Medullary thyroid carcinoma with double negative calcitonin and CEA: a case report and update of literature review.

Abstract:

BACKGROUND:Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET mutation, it is associated to multiple endocrine neoplasia type 2 (25% of cases). The biochemical features of medullary thyroid carcinoma include the production of calcitonin and carcinoembryogenic antigen. The above-mentioned features are useful in the diagnostic process as well as in the follow up and in the prognostication of the disease. Even if calcitonin elevation is strongly associated to MTC, it can also be found increased in many pathological different conditions as pregnancy, lactation, C-cells hyperplasia, autoimmune thyroiditis, end stage renal disease, lung and prostate cancer and several neuroendocrine tumours. Major medullary thyroid tumours are usually connected to high doses of circulating calcitonin, in fact non-secretory variants have hardly been described. CASE PRESENTATION:We herein report the case of a 59 years old male, who had undergone total thyroidectomy for multinodular goiter with negative preoperative calcitonin, showing medullary thyroid carcinoma at definitive pathology. To the best of our knowledge, this is the first case documenting a non-secretory medullary thyroid carcinoma, with double negative markers at the time of diagnosis and at the relapse. CONCLUSION:A Literature review underlining pathological hypothesis, differential diagnosis and alternative and innovative biomarkers to identify non-secretory medullary thyroid carcinoma was carried out.

journal_name

BMC Endocr Disord

journal_title

BMC endocrine disorders

authors

Gambardella C,Offi C,Clarizia G,Romano RM,Cozzolino I,Montella M,Di Crescenzo RM,Mascolo M,Cangiano A,Di Martino S,Candela G,Docimo G

doi

10.1186/s12902-019-0435-7

subject

Has Abstract

pub_date

2019-10-16 00:00:00

pages

103

issue

1

issn

1472-6823

pii

10.1186/s12902-019-0435-7

journal_volume

19

pub_type

杂志文章,评审
  • Obtaining evidence base for the development of Feel4Diabetes intervention to prevent type 2 diabetes - a narrative literature review.

    abstract:BACKGROUND:Feel4Diabetes was a school and community based intervention aiming to promote healthy lifestyle and tackle obesity for the prevention of type 2 diabetes among families in 6 European countries. We conducted this literature review in order to guide the development of evidence-based implementation of the Feel4D...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,评审

    doi:10.1186/s12902-019-0468-y

    authors: Kivelä J,Wikström K,Virtanen E,Georgoulis M,Cardon G,Civeira F,Iotova V,Karuranga E,Ko W,Liatis S,Makrilakis K,Manios Y,Mateo-Gallego R,Nanasi A,Rurik I,Tankova T,Tsochev K,Van Stappen V,Lindström J,Feel4Diabetes re

    更新日期:2020-03-12 00:00:00

  • Lipid accumulation product (LAP) was independently associatedwith obstructive sleep apnea in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mell...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00661-x

    authors: Dong L,Lin M,Wang W,Ma D,Chen Y,Su W,Chen Z,Wang S,Li X,Li Z,Liu C

    更新日期:2020-12-09 00:00:00

  • Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.

    abstract:BACKGROUND:The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS:We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12902-017-0209-z

    authors: Zhou Y,Zhang M,Ke S,Liu L

    更新日期:2017-10-03 00:00:00

  • Poor sleep quality is associated with increased arterial stiffness in Japanese patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. METHODS:The study p...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0026-1

    authors: Osonoi Y,Mita T,Osonoi T,Saito M,Tamasawa A,Nakayama S,Someya Y,Ishida H,Kanazawa A,Gosho M,Fujitani Y,Watada H

    更新日期:2015-06-18 00:00:00

  • Evaluation of the thyroid characteristics of patients with growth hormone-secreting adenomas.

    abstract:BACKGROUND:Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucidated. METHODS:Overall, 134 consecutive participants with growth hormone (GH)-secreting adenoma (n =...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-019-0424-x

    authors: Xu D,Wu B,Li X,Cheng Y,Chen D,Fang Y,Du Q,Chen Z,Wang X

    更新日期:2019-09-02 00:00:00

  • Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls.

    abstract:BACKGROUND:Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). METHODS:We assessed single nucleotide polymorphisms (SNPs) in th...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0271-1

    authors: Chang HP,Yang SF,Wang SL,Su PH

    更新日期:2018-09-19 00:00:00

  • A diagnostic approach for defining idiopathic remitting diabetes: a retrospective cohort study.

    abstract:BACKGROUND:11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician's diagnosis of remitting diabetes. Our aim was to identify patients with remitting diabetes whose clinical presentation is not explained by any known aetiology of diabetes....

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-45

    authors: Babiker T,Chakera AJ,Shepherd M,Hattersley AT

    更新日期:2014-06-09 00:00:00

  • Drug-related risk of severe hypoglycaemia in observational studies: a systematic review and meta-analysis.

    abstract:BACKGROUND:Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient's quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in pa...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12902-015-0052-z

    authors: Czech M,Rdzanek E,Pawęska J,Adamowicz-Sidor O,Niewada M,Jakubczyk M

    更新日期:2015-10-12 00:00:00

  • Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegeneration.

    abstract:BACKGROUND:Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration. Intra-cerebral Streptozotocin, a nitrosamine-related compound, causes neurodegeneration, whereas periph...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-10-4

    authors: Tong M,Longato L,de la Monte SM

    更新日期:2010-03-19 00:00:00

  • Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study.

    abstract:BACKGROUND:Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0068-4

    authors: Lyhne JM,Laugesen E,Høyem P,Cichosz S,Christiansen JS,Knudsen ST,Hansen KW,Hansen TK,Poulsen PL

    更新日期:2015-12-03 00:00:00

  • Post-partum pituitary insufficiency and livedo reticularis presenting a diagnostic challenge in a resource limited setting in Tanzania: a case report, clinical discussion and brief review of existing literature.

    abstract:BACKGROUND:Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such settings due to high fertility rates, poor obstetric care and scarcity of diagnostic and therapeutic r...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-4

    authors: Sheriff FG,Howlett WP,Kilonzo KG

    更新日期:2012-07-10 00:00:00

  • No increased risk of glucose metabolism disorders in adults with growth hormone deficiency undergoing long-term treatment with biosimilar somatropin (Omnitrope®): data from an observational, longitudinal study.

    abstract:BACKGROUND:To evaluate the impact of treatment with recombinant human growth hormone (rhGH; Omnitrope®) on the risk of diabetes mellitus in adults with growth hormone deficiency (GHD), using data from the ongoing PATRO Adults post-marketing surveillance study. METHODS:PATRO Adults is an ongoing post-marketing surveill...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-019-0464-2

    authors: Beck-Peccoz P,Höybye C,Murray RD,Simsek S,Zabransky M,Zouater H,Stalla G

    更新日期:2019-12-11 00:00:00

  • Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan.

    abstract:BACKGROUND:Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. METHODS:We investigated the association b...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-019-0481-1

    authors: Shirasawa T,Ochiai H,Yoshimoto T,Nagahama S,Watanabe A,Yoshida R,Kokaze A

    更新日期:2020-01-06 00:00:00

  • The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome.

    abstract:BACKGROUND:Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with significantly increased morbidity and mortality, there is still controversy on whether NTIS is cause...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-8-13

    authors: Dietrich JW,Stachon A,Antic B,Klein HH,Hering S

    更新日期:2008-10-13 00:00:00

  • Non-invasive detection of microvascular changes in a paediatric and adolescent population with type 1 diabetes: a pilot cross-sectional study.

    abstract:BACKGROUND:The detection of microvascular damage in type 1 diabetes is difficult and traditional investigations do not detect changes until they are well established. The purpose of this study was to investigate the combined ability of nailfold capillaroscopy, laser Doppler flowmetry, retinal vessel analysis and 24-hr ...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-13-41

    authors: Hosking SP,Bhatia R,Crock PA,Wright I,Squance ML,Reeves G

    更新日期:2013-10-05 00:00:00

  • Medication utilization patterns among type 2 diabetes patients initiating Exenatide BID or insulin glargine: a retrospective database study.

    abstract:BACKGROUND:Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the 'real-world' medication utilization patterns for patients with type 2 diabetes initiating exenatide BID or glargine. The objective of this study was...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-13-20

    authors: Pawaskar M,Bonafede M,Johnson B,Fowler R,Lenhart G,Hoogwerf B

    更新日期:2013-06-22 00:00:00

  • An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study.

    abstract:BACKGROUND:Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from T...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0238-2

    authors: Emral R,Tetiker T,Sahin I,Sari R,Kaya A,Yetkin İ,Cil SU,Tütüncü NB,IO HAT investigator group.

    更新日期:2018-02-13 00:00:00

  • Factors associated with initiation of antihyperglycaemic medication in UK patients with newly diagnosed type 2 diabetes.

    abstract:AIM:To assess the factors associated with antihyperglycaemic medication initiation in UK patients with newly diagnosed type 2 diabetes. METHODS:In a retrospective cohort study, patients with newly diagnosed type 2 diabetes were identified during the index period of 2003-2005. Eligible patients were ≥ 30 years old at t...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-1

    authors: Sinclair AJ,Alexander CM,Davies MJ,Zhao C,Mavros P

    更新日期:2012-03-07 00:00:00

  • Recurrent nocturnal hypoglycaemia as a cause of morning fatigue in treated Addison's disease--favourable response to dietary management: a case report.

    abstract:BACKGROUND:Addison's disease, or primary adrenal insufficiency, is often associated with reduced well-being and fatigue despite use of currently recommended adrenal hormone replacement. Hypoglycaemia is a known manifestation of glucocorticoid deficiency, but is generally considered rare in adults and not relevant to tr...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-015-0058-6

    authors: Petersen KS,Rushworth RL,Clifton PM,Torpy DJ

    更新日期:2015-10-24 00:00:00

  • Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes.

    abstract:BACKGROUND:A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown. This study aimed to investigate the relationship between circulating neutrophils and DKD...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-020-00597-2

    authors: Yu Y,Lin Q,Ye D,Wang Y,He B,Li Y,Huang G,Zhou Z,Xiao Y

    更新日期:2020-10-22 00:00:00

  • Barriers and facilitators to weight management in overweight and obese women living in Australia with PCOS: a qualitative study.

    abstract:BACKGROUND:Lifestyle modification targeting weight management is the first-line treatment for women with Polycystic Ovary Syndrome (PCOS) regardless of presenting symptoms. Women with PCOS are more likely to gain more weight compared with women without PCOS, which may be related to barriers in engaging in lifestyle mod...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-019-0434-8

    authors: Lim S,Smith CA,Costello MF,MacMillan F,Moran L,Ee C

    更新日期:2019-10-23 00:00:00

  • Cost effectiveness and value of information analyses of islet cell transplantation in the management of 'unstable' type 1 diabetes mellitus.

    abstract:BACKGROUND:Islet cell transplantation is a method to stabilize type 1 diabetes patients with hypoglycemia unawareness and unstable blood glucose levels by reducing insulin dependency and protecting against severe hypoglycemia through restoring endogenous insulin secretion. This study analyses the current cost-effective...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-016-0097-7

    authors: Wallner K,Shapiro AM,Senior PA,McCabe C

    更新日期:2016-04-09 00:00:00

  • Accuracy of self-reported height measurements in parents and its effect on mid-parental target height calculation.

    abstract:BACKGROUND:Clinical determination of mid-parental height is an important part of the assessment of a child's growth, however our clinical impression has been that parents cannot be relied upon to accurately report their own heights. Therefore, we conducted this study to assess the accuracy of parental height self-repor...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-7-2

    authors: Braziuniene I,Wilson TA,Lane AH

    更新日期:2007-04-02 00:00:00

  • Insulin resistance as estimated by the homeostatic method at diagnosis of gestational diabetes: estimation of disease severity and therapeutic needs in a population-based study.

    abstract:BACKGROUND:Chronic insulin resistance, exacerbated in the course of pregnancy, is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). We hypothesise that the degree of insulin resistance, assessed at diagnosis of GDM, is a parameter of its pathophysiologic heterogeneity and/or severity. Thus...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-13-21

    authors: Sokup A,Ruszkowska-Ciastek B,Góralczyk K,Walentowicz M,Szymański M,Rość D

    更新日期:2013-07-02 00:00:00

  • A case of masked toxic adenoma in a patient with non-thyroidal illness.

    abstract:BACKGROUND:Non-thyroidal illness (NTI) refers to changes in thyroid hormone levels in critically ill patients in the absence of primary hypothalamic-pituitary-thyroid dysfunction, and these abnormalities usually resolve after clinical recovery. However, NTI can be accompanied by primary thyroid dysfunction. We report h...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-1

    authors: Cho EA,Yoon JH,Kim HK,Kang HC

    更新日期:2014-01-02 00:00:00

  • Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.

    abstract:UNLABELLED: BACKGROUND:The use of chromium supplements is widespread for the prevention and treatment of diabetes mellitus but there are conflicting reports on efficacy, possibly reflecting discrepant effects across different populations. In the present studies, we test the hypothesis that chromium supplementation rai...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-12-31

    authors: Masharani U,Gjerde C,McCoy S,Maddux BA,Hessler D,Goldfine ID,Youngren JF

    更新日期:2012-11-30 00:00:00

  • Current concepts in parathyroid carcinoma: a single Centre experience.

    abstract:BACKGROUND:Parathyroid carcinoma is a rare neoplasm that may present sporadically or in the context of a genetic syndrome. Diagnosis and management are challenging due to the lack of clinical and pathological features that may reliably distinguish malignant from benign disease. METHODS:From January 2013 to December 20...

    journal_title:BMC endocrine disorders

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12902-019-0368-1

    authors: Ferraro V,Sgaramella LI,Di Meo G,Prete FP,Logoluso F,Minerva F,Noviello M,Renzulli G,Gurrado A,Testini M

    更新日期:2019-05-29 00:00:00

  • Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.

    abstract:BACKGROUND:The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS:The study included 1482 sub...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/s12902-018-0232-8

    authors: Song B,Zuo Z,Tan J,Guo J,Teng W,Lu Y,Liu C

    更新日期:2018-01-27 00:00:00

  • Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity.

    abstract:BACKGROUND:Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out ...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-11-7

    authors: Keller P,Gburcik V,Petrovic N,Gallagher IJ,Nedergaard J,Cannon B,Timmons JA

    更新日期:2011-03-22 00:00:00

  • The association between improved quality diabetes indicators, health outcomes and costs: towards constructing a "business case" for quality of diabetes care--a time series study.

    abstract:BACKGROUND:In primary health care systems where member's turnover is relatively low, the question, whether investment in quality of care improvement can make a business case, or is cost effective, has not been fully answered.The objectives of this study were: (1) to investigate the relationship between improvement in s...

    journal_title:BMC endocrine disorders

    pub_type: 杂志文章

    doi:10.1186/1472-6823-14-92

    authors: Wilf-Miron R,Bolotin A,Gordon N,Porath A,Peled R

    更新日期:2014-12-01 00:00:00