How should we interrogate the hypothalamic-pituitary-adrenal axis in patients with suspected hypopituitarism?

abstract：BACKGROUND:Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). METHODS:We assessed single nucleotide polymorphisms (SNPs) in th...

journal_title：BMC endocrine disorders

authors： Chang HP,Yang SF,Wang SL,Su PH

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the 'real-world' medication utilization patterns for patients with type 2 diabetes initiating exenatide BID or glargine. The objective of this study was...

journal_title：BMC endocrine disorders

authors： Pawaskar M,Bonafede M,Johnson B,Fowler R,Lenhart G,Hoogwerf B

更新日期：2013-06-22 00:00:00

abstract：BACKGROUND:Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian r...

journal_title：BMC endocrine disorders

authors： Lv PP,Jin M,Rao JP,Chen J,Wang LQ,Huang CC,Yang SQ,Yao QP,Feng L,Shen JM,Feng C

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Insulin resistance and diabetes are associated with increased oxidative stress and impairment of cellular defence systems. Our purpose was to investigate the interaction between glucose metabolism, antioxidative capacity and heat shock protein (HSP) defence in different skeletal muscle phenotypes among middl...

journal_title：BMC endocrine disorders

authors： Venojärvi M,Aunola S,Puhke R,Marniemi J,Hämäläinen H,Halonen JP,Lindström J,Rastas M,Hällsten K,Nuutila P,Hänninen O,Atalay M

更新日期：2008-03-27 00:00:00

abstract：BACKGROUND:Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and is characterized by the presence of insulin autoantibodies. Patients with IAS usually complain of hypoglycemia without any previous insulin received. Glucocorticoids and immunosuppressants are used to treat IAS. CASE PRESENTATION:We repor...

journal_title：BMC endocrine disorders

authors： Shen Y,Song X,Ren Y

更新日期：2019-12-28 00:00:00

abstract：BACKGROUND:Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from T...

journal_title：BMC endocrine disorders

authors： Emral R,Tetiker T,Sahin I,Sari R,Kaya A,Yetkin İ,Cil SU,Tütüncü NB,IO HAT investigator group.

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Chronic insulin resistance, exacerbated in the course of pregnancy, is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). We hypothesise that the degree of insulin resistance, assessed at diagnosis of GDM, is a parameter of its pathophysiologic heterogeneity and/or severity. Thus...

journal_title：BMC endocrine disorders

authors： Sokup A,Ruszkowska-Ciastek B,Góralczyk K,Walentowicz M,Szymański M,Rość D

更新日期：2013-07-02 00:00:00

abstract：BACKGROUND:Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by mutations in the zinc finger transcription factor gene, GATA3. GATA3 has 2 zinc finger domains, which play an important role in the increase in target gene transcription activity. CASE PRESENTATI...

journal_title：BMC endocrine disorders

authors： Okawa T,Yoshida M,Usui T,Kudou T,Iwasaki Y,Fukuoka K,Takahashi N,Uehara Y,Oiso Y

更新日期：2015-10-30 00:00:00

abstract：BACKGROUND:Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population. METHODS:In 2001-2004, 1811 men and women (30-75 years) were randomly selected fro...

journal_title：BMC endocrine disorders

authors： Larsson CA,Gullberg B,Råstam L,Lindblad U

更新日期：2009-06-21 00:00:00

abstract：BACKGROUND:Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (...

journal_title：BMC endocrine disorders

authors： van der Heyden JC,Birnie E,Mul D,Bovenberg S,Veeze HJ,Aanstoot HJ

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective ...

journal_title：BMC endocrine disorders

authors： Wang X,Shu W,Du J,Du M,Wang P,Xue M,Zheng H,Jiang Y,Yin S,Liang D,Wang R,Hou L

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Addison's disease, or primary adrenal insufficiency, is often associated with reduced well-being and fatigue despite use of currently recommended adrenal hormone replacement. Hypoglycaemia is a known manifestation of glucocorticoid deficiency, but is generally considered rare in adults and not relevant to tr...

journal_title：BMC endocrine disorders

authors： Petersen KS,Rushworth RL,Clifton PM,Torpy DJ

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in insulin secretion, insulin sensitivity, and glucose metabolism, the present study was conducted to ...

journal_title：BMC endocrine disorders

authors： Liu HL,Li TT,Yu AQ,Li J,Li X,Li L,Kaifu T

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:To estimate the proportion of diabetic patients (DPts) with peripheral vascular disease treated at a primary health care site after an endocrinologist-based intervention, who meet ATP III and Steno targets of metabolic control, as well as to compare the outcome with the results of the patients treated by end...

journal_title：BMC endocrine disorders

authors： Duran A,Runkle I,Matía P,de Miguel MP,Garrido S,Cervera E,Fernandez MD,Torres P,Lillo T,Martin P,Cabrerizo L,de la Torre NG,Calle JR,Ibarra J,Charro AL,Calle-Pascual AL

更新日期：2008-07-31 00:00:00

abstract：BACKGROUND:There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and fr...

journal_title：BMC endocrine disorders

authors： Alhambra-Expósito MR,Molina-Puerta MJ,Prior-Sánchez MI,Manzano-García G,Calañas-Continente A,Gálvez-Moreno MA

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. METHODS:In this study DLG1-AS1 and miR-199a-3p in plasma of both PT...

journal_title：BMC endocrine disorders

authors： He T,Wang H,Sun J,Wu J,Gong F,Li S,Wang H,Li Y

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for goitre among schoolchildren in South Tajikistan. METHODS:Ten primary schools in four districts in ...

journal_title：BMC endocrine disorders

authors： Matthys B,Davlatmamadova M,Karimova G,Jean-Richard V,Zimmermann MB,Wyss K

更新日期：2013-11-02 00:00:00

abstract：BACKGROUND:We report a novel mutation within the StAR gene, causing congenital adrenal hyperplasia, with the so far unreported association with heterochromia iridis. CASE PRESENTATION:In a now 15-year-old girl (born at 41 + 6 weeks of gestation) adrenal failure was diagnosed in the neonatal period based on the clinica...

journal_title：BMC endocrine disorders

authors： Splittstösser V,Schreiner F,Gohlke B,Welzel M,Holterhus PM,Woelfle J

更新日期：2019-10-30 00:00:00

abstract：BACKGROUND:Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is cause...

journal_title：BMC endocrine disorders

authors： Dietrich JW,Stachon A,Antic B,Klein HH,Hering S

更新日期：2008-10-13 00:00:00

abstract：BACKGROUND:11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician's diagnosis of remitting diabetes. Our aim was to identify patients with remitting diabetes whose clinical presentation is not explained by any known aetiology of diabetes....

journal_title：BMC endocrine disorders

authors： Babiker T,Chakera AJ,Shepherd M,Hattersley AT

更新日期：2014-06-09 00:00:00

abstract：BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...

journal_title：BMC endocrine disorders

authors： Cho EA,Yoon JH,Kim HK,Kang HC

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed pr...

journal_title：BMC endocrine disorders

authors： Iwayama H,Hirase S,Nomura Y,Ito T,Morita H,Otake K,Okumura A,Takagi J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:The hormone somatostatin inhibits growth hormone release from the pituitary gland and is theoretically linked to diabetes and diabetes related complications. This study aimed to investigate the relationship between levels of the stable somatostatin precursor, N-terminal prosomatostatin (NT-proSST), with mort...

journal_title：BMC endocrine disorders

authors： van Dijk PR,Landman GW,van Essen L,Struck J,Groenier KH,Bilo HJ,Bakker SJ,Kleefstra N

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amo...

journal_title：BMC endocrine disorders

authors： Shiferaw WS,Akalu TY,Work Y,Aynalem YA

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out ...

journal_title：BMC endocrine disorders

authors： Keller P,Gburcik V,Petrovic N,Gallagher IJ,Nedergaard J,Cannon B,Timmons JA

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND:Ovarian reserve, vital for reproductive function, can be adversely affected by thyroid diseases. Despite alternations of thyroid hormones with ageing, data on interactions between the overtime trend of thyroid functions and ovarian reserve status has rarely been reported. We aimed to examine the overtime tre...

journal_title：BMC endocrine disorders

authors： Bahri S,Tehrani FR,Amouzgar A,Rahmati M,Tohidi M,Vasheghani M,Azizi F

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Several studies have shown the association of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 with type 2 diabetes (T2D). However, the association of alternative variants and haplotypes of SLC30A8 with T2D have not been studied in different populations. The aim of this study is to a...

journal_title：BMC endocrine disorders

authors： Salem SD,Saif-Ali R,Ismail IS,Al-Hamodi Z,Muniandy S

更新日期：2014-01-06 00:00:00

abstract：BACKGROUND:The burden of non-communicable diseases is growing rapidly in low- and middle-income countries. Research suggests that health interventions that aim to improve patient self-management and empower patients to care actively for their disease will improve health outcomes over the long-term. There is, however, a...

journal_title：BMC endocrine disorders

authors： Abrahams N,Gilson L,Levitt NS,Dave JA

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Most of the patients with type 1 and V hyperlipoproteinemia (HLP) present with symptoms and signs of acute pancreatitis due to marked elevation of triglycerides, but this baby presented with a chest infection, which was later diagnosed as type V HLP on laboratory workup. CASE PRESENTATION:We report a case o...

journal_title：BMC endocrine disorders

authors： Dildar S,Shamsi TS

更新日期：2020-02-11 00:00:00

abstract：:Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT system is synthesized in the rat and human heart. The direct myocardial infusion with OT into an ischemic or failing heart has the potential to elicit a variety of cardioprotective effects. OT treatment attenuates cardiomyocyte (C...

journal_title：BMC endocrine disorders

authors： Jankowski M,Broderick TL,Gutkowska J

更新日期：2016-06-07 00:00:00