Abstract:
BACKGROUND:A variety of large randomized controlled trials (RCT's) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-acting anticholinergic glycopyrronium bromide. METHODS:As the generalizability of results from RCT's is questionable we designed a longitudinal, prospective non-interventional study (DACCORD) of two years duration plus two years extension with at least 6000 participants in approximately 500 primary and secondary care practices in Germany (within the new established COPD National Prospective Registry), to assess patient reported outcomes (PRO's), lung function, adherence and drug safety. To circumvent the hurdle of inappropriate COPD diagnosis in a non-interventional trial, patients have to fulfill the inclusion criteria of the COPD disease management program (DMP) of the German statutory health insurances. Patient management should follow the German national COPD guidelines, which are based on Global Initiative for Chronic Obstructive Lung Disease 2007 (GOLD) report. Labels of prescribed drugs should also be taken into account. Patients received treatment as part of their standard care: at the discretion of the investigator patients were included in one of two arms. A: standard care with glycopyrronium containing regimen, and arm B: standard care without glycopyrronium. DISCUSSION:For 2016 we expect important results regarding longitudinal development of PRO's including exacerbations, lung function, adherence and side effects. We also investigate applicability of the new GOLD staging system in usual care. Data on diagnostic and treatment modalities in current German primary and secondary care, as well as pharmaco-economic data will be generated. TRIAL REGISTRATION:1. German Register for non-interventional studies: http://www.vfa.de/de/arzneimittel-forschung/datenbanken-zu-arzneimitteln/nisdb . 2. EMA EnCePP http://www.encepp.eu/ .
journal_name
BMC Pulm Medjournal_title
BMC pulmonary medicineauthors
Kardos P,Vogelmeier C,Buhl R,Criée CP,Worth Hdoi
10.1186/1471-2466-15-2subject
Has Abstractpub_date
2015-01-12 00:00:00pages
2issn
1471-2466pii
1471-2466-15-2journal_volume
15pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND:This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan. METHODS:This multi-stage, cross-sectional survey was conducted from May 2014-August 2015; comprising 1629 adults in 75 randomly selected clusters in Karachi, Paki...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0753-y
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:An understanding of the needs and behaviors of asthma patients is important in developing an asthma-related healthcare policy. The primary goal of the present review was to assess patient perspectives on key issues in asthma and its management, as captured in patient surveys. METHODS:Local, national, and mu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2466-6-S1-S2
更新日期:2006-11-30 00:00:00
abstract:BACKGROUND:Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of CF. METHODS:A cross-sectional study was performed, from 2009 to 2011, at University of Campinas...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-41
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:Mycoplasma pneumoniae is one of the most common pathogens causing community acquired pneumonia in children. Although the rate of macrolide-refractory Mycoplasma pneumoniae (MRMP) has increased, systemic glucocorticoids as a treatment option has not been validated yet. The purpose of this study was to assess ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,meta分析
doi:10.1186/s12890-019-0990-8
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe asthma during stable disease and exacerbation events. METHODS:We recruited 102 adults and 34 childre...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-019-0906-7
更新日期:2019-08-08 00:00:00
abstract:BACKGROUND:It has been recognized that despite previous stability some patients with idiopathic pulmonary fibrosis (IPF) experience acute clinical deteriorations called acute exacerbations of idiopathic pulmonary fibrosis (AEX-IPF). We hypothesized that pulmonary infection can be excluded based on clinical and laborato...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0066-3
更新日期:2015-07-10 00:00:00
abstract:BACKGROUND:During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin. We selected specific elastin fragments generated by NE for antibody generation and ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0048-5
更新日期:2015-05-03 00:00:00
abstract:BACKGROUND:To evaluate the factors affecting the maximum standardized uptake value (SUVmax) of metastatic lymph nodes in different histological types of non-small cell lung cancer (NSCLC) on integrated positron emission tomography and computed tomography (PET-CT). METHODS:This was a retrospective, single-institution r...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0014-2
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers. METHODS:The deaths of the Greek Cement Workers Compensation Scheme were analyzed covering the perio...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-12-30
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Interleukin-9 (IL-9)-targeted therapies may offer a novel approach for treating asthmatics. Two randomized placebo-controlled studies were conducted to assess the safety profile and potential efficacy of multiple subcutaneous doses of MEDI-528, a humanized anti-IL-9 monoclonal antibody, in asthmatics. METHO...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-11-14
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore, it is necessary to evaluate perioperative management using new inhalant drugs in patients with obs...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0570-8
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA). METHODS:We investig...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-10-56
更新日期:2010-11-07 00:00:00
abstract:BACKGROUND:To investigate the use of do-not-resuscitate (DNR) orders in patients hospitalized with community-acquired pneumonia (CAP) and the association with mortality. METHODS:We assembled a cohort of 1317 adults hospitalized with radiographically confirmed CAP in three Danish hospitals. Patients were grouped into n...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01236-1
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructiv...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-8-1
更新日期:2008-01-26 00:00:00
abstract:BACKGROUND:Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood. METHODS:Using a computer-assiste...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0663-z
更新日期:2018-06-05 00:00:00
abstract:BACKGROUND:US mentholated cigarette sales have increased considerably over 50 years. Preference for mentholated cigarettes is markedly higher in Black people. While menthol itself is not genotoxic or carcinogenic, its acute respiratory effects might affect inhalation of cigarette smoke. This possibility seems consisten...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,评审
doi:10.1186/1471-2466-11-18
更新日期:2011-04-18 00:00:00
abstract:BACKGROUND:Air pollution has many negative health effects on the general population, especially children, subjects with underlying chronic disease and the elderly. The aims of this study were to evaluate the effects of traffic-related pollution on the exacerbation of asthma and development of respiratory infections in ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-130
更新日期:2014-08-07 00:00:00
abstract:BACKGROUND:Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protocol, including oral corticosteroids, budesonide/formoterol maintenance and reliever therapy and a mul...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0314-1
更新日期:2016-11-16 00:00:00
abstract:BACKGROUND:Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to identify new and previously known genetic variants in a set of candidate genes for COPD. METHODS:E...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-016-0309-y
更新日期:2016-11-11 00:00:00
abstract:BACKGROUND:The long-term prognosis of chronic cough and its determinants need to be clarified. METHODS:This is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Qu...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-017-0496-1
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features inform patterns of adherence to pulmonary therapies and how these patterns can be used to develop cli...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-020-01202-x
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:Anti-tuberculosis therapy requires at least six-month treatment with continuous administration of combined antibiotics, including isoniazid, rifampicin, pyrazinamide, and ethambutol. The long-term exposure to antibiotics could cause consequent changes in gut microbiota, which may alter the gastrointestinal f...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12890-019-0981-9
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:This study is a cross sectional analysis, aiming to evaluate if atopy is as a risk factor for exercise induced bronchoconstriction (EIB) among Tunisian athletes. METHODS:Atopy was defined by a skin prick test result and EIB was defined as a decrease of at least 15% in forced expiratory volume in one second ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-9-8
更新日期:2009-02-05 00:00:00
abstract:BACKGROUND:The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is especially demanding since not only parameters like height, weight and ethnical background influence th...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-13-49
更新日期:2013-08-05 00:00:00
abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations,...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-018-0641-5
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:Little is known about whether or how supplemental oxygen affects patients with pulmonary fibrosis. METHODS/DESIGN:A mixed-methods study is described. Patients with pulmonary fibrosis, informal caregivers of pulmonary fibrosis patients and practitioners who prescribe supplemental oxygen will be interviewed t...
journal_title:BMC pulmonary medicine
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2466-14-169
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:It is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COPD and HRQL. This study examined the effects of COPD in early stages of disease on HRQL over ten year...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/1471-2466-14-134
更新日期:2014-08-09 00:00:00
abstract:BACKGROUND:Irisin, a recently discovered myokine, is assumed to be secreted by muscle cells in response to exercise and is involved in the regulation of energy metabolism by browning white adipose tissue cells. However, due to the fact that previous studies revealed conflicting results concerning the association betwee...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章
doi:10.1186/s12890-015-0035-x
更新日期:2015-04-22 00:00:00
abstract:BACKGROUND:Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of these treatme...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2466-14-160
更新日期:2014-10-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC pulmonary medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12890-020-1176-0
更新日期:2020-05-20 00:00:00