Abstract：
BACKGROUND:Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). METHODS:We assessed single nucleotide polymorphisms (SNPs) in the IGF-1, IGF-2, IGF-3, IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and IGF -binding protein 3 (IGFBP-3) genes, and their association with demographics and metabolic proteins in girls with CPP. Z-scores of height, weight, and body mass index (BMI) were calculated with the WHO reference growth standards for children. RESULTS:IGF-1 serum levels of CPP group exhibited a higher correlation with bone age, z-scores of height and weight, and luteinizing hormone (LH) than those of control group, regardless of BMI adjustment. In the CPP group, height was associated with IGF-2(3580), an adenine to guanine (A/G) SNP at position + 3580. BMI in the CPP group was associated with IGF-2(3580), IGF1R, and the combinations of [IGF-2(3580) + IGF2R], and [IGF-2(3580) + IGFBP-3]. Body weight in the CPP group was associated with the combination of [IGF-2(3580) + IGFBP-3] (p = 0.024). Weight and BMI were significantly associated with the combination of [IGF-2(3580) + IGF2R + IGFBP-3] in the CPP group. These associations were not significantly associated with z-scores of weight, height, or BMI. The distribution of these genotypes, haplotypes, and allele frequencies were similar between control and CPP groups. CONCLUSIONS:These known SNPs of these IGF-1 axis genes appear to play minor roles in the risk for development of CPP.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Chang HP,Yang SF,Wang SL,Su PHdoi
10.1186/s12902-018-0271-1subject
Has Abstractpub_date
2018-09-19 00:00:00pages
66issue
1issn
1472-6823pii
10.1186/s12902-018-0271-1journal_volume
18pub_type
杂志文章abstract：UNLABELLED: BACKGROUND:Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatment is intensified. METHODS:DiaRegis is a prospective German registry that follows 3810 ...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-23
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abstract：BACKGROUND:Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation. CASE PRESENTATION:We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extr...
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abstract：BACKGROUND:Hypoglycemia is a common complication of diabetes treatment. This paper describes symptoms, predecessors, consequences and medications associated with the first episode of severe hypoglycemia among ACCORD participants with type 2 diabetes, and compares these between intensive (Int: goal A1C <6.0%) and standa...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-5
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journal_title：BMC endocrine disorders
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doi：10.1186/1472-6823-14-24
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00608-2
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-14-2
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
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doi：10.1186/1472-6823-8-13
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-018-0272-0
更新日期：2018-07-03 00:00:00
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pub_type： 杂志文章
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journal_title：BMC endocrine disorders
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
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更新日期：2012-03-07 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
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更新日期：2016-09-09 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-8-3
更新日期：2008-03-27 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
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更新日期：2020-01-06 00:00:00
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pub_type： 杂志文章
doi：10.1186/1472-6823-14-52
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doi：10.1186/s12902-018-0290-y
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