Abstract:
BACKGROUND:Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the association with vascular target organ damage at this early time point of the diabetes disease. METHODS:Ambulatory blood pressure monitoring was performed in 100 patients with newly diagnosed type 2 diabetes and 100 age and sex matched controls. MBPS and SND-ratio were calculated. Markers of early vascular target organ damage included pulse wave velocity (PWV), white matter lesions (WML) on brain MRI, and urine albumin/creatinine ratio (UAE). RESULTS:No significant differences in MBPS were found between diabetic patients and controls. Neither MBPS or SND-ratio were associated with PWV, UAE or WML in the diabetic group independently of age, gender and 24-h systolic blood pressure. 40.2 % of diabetic patients and 25.8 % of controls were classified as non-dippers (p = 0.03). CONCLUSION:MBPS and SND-ratio are not associated with subclinical markers of vascular target organ damage in our study sample of newly diagnosed type 2 diabetic patients.
journal_name
BMC Endocr Disordjournal_title
BMC endocrine disordersauthors
Lyhne JM,Laugesen E,Høyem P,Cichosz S,Christiansen JS,Knudsen ST,Hansen KW,Hansen TK,Poulsen PLdoi
10.1186/s12902-015-0068-4subject
Has Abstractpub_date
2015-12-03 00:00:00pages
77issn
1472-6823pii
10.1186/s12902-015-0068-4journal_volume
15pub_type
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pub_type: 杂志文章,评审
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