Risk assessment for foot ulcers among Tunisian subjects with diabetes: a cross sectional outpatient study.

Abstract:

BACKGROUND:Diabetic foot is an underestimated and redoubtable diabetes complication. The aims of our study were to assess diabetic foot ulcer risk factors according to International Working Group on the Diabetic Foot (IWGDF) classification, stratify patients into risk categories and identify factors associated with higher-risk grade. METHODS:Cross-sectional setting over a period of 07 months, patients were randomly selected from the diabetic outpatients attending our unit of diabetology. Questionnaire and clinical examination were made by the same physician. Patients free of active foot ulcer were included. RESULTS:Among 230 patients evaluated, 10 had an active foot ulcer and were excluded. Five patients (2.27%) had a history of foot ulcer and 3(1.36%) had a lower-limb amputation. Sensory neuropathy, as measured by the 5.07(10 g) Semmes-Weinstein monofilament testing, was present in 23.63% of patients, whereas 36.82% had a peripheral arterial disease based on clinical findings, and 43.63% had foot deformities. According to the IWGDF classification, Group 0: 72.72%, Group 1: 5.9%, Group 2: 17.73% and Group 3: 3.63%. After univariate analysis, patients in higher-risk groups were significantly more often female, had higher age and BMI, longer diabetes duration, elevated waist circumference, low school level, retinopathy and hyperkeratosis. Multivariate logistic regression analysis identified 3 significant independent factors associated with high-risk groups: retinopathy (OR = 2.529, CI95 [1.131-5.655], p = 0.024), hyperkeratosis (OR = 2.658, CI95 [1.222-5.783], p = 0.014) and school level (OR = 0.489, CI95 [0.253-9.44], p = 0.033). CONCLUSIONS:Risk factors for foot ulceration were rather common in outpatients with diabetes. The screening of patients at risk for foot ulceration should start early, integrated with sustainable patient education.

journal_name

BMC Endocr Disord

journal_title

BMC endocrine disorders

authors

Zantour B,Bouchareb S,El Ati Z,Boubaker F,Alaya W,Kossomtini W,Sfar MH

doi

10.1186/s12902-020-00608-2

subject

Has Abstract

pub_date

2020-08-24 00:00:00

pages

128

issue

1

issn

1472-6823

pii

10.1186/s12902-020-00608-2

journal_volume

20

pub_type

杂志文章
  • Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis.

    abstract:BACKGROUND:We aimed to explore metabolite biomarkers that could be used to identify pre-diabetes and type 2 diabetes mellitus (T2DM) using systematic review and meta-analysis. METHODS:Four databases, the Cochrane Library, EMBASE, PubMed and Scopus were selected. A random effect model and a fixed effect model were appl...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00653-x

    authors: Long J,Yang Z,Wang L,Han Y,Peng C,Yan C,Yan D

    更新日期:2020-11-23 00:00:00

  • Two-year assessment of the efficacy and safety of sitagliptin in elderly patients with type 2 diabetes: Post hoc analysis of the ASSET-K study.

    abstract:BACKGROUND:There have only been a few reports about use of dipeptidyl peptidase 4 (DPP-4) inhibitors in elderly patients with type 2 diabetes mellitus (T2DM), suggesting that the safety of these agents has not been sufficiently demonstrated. We performed a comparative review of the efficacy and safety of sitagliptin fo...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0033-2

    authors: Umezawa S,Kubota A,Maeda H,Kanamori A,Matoba K,Jin Y,Minagawa F,Obana M,Iemitsu K,Ito S,Amamiya H,Kaneshiro M,Takai M,Kaneshige H,Hoshino K,Ishikawa M,Minami N,Takuma T,Sasai N,Aoyagi S,Kawata T,Mokubo A,Miyai

    更新日期:2015-07-03 00:00:00

  • Beta cell response to a mixed meal in nigerian patients with type 2 diabetes.

    abstract:BACKGROUND:The pathophysiology of type2 diabetes involves both insulin resistance and poor beta cell function. Studies have been done in several populations to assess the relative importance of these mechanisms in individual patients. In our environment studies to assess beta cell function have been done with glucagon ...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-11

    authors: Young EE,Chinenye S,Unachukwu CN

    更新日期:2012-06-27 00:00:00

  • Role of enteral nutrition in nonthyroidal illness syndrome: a retrospective observational study.

    abstract:BACKGROUND:The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS. METHODS:We conducted...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0061-y

    authors: Li R,Ren J,Wu Q,Wang G,Wu X,Chen J,Li G,Hong Z,Ren H,Zhao Y,Li J

    更新日期:2015-11-04 00:00:00

  • Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.

    abstract:BACKGROUND:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed pr...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0246-2

    authors: Iwayama H,Hirase S,Nomura Y,Ito T,Morita H,Otake K,Okumura A,Takagi J

    更新日期:2018-03-27 00:00:00

  • An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study.

    abstract:BACKGROUND:Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from T...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0238-2

    authors: Emral R,Tetiker T,Sahin I,Sari R,Kaya A,Yetkin İ,Cil SU,Tütüncü NB,IO HAT investigator group.

    更新日期:2018-02-13 00:00:00

  • Mobile health in the management of type 1 diabetes: a systematic review and meta-analysis.

    abstract:BACKGROUND:As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective ...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12902-019-0347-6

    authors: Wang X,Shu W,Du J,Du M,Wang P,Xue M,Zheng H,Jiang Y,Yin S,Liang D,Wang R,Hou L

    更新日期:2019-02-13 00:00:00

  • Obtaining evidence base for the development of Feel4Diabetes intervention to prevent type 2 diabetes - a narrative literature review.

    abstract:BACKGROUND:Feel4Diabetes was a school and community based intervention aiming to promote healthy lifestyle and tackle obesity for the prevention of type 2 diabetes among families in 6 European countries. We conducted this literature review in order to guide the development of evidence-based implementation of the Feel4D...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,评审

    doi:10.1186/s12902-019-0468-y

    authors: Kivelä J,Wikström K,Virtanen E,Georgoulis M,Cardon G,Civeira F,Iotova V,Karuranga E,Ko W,Liatis S,Makrilakis K,Manios Y,Mateo-Gallego R,Nanasi A,Rurik I,Tankova T,Tsochev K,Van Stappen V,Lindström J,Feel4Diabetes re

    更新日期:2020-03-12 00:00:00

  • Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

    abstract:BACKGROUND:The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS:The study included 1482 sub...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0232-8

    authors: Song B,Zuo Z,Tan J,Guo J,Teng W,Lu Y,Liu C

    更新日期:2018-01-27 00:00:00

  • Comparison of health-related quality of Life (HRQOL) among patients with pre-diabetes, diabetes and normal glucose tolerance, using the 15D-HRQOL questionnaire in Greece: the DEPLAN study.

    abstract:BACKGROUND:Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons' quality of life is not adequately elucidated. The purpose of this study was to compare the Health-Related Quality of Life (HRQOL) of persons with pre-diabetes with...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0261-3

    authors: Makrilakis K,Liatis S,Tsiakou A,Stathi C,Papachristoforou E,Perrea D,Katsilambros N,Kontodimopoulos N,Niakas D

    更新日期:2018-05-29 00:00:00

  • Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.

    abstract:BACKGROUND:The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS:We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12902-017-0209-z

    authors: Zhou Y,Zhang M,Ke S,Liu L

    更新日期:2017-10-03 00:00:00

  • Gender-modulated risk of coronary heart disease, diabetes and coronary mortality among Turks for three major risk factors, and residual adiposity risk.

    abstract:BACKGROUND:We determined the proportion of the effects of body mass index (BMI) or its categories on cardiometabolic outcomes mediated through systolic blood pressure (SBP), total cholesterol and fasting glucose. METHODS:Cox regression analyses were performed for incident outcomes among Turkish Adult Risk Factor study...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-016-0134-6

    authors: Can G,Onat A,Yurtseven E,Karadeniz Y,Akbaş-Şimşek T,Kaya A,Yüksel H

    更新日期:2016-09-29 00:00:00

  • Geographic patterns in patient demographics and insulin use in 18 countries, a global perspective from the multinational observational study assessing insulin use: understanding the challenges associated with progression of therapy (MOSAIc).

    abstract:BACKGROUND:Among patients with type 2 diabetes, insulin intensification to achieve glycemic targets occurs less often than clinically indicated. Barriers to intensification are not well understood. We present patients' baseline characteristics from MOSAIc, a study investigating patient-, physician-, and healthcare envi...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12902-015-0044-z

    authors: Polinski JM,Kim SC,Jiang D,Hassoun A,Shrank WH,Cos X,Rodríguez-Vigil E,Suzuki S,Matsuba I,Seeger JD,Eddings W,Brill G,Curtis BH

    更新日期:2015-09-09 00:00:00

  • Possible modulatory effect of endogenous islet catecholamines on insulin secretion.

    abstract::BACKGROUND: The possible participation of endogenous islet catecholamines (CAs) in the control of insulin secretion was tested. METHODS: Glucose-induced insulin secretion was measured in the presence of 3-Iodo-L-Tyrosine (MIT), a specific inhibitor of tyrosine-hydroxylase activity, in fresh and precultured islets isol...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-1-1

    authors: Borelli MI,Gagliardino JJ

    更新日期:2001-01-01 00:00:00

  • A case of masked toxic adenoma in a patient with non-thyroidal illness.

    abstract:BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-1

    authors: Cho EA,Yoon JH,Kim HK,Kang HC

    更新日期:2014-01-02 00:00:00

  • Effects of the Proactive interdisciplinary self-management (PRISMA) program on self-reported and clinical outcomes in type 2 diabetes: a pragmatic randomized controlled trial.

    abstract:BACKGROUND:Diabetes self-management education can be helpful for patients with type 2 diabetes in managing their condition. We aimed to study the effects of the group-based PRoactive Interdisciplinary Self-MAnagement (PRISMA) training program on self-reported and clinical outcomes in patients with type 2 diabetes treat...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12902-019-0466-0

    authors: du Pon E,Kleefstra N,Cleveringa F,van Dooren A,Heerdink ER,van Dulmen S

    更新日期:2019-12-11 00:00:00

  • Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis.

    abstract:BACKGROUND:Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amo...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-0534-5

    authors: Shiferaw WS,Akalu TY,Work Y,Aynalem YA

    更新日期:2020-04-15 00:00:00

  • Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in peripheral blood mononuclear cells (PBMCs) to see if these cells can be used to study these anti-inf...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-9-8

    authors: Bragt MC,Plat J,Mensink M,Schrauwen P,Mensink RP

    更新日期:2009-02-25 00:00:00

  • The effects of cognitive behavioral therapy for insomnia in people with type 2 diabetes mellitus, pilot RCT part II: diabetes health outcomes.

    abstract:BACKGROUND:Previous studies have shown the negative impact of sleep disturbances, specifically insomnia symptoms, on glucose metabolism for people with type 2 diabetes (T2D). People with insomnia symptoms are at risk of poor glycemic control and suboptimal diabetes self-care behavior (DSCB). Investigating the impact of...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00612-6

    authors: Alshehri MM,Alothman SA,Alenazi AM,Rucker JL,Phadnis MA,Miles JM,Siengsukon CF,Kluding PM

    更新日期:2020-09-05 00:00:00

  • A novel mutation of the StAR gene with congenital adrenal hyperplasia and its association with heterochromia iridis: a case report.

    abstract:BACKGROUND:We report a novel mutation within the StAR gene, causing congenital adrenal hyperplasia, with the so far unreported association with heterochromia iridis. CASE PRESENTATION:In a now 15-year-old girl (born at 41 + 6 weeks of gestation) adrenal failure was diagnosed in the neonatal period based on the clinica...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-019-0448-2

    authors: Splittstösser V,Schreiner F,Gohlke B,Welzel M,Holterhus PM,Woelfle J

    更新日期:2019-10-30 00:00:00

  • Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes.

    abstract:BACKGROUND:A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown. This study aimed to investigate the relationship between circulating neutrophils and DKD...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00597-2

    authors: Yu Y,Lin Q,Ye D,Wang Y,He B,Li Y,Huang G,Zhou Z,Xiao Y

    更新日期:2020-10-22 00:00:00

  • Cost-effectiveness comparison between palpation- and ultrasound-guided thyroid fine-needle aspiration biopsies.

    abstract:BACKGROUND:The aim of this study is to perform a cost-effectiveness comparison between palpation-guided thyroid fine-needle aspiration biopsies (P-FNA) and ultrasound-guided thyroid FNA biopsies (USG-FNA). METHODS:Each nodule was considered as a case. Diagnostic steps were history and physical examination, TSH measure...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-9-14

    authors: Can AS

    更新日期:2009-05-16 00:00:00

  • The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome.

    abstract:BACKGROUND:Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is cause...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-8-13

    authors: Dietrich JW,Stachon A,Antic B,Klein HH,Hering S

    更新日期:2008-10-13 00:00:00

  • Recurrent nocturnal hypoglycaemia as a cause of morning fatigue in treated Addison's disease--favourable response to dietary management: a case report.

    abstract:BACKGROUND:Addison's disease, or primary adrenal insufficiency, is often associated with reduced well-being and fatigue despite use of currently recommended adrenal hormone replacement. Hypoglycaemia is a known manifestation of glucocorticoid deficiency, but is generally considered rare in adults and not relevant to tr...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0058-6

    authors: Petersen KS,Rushworth RL,Clifton PM,Torpy DJ

    更新日期:2015-10-24 00:00:00

  • Implication of intracellular localization of transcriptional repressor PLZF in thyroid neoplasms.

    abstract:BACKGROUND:Promyelocytic leukaemia zinc finger (PLZF) is a transcriptional repressor that was originally isolated from a patient with promyelocytic leukaemia. PLZF also affects key elements for cell cycle progression, such as cyclin A, and can affect the tumourigenicity of various cancers. Thus far, the behaviour of PL...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-52

    authors: Matsuzawa K,Izawa S,Ohkura T,Ohkura H,Ishiguro K,Yoshida A,Takiyama Y,Haneda M,Shigemasa C,Yamamoto K,Taniguchi S

    更新日期:2014-07-03 00:00:00

  • Severe hypoglycemia symptoms, antecedent behaviors, immediate consequences and association with glycemia medication usage: Secondary analysis of the ACCORD clinical trial data.

    abstract:BACKGROUND:Hypoglycemia is a common complication of diabetes treatment. This paper describes symptoms, predecessors, consequences and medications associated with the first episode of severe hypoglycemia among ACCORD participants with type 2 diabetes, and compares these between intensive (Int: goal A1C <6.0%) and standa...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-5

    authors: Bonds DE,Miller ME,Dudl J,Feinglos M,Ismail-Beigi F,Malozowski S,Seaquist E,Simmons DL,Sood A

    更新日期:2012-05-30 00:00:00

  • Role of anti-Müllerian hormone and testosterone in follicular growth: a cross-sectional study.

    abstract:BACKGROUND:Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian r...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00569-6

    authors: Lv PP,Jin M,Rao JP,Chen J,Wang LQ,Huang CC,Yang SQ,Yao QP,Feng L,Shen JM,Feng C

    更新日期:2020-07-08 00:00:00

  • Iodine nutritional status and risk factors for goitre among schoolchildren in South Tajikistan.

    abstract:BACKGROUND:Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for goitre among schoolchildren in South Tajikistan. METHODS:Ten primary schools in four districts in ...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-13-50

    authors: Matthys B,Davlatmamadova M,Karimova G,Jean-Richard V,Zimmermann MB,Wyss K

    更新日期:2013-11-02 00:00:00

  • Factors associated with initiation of antihyperglycaemic medication in UK patients with newly diagnosed type 2 diabetes.

    abstract:AIM:To assess the factors associated with antihyperglycaemic medication initiation in UK patients with newly diagnosed type 2 diabetes. METHODS:In a retrospective cohort study, patients with newly diagnosed type 2 diabetes were identified during the index period of 2003-2005. Eligible patients were ≥ 30 years old at t...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-1

    authors: Sinclair AJ,Alexander CM,Davies MJ,Zhao C,Mavros P

    更新日期:2012-03-07 00:00:00

  • Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population.

    abstract:BACKGROUND:The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. METHODS:This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participa...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-24

    authors: Koh ES,Kim SJ,Yoon HE,Chung JH,Chung S,Park CW,Chang YS,Shin SJ

    更新日期:2014-03-08 00:00:00