Abstract:
BACKGROUND:The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF). METHODS:Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related measurements included: oxygen uptake (V'O2), carbon dioxide production (V'CO2), ventilatory profile, work rate (W), inspiratory capacity (IC), end-expiratory lung volume (EELV). PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS:Exercise tolerance was reduced in most of patients and the mean V'O2,peak value was 75.2% of predicted (28.5 ± 4.8 ml/min/kg). Seventy % of patients responded to CPET with dynamic hyperinflation. Higher incidence of dynamic hyperinflation was found in CF males compared to CF females (p = 0.026). Patients who developed dynamic hyperinflation during CPET had higher vigorous PA (p = 0.01) and more total energy expenditure (p = 0.006) than patients who did not. EELVΔ was related to activities requiring vigorous intensity and total energy expenditure (R = 0.46, p = 0.001; R = 0.57, p < 0.001). CONCLUSIONS:In adults with CF and mild to moderate lung impairment, DPA might not be limited by dynamic hyperinflation.
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Savi D,Di Paolo M,Simmonds NJ,Pascucci C,Quattrucci S,Palange Pdoi
10.1186/s12890-018-0623-7subject
Has Abstractpub_date
2018-04-19 00:00:00pages
60issue
1issn
1471-2466pii
10.1186/s12890-018-0623-7journal_volume
18pub_type
杂志文章abstract:BACKGROUND:As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructiv...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-8-1
更新日期:2008-01-26 00:00:00
abstract:BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...
journal_title:BMC pulmonary medicine
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更新日期:2015-07-10 00:00:00
abstract:BACKGROUND:Anemia is prevalent not only in COPD but also in pulmonary hypertension. We postulated that anemia may have certain prognostic value in COPD concomitant with PH due to COPD (COPD-PH). METHODS:We performed a 12-month prospective investigation to follow up COPD patients with or without PH assessed by right he...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0693-6
更新日期:2018-08-23 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12890-018-0759-5
更新日期:2019-01-10 00:00:00
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pub_type: 杂志文章
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更新日期:2017-11-21 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
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更新日期:2016-01-12 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-10 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2017-03-09 00:00:00
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更新日期:2020-05-04 00:00:00
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journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-10-13
更新日期:2010-03-14 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-11 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-11-07 00:00:00
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pub_type: 杂志文章
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更新日期:2009-02-05 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-29 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-02 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2015-04-30 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-11-27 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2006-11-30 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-07-28 00:00:00
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更新日期:2008-02-28 00:00:00
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更新日期:2020-01-09 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-26 00:00:00
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