleotide polymorphisms (SNPs) in th...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-018-0271-1
更新日期:2018-09-19 00:00:00
abstract:BACKGROUND:The burden of non-communicable diseases is growing rapidly in low- and middle-income countries. Research suggests that health interventions that aim to improve patient self-management and empower patients to care actively for their disease will improve health outcomes over the long-term. There is, however, a...
journal_title:BMC endocrine disorders
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更新日期:2019-12-05 00:00:00
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pub_type: 杂志文章
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-5
更新日期:2012-05-30 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章,评审
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更新日期:2020-03-12 00:00:00
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更新日期:2015-12-08 00:00:00
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更新日期:2008-10-13 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1186/s12902-015-0044-z
更新日期:2015-09-09 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-9-13
更新日期:2009-05-09 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-15
更新日期:2012-08-16 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/s12902-016-0117-7
更新日期:2016-06-17 00:00:00
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doi:10.1186/1472-6823-14-1
更新日期:2014-01-02 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12902-015-0016-3
更新日期:2015-04-04 00:00:00
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pub_type: 杂志文章
doi:10.1186/1472-6823-10-4
更新日期:2010-03-19 00:00:00
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doi:10.1186/s12902-020-00628-y
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doi:10.1186/1472-6823-9-5
更新日期:2009-02-19 00:00:00
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更新日期:2020-04-20 00:00:00
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更新日期:2014-08-24 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-1
更新日期:2012-03-07 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-05-29 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-13-21
更新日期:2013-07-02 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-017-0162-x
更新日期:2017-02-17 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-0546-1
更新日期:2020-05-19 00:00:00
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journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/1472-6823-12-23
更新日期:2012-10-17 00:00:00
abstract:BACKGROUND:This study aimed to measure the effect of diabetes education using the novel method of "diabetes conversation map (DCM)" as compared to routine counselling (RC) on diabetes management self-efficacy (DMSE) among patients living with type 2 diabetes in Karachi, Pakistan. METHODS:A parallel arm randomized cont...
journal_title:BMC endocrine disorders
pub_type: 杂志文章
doi:10.1186/s12902-020-00572-x
更新日期:2020-06-16 00:00:00