The role of secreted Hsp90α in HDM-induced asthmatic airway epithelial barrier dysfunction.

abstract：BACKGROUND:Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains unclear. Current guidelines recommend treating beyond 4 cycles -up to 6-, in patients that respond to an...

journal_title：BMC pulmonary medicine

authors： Sallam M,Wong H,Escriu C

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwide setting in patients with uncontrolled asthma. We defined uncontrolled asthma as a previous hospit...

journal_title：BMC pulmonary medicine

authors： Gullach AJ,Risgaard B,Lynge TH,Jabbari R,Glinge C,Haunsø S,Backer V,Winkel BG,Tfelt-Hansen J

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:The Darlington and Northallerton Asthma Study is an observational cohort study started in 1983. At that time little was published about long term outcome in asthma and the contribution of change in reversible disease or airway remodelling to any excess deterioration in function. The study design included reg...

journal_title：BMC pulmonary medicine

authors： Connolly CK,Prescott RJ

更新日期：2005-01-31 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF). METHODS:Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related meas...

journal_title：BMC pulmonary medicine

authors： Savi D,Di Paolo M,Simmonds NJ,Pascucci C,Quattrucci S,Palange P

更新日期：2018-04-19 00:00:00

abstract：BACKGROUND:During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association...

journal_title：BMC pulmonary medicine

authors： Esteves T,Aparicio G,Garcia-Patos V

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:Although cigarette smoking may have a negative impact on the clinical outcome of pulmonary tuberculosis (PTB), few studies have investigated the impact of smoking-associated lung diseases. Emphysema is a major pathological finding of smoking-related lung damage. We aimed to clarify the effect of emphysema on...

journal_title：BMC pulmonary medicine

authors： Takasaka N,Seki Y,Fujisaki I,Uchiyama S,Matsubayashi S,Sato A,Yamanaka Y,Odashima K,Kazuyori T,Seki A,Takeda H,Ishikawa T,Kuwano K

更新日期：2020-11-07 00:00:00

abstract：BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...

journal_title：BMC pulmonary medicine

authors： Parker JM,Oh CK,LaForce C,Miller SD,Pearlman DS,Le C,Robbie GJ,White WI,White B,Molfino NA,MEDI-528 Clinical Trials Group.

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:IL-4 and IL-13 play a critical yet poorly understood role in orchestrating the recruitment and activation of effector cells of the asthmatic response and driving the pathophysiology of allergic asthma. The house dust mite (HDM) sheep asthma model displays many features of the human condition and is an ideal ...

journal_title：BMC pulmonary medicine

authors： Liravi B,Piedrafita D,Nguyen G,Bischof RJ

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic...

journal_title：BMC pulmonary medicine

authors： Wells JM,Estepar RS,McDonald MN,Bhatt SP,Diaz AA,Bailey WC,Jacobson FL,Dransfield MT,Washko GR,Make BJ,Casaburi R,van Beek EJ,Hoffman EA,Sciurba FC,Crapo JD,Silverman EK,Hersh CP,COPDGene Investigators.

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a distinct form of interstitial pneumonia with unknown origin and poor prognosis. Current pharmacologic treatments are limited and lung transplantation is a viable option for appropriate patients. The aim of this review was to summarize lung transplantation survival in ...

journal_title：BMC pulmonary medicine

authors： Kistler KD,Nalysnyk L,Rotella P,Esser D

更新日期：2014-08-16 00:00:00

abstract：BACKGROUND:The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrome (ARDS) patients. The purpose of this study is to assess the feasibility and safety of awake ECMO i...

journal_title：BMC pulmonary medicine

authors： Xia J,Gu S,Li M,Liu D,Huang X,Yi L,Wu L,Fan G,Zhan Q

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to investigate the association between NLR and the clinical characteristics of COPD patients and to dete...

journal_title：BMC pulmonary medicine

authors： Sakurai K,Chubachi S,Irie H,Tsutsumi A,Kameyama N,Kamatani T,Koh H,Terashima T,Nakamura H,Asano K,Betsuyaku T

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary function in healthy current- and never-smokers with a wide age range. METHODS:HRCT scans were perfor...

journal_title：BMC pulmonary medicine

authors： Telenga ED,Oudkerk M,van Ooijen PM,Vliegenthart R,Ten Hacken NH,Postma DS,van den Berge M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS s...

journal_title：BMC pulmonary medicine

authors： Wilcox O,Hassanein M,Armstrong J,Kassis N

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe asthma during stable disease and exacerbation events. METHODS:We recruited 102 adults and 34 childre...

journal_title：BMC pulmonary medicine

authors： Ghebre MA,Pang PH,Desai D,Hargadon B,Newby C,Woods J,Rapley L,Cohen SE,Herath A,Gaillard EA,May RD,Brightling CE

更新日期：2019-08-08 00:00:00

abstract：BACKGROUND:Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. CASE PRESENTATION:This report included five cases of Chlamydia psittaci pneumonia. Symptom...

journal_title：BMC pulmonary medicine

authors： Gu L,Liu W,Ru M,Lin J,Yu G,Ye J,Zhu ZA,Liu Y,Chen J,Lai G,Wen W

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:Pulsus paradoxus estimated by dynamic change in area under the oximeter plethysmograph waveform (PEP) might provide a measure of acute asthma severity. Our primary objective was to determine how well PEP correlates with forced expiratory volume in 1-second (%FEV1) (criterion validity) and change of %FEV1 (re...

journal_title：BMC pulmonary medicine

authors： Arnold DH,Jenkins CA,Hartert TV

更新日期：2010-03-29 00:00:00

abstract：BACKGROUND:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radio...

journal_title：BMC pulmonary medicine

authors： Nakagawa H,Otoshi R,Isomoto K,Katano T,Baba T,Komatsu S,Hagiwara E,Nakano Y,Kuwahira I,Ogura T

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Skeletal muscle function dysfunction has been reported in patients with cystic fibrosis (CF). Studies so far showed inconclusive data whether reduced exercise capacity is related to intrinsic muscle dysfunction in CF. METHODS:Twenty patients with CF and 23 age-matched controls completed an incremental cardi...

journal_title：BMC pulmonary medicine

authors： Ruf K,Beer M,Köstler H,Weng AM,Neubauer H,Klein A,Platek K,Roth K,Beneke R,Hebestreit H

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:There is emerging evidence regarding the efficacy of exercise training to improve exercise capacity for individuals with non-small cell lung cancer (NSCLC). Cardiopulmonary exercise testing (CPET) is the gold standard measure of exercise capacity; however this laboratory test has limitations for use in resea...

journal_title：BMC pulmonary medicine

authors： Granger CL,Denehy L,Parry SM,Martin J,Dimitriadis T,Sorohan M,Irving L

更新日期：2015-08-12 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficiency (e.g. SCID with T and B cell deficiency) are particularly susceptible to the development of sever...

journal_title：BMC pulmonary medicine

authors： Verjans E,Kanzler S,Ohl K,Rieg AD,Ruske N,Schippers A,Wagner N,Tenbrock K,Uhlig S,Martin C

更新日期：2018-11-22 00:00:00

abstract：BACKGROUND:Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an important role in hyperoxia-induced ALI. METHODS:Hyperoxic ALI was induced in wild-type (WT) and I...

journal_title：BMC pulmonary medicine

authors： Huang Z,Zhang W,Yang J,Sun F,Zhou H

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:The purpose of our study was to assess the frequency of occult foreign body aspiration (FBA) and to evaluate the diagnostic difficulties and therapeutic methods for these patients. METHODS:Between May 2000 and May 2020, 3557 patients with the diagnosis of FBA were treated in our department. Thirty-five pati...

journal_title：BMC pulmonary medicine

authors： Liu B,Ding F,An Y,Li Y,Pan Z,Wang G,Dai J,Li H,Wu C

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Physical training has been shown to improve exercise capabilities in patients with asthma. Most studies focused on children and younger adults. Previously, the maximum program duration was six months. It is not known whether the same results may be obtained with lower intensity programs and sustained for tim...

journal_title：BMC pulmonary medicine

authors： Meyer A,Günther S,Volmer T,Taube K,Baumann HJ

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:It is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COPD and HRQL. This study examined the effects of COPD in early stages of disease on HRQL over ten year...

journal_title：BMC pulmonary medicine

authors： Wacker ME,Hunger M,Karrasch S,Heinrich J,Peters A,Schulz H,Holle R

更新日期：2014-08-09 00:00:00

abstract：BACKGROUND:During the past decades, numerous efforts have been made to decrease the death rate among lung cancer patients. Nonetheless, the improvement in long-term survival has been limited and lung cancer is still a devastating disease. DISCUSSION:With this article we would like to point out that survival of lung ca...

journal_title：BMC pulmonary medicine

authors： Heuvers ME,Hegmans JP,Stricker BH,Aerts JG

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management. Our aim was to compare real life operational characteristics for three EGFR mutation assays - two targeted approaches ...

journal_title：BMC pulmonary medicine

authors： Cernomaz AT,Macovei II,Pavel I,Grigoriu C,Marinca M,Baty F,Peter S,Zonda R,Brutsche M,Grigoriu B

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Physical and psychological symptoms are the hallmark of patients' subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles and to examine the association of symptom profiles with systemic biomarkers of inflammation. METHODS...

journal_title：BMC pulmonary medicine

authors： Nguyen HQ,Herting JR,Pike KC,Gharib SA,Matute-Bello G,Borson S,Kohen R,Adams SG,Fan VS

更新日期：2016-12-03 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to identify the factors associated with carbon dioxide retention. METHODS:This was a retrospective study of...

journal_title：BMC pulmonary medicine

authors： Wei X,Yu N,Ding Q,Ren J,Mi J,Bai L,Li J,Qi M,Guo Y

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's i...

journal_title：BMC pulmonary medicine

authors： Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth H

更新日期：2015-01-12 00:00:00