Abstract:
BACKGROUND:Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and association with Epstein-Barr virus (EBV). ENKL with massive lung involvement has been infrequently reported, and its prognosis is extremely poor. CASE PRESENTATION:A 20-year-old Japanese man presented with intermittent fever lasting for 2 months. Radiological imaging demonstrated multiple nodules of uneven shape and size in both lungs. Video-assisted thoracic surgical lung biopsy showed abnormal lymphocyte infiltration, which was positive for CD3, CD56, and perforin. In situ hybridization for EBV-encoded RNA was positive. From these findings, he was diagnosed with ENKL with lung involvement. The patient was successfully treated with intensive combinational chemotherapy followed by allogeneic cord blood transplantation. He has been alive with continuous complete remission for 1 year after diagnosis. CONCLUSIONS:Although ENKL involving the lung has been reported to have dismal outcomes, our patient showed long-term survival after intensive chemotherapy and up-front allogeneic hematopoietic transplantation. The present case highlights the importance of early diagnosis as well as allogeneic transplantation.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Yabushita T,Yoshioka S,Furumiya T,Nakamura M,Yamashita D,Imai Y,Ishikawa Tdoi
10.1186/s12890-019-0815-9subject
Has Abstractpub_date
2019-02-21 00:00:00pages
48issue
1issn
1471-2466pii
10.1186/s12890-019-0815-9journal_volume
19pub_type
杂志文章abstract:BACKGROUND:To evaluate the factors affecting the maximum standardized uptake value (SUVmax) of metastatic lymph nodes in different histological types of non-small cell lung cancer (NSCLC) on integrated positron emission tomography and computed tomography (PET-CT). METHODS:This was a retrospective, single-institution r...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0014-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01254-z
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the most common reason for the hospitalization and death of pulmonary patients. The use of antibiotics as adjuvant therapy for AECOPD, however, is still a matter of debate. METHODS:In this study, we searched the PubMed, EmBase, and Coch...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析
doi:10.1186/s12890-017-0541-0
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:The early diagnosis of non-small cell lung cancer is of great significance to the prognosis of patients. However, traditional histopathology and imaging screening have certain limitations. Therefore, new diagnostical methods are urgently needed for the current clinical diagnosis. In this study we evaluated t...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01314-4
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:To investigate the use of do-not-resuscitate (DNR) orders in patients hospitalized with community-acquired pneumonia (CAP) and the association with mortality. METHODS:We assembled a cohort of 1317 adults hospitalized with radiographically confirmed CAP in three Danish hospitals. Patients were grouped into n...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01236-1
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:Although pleural fluid lactate dehydrogenase (LDH) and adenosine deaminase (ADA) levels are often used to distinguish between tuberculous pleural effusion (TPE) and parapneumonic pleural effusion (PPE), this can be challenging as the LDH level may vary from normal to severely increased in PPE and a significa...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0526-z
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stress and worse outcome in PAH. METHODS:Eighteen PAH patients (p) group 1 NYHA class II/III and ten con...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-69
更新日期:2014-04-24 00:00:00
abstract:BACKGROUND:Pneumonia poses a significant burden to the U.S. health-care system. However, there are few data focusing on severe pneumonia, particularly cases of pneumonia associated with specialized care in intensive care units (ICU). METHODS:We used administrative and electronic medical record data from six integrated...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0552-x
更新日期:2017-12-16 00:00:00
abstract:BACKGROUND:Programmed cell death 5 (PDCD5) was first identified as an apoptosis-promoting protein and involved in some autoimmune diseases and inflammatory processes. Our previous study demonstrated greater expression of serum PDCD5 in asthmatic patients than controls. This study aimed to further explore the significan...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0317-y
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructiv...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-8-1
更新日期:2008-01-26 00:00:00
abstract:BACKGROUND:The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures. METHODS:...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2466-13-45
更新日期:2013-07-12 00:00:00
abstract:BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1186/1471-2466-11-18
更新日期:2011-04-18 00:00:00
abstract:BACKGROUND:This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan. METHODS:This multi-stage, cross-sectional survey was conducted from May 2014-August 2015; comprising 1629 adults in 75 randomly selected clusters in Karachi, Paki...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0753-y
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome (ARDS) is still unclear. METHODS:Consecutive patients admitted to ICU with the diagnosis o...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0666-9
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Systemic inflammation plays an important role in the initiation, promotion, and progression of lung carcinogenesis. In patients with non-small cell lung cancer (NSCLC), fibrinogen levels correlate with neoplasia. Here we compared the effects of pulmonary rehabilitation (PR) with chest physical therapy (CPT) ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-14-121
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of phospholipoproteinaceous material in the alveoli. The presentation is nonspecific but typically includes dyspnea; the spectrum of disease includes rapidly progressive hypoxic respiratory failure. Whole lung lavage (W...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0822-x
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lac...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0232-2
更新日期:2016-05-10 00:00:00
abstract:BACKGROUND:Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12890-016-0331-0
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0066-3
更新日期:2015-07-10 00:00:00
abstract:BACKGROUND:Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., CT-guided PTNB (Percutaneous Transthoracic Needle Biopsy), ENB (Electromagnetic Navigation Bronchosc...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0713-6
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:The collection of exhaled breath condensate (EBC) is a suitable and non-invasive method for evaluation of airway inflammation. Several studies indicate that the composition of the condensate and the recovery of biomarkers are affected by physical characteristics of the condensing device and collecting circum...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-9-48
更新日期:2009-11-30 00:00:00
abstract:BACKGROUND:Cardiac Troponin T (cTnT) elevation during exacerbations of chronic obstructive pulmonary disease (COPD) is associated with increased mortality the first year after hospital discharge. The factors associated with cTnT elevation in COPD are not known. METHODS:From our hospital's database, all patients admitt...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-9-35
更新日期:2009-07-19 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to identify the factors associated with carbon dioxide retention. METHODS:This was a retrospective study of...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0691-8
更新日期:2018-07-31 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a form of chronic fibrosing interstitial pneumonia characterized by progressive worsening of dyspnea and lung function, with a poor prognosis. The objective of this study was to determine treatment patterns, resource use and costs of managing Spanish patients with IPF. ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0168-6
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex and incompletely understood, which includes both genetic and environmental factors that alter vascu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0719-0
更新日期:2018-10-05 00:00:00
abstract:BACKGROUND:Relationships between low forced vital capacity (FVC), and morbidity have previously been studied but there are no data available for the Caribbean population. This study assessed the association of low FVC with risk factors, health variables and socioeconomic status in a community-based study of the Trinida...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0823-9
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-41
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:Scleromyxedema is a progressive, systemic connective tissue disorder characterized by fibro-mucous skin lesions and increased serum monoclonal immunoglobulin levels. Pulmonary involvement occurs in a subset of patients, though the overall prevalence of pulmonary lesions in scleromyxedema is unknown. Since pu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-1020-6
更新日期:2020-01-09 00:00:00
abstract:BACKGROUND:The dysfunction of airway epithelial barrier is closely related to the pathogenesis of asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In the current study, we aimed to explore the role of secreted Hsp90α in asthmatic airway epithelial barrier functi...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0938-z
更新日期:2019-11-20 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic reached Europe in early 2020. Convalescent plasma is used without a consistent evidence of efficacy. Our hypothesis is that passive immunization with plasma collected from patients having contracted COVID-19 and developed specific neutralizing antibodies may alleviate symptoms and reduc...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01361-x
更新日期:2020-12-07 00:00:00