Abstract：
BACKGROUND:The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS:This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. RESULTS:Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46-0.92) for diabetes and 0.589 (95% CI: 0.39-0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). CONCLUSION:The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Koh ES,Kim SJ,Yoon HE,Chung JH,Chung S,Park CW,Chang YS,Shin SJdoi
10.1186/1472-6823-14-24subject
Has Abstractpub_date
2014-03-08 00:00:00pages
24issn
1472-6823pii
1472-6823-14-24journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Insulin resistance and diabetes are associated with increased oxidative stress and impairment of cellular defence systems. Our purpose was to investigate the interaction between glucose metabolism, antioxidative capacity and heat shock protein (HSP) defence in different skeletal muscle phenotypes among middl...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-8-3
更新日期：2008-03-27 00:00:00
abstract：BACKGROUND:This study tested the association between serum levels of microRNA-486, -146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM). METHODS:the study included 120 children; divided into three groups: G1 (50 healthy), G2 (35 obese) and G3 (35 obese with T2DM). Th...
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abstract：BACKGROUND:The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS. METHODS:We conducted...
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doi：10.1186/s12902-015-0061-y
更新日期：2015-11-04 00:00:00
abstract：BACKGROUND:Caloric restriction is an effective way to treat Type 2 diabetes (T2D). However, chronic and severe restriction of food intake is difficult to sustain and is known to promote slower metabolism. Intermittent and frequent fasting can exert similar metabolic effects, but may be even more challenging for most pa...
journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-020-00576-7
更新日期：2020-06-24 00:00:00
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更新日期：2019-09-02 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章,随机对照试验
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更新日期：2019-12-11 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章,meta分析,评审
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更新日期：2015-10-12 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-9-16
更新日期：2009-06-21 00:00:00
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journal_title：BMC endocrine disorders
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更新日期：2012-08-16 00:00:00
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doi：10.1186/s12902-019-0370-7
更新日期：2019-05-07 00:00:00
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journal_title：BMC endocrine disorders
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更新日期：2011-03-22 00:00:00
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journal_title：BMC endocrine disorders
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更新日期：2018-07-03 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-8-9
更新日期：2008-07-31 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0063-9
更新日期：2015-10-29 00:00:00
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journal_title：BMC endocrine disorders
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更新日期：2014-12-01 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
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更新日期：2010-05-17 00:00:00
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pub_type： 杂志文章
doi：10.1186/1472-6823-6-3
更新日期：2006-05-10 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-4-2
更新日期：2004-06-29 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/1472-6823-12-1
更新日期：2012-03-07 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2019-05-29 00:00:00
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journal_title：BMC endocrine disorders
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更新日期：2014-01-06 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
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更新日期：2018-02-13 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-10-29 00:00:00
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journal_title：BMC endocrine disorders
pub_type： 杂志文章
doi：10.1186/s12902-015-0026-1
更新日期：2015-06-18 00:00:00
abstract：BACKGROUND:Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. METHODS:We investigated the association b...
journal_title：BMC endocrine disorders
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更新日期：2020-01-06 00:00:00
