Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus.

Abstract:

BACKGROUND:While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. METHODS:The study participants comprised 724 Japanese T2DM outpatients free of history of cardiovascular diseases. The relationships between sleep quality (assessed by the Pittsburgh Sleep Quality Index (PSQI)) and various clinical and laboratory parameters were investigated. RESULTS:The mean PSQI was 5.1 ± 3.0 (±SD). Patients were divided into three groups based on the total PSQI score; subjects with good sleep quality (n = 462), average sleep quality (n = 185), and poor sleep quality (n = 77). In the age/gender-adjusted model, patients with poor sleep quality tended to be obese, evening type and depressed. However, other lifestyles showed no significant trends. Alanine aminotransferase, fasting blood glucose, HbA1c, systolic blood pressure, urinary albumin excretion, and brachial-ankle pulse wave velocity (baPWV) tended to be higher in patients with poor sleep quality. High baPWV was the only parameter that correlated with poor sleep in a model adjusted for several other lifestyle factors. CONCLUSIONS:Our study indicates that poor sleep quality in T2DM patients correlates with increased arterial wall stiffness, a marker of atherosclerosis and a risk factor for cardiovascular diseases.

journal_name

BMC Endocr Disord

journal_title

BMC endocrine disorders

authors

Osonoi Y,Mita T,Osonoi T,Saito M,Tamasawa A,Nakayama S,Someya Y,Ishida H,Kanazawa A,Gosho M,Fujitani Y,Watada H

doi

10.1186/s12902-015-0026-1

subject

Has Abstract

pub_date

2015-06-18 00:00:00

pages

29

issn

1472-6823

pii

10.1186/s12902-015-0026-1

journal_volume

15

pub_type

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